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Methods: Rat models of chronic renal failure were made by cut 5/6 kindney or fed with feedingstuff which contains adenine(0.75%) for 4 weeks. Experimental treatment was applied by giving Yi Shen Granule and the curative effect of Yi Shen Granule on ongoing pathological changes of CRF was studied. According to the data of CRF rats in weight, water wastage, hemanalysis(RBC、HGB、HCT、MCV、MCH), urinalysis(volume, specific gravity, pH, proteinuria), blood serum analysis(BUN、Cre、ALB、TP), kidney weight coefficient and kidney morphology ( the grade of expansile renal tubule and the diameter of glomerulus ),the pharmacological effect of Yi Shen Granule could be ascertained.

实验选用0.75%腺嘌呤饲喂法致大鼠慢性肾衰模型和5/6肾切除法致大鼠肾衰模型,考察益肾颗粒对慢性肾功能衰竭进行性病变的影响,以造模动物一般状况观察、血液学指标包括红细胞计数、血红蛋白、红细胞压积、平均红细胞体积、平均红细胞血红蛋白(RBC、HGB、HCT、MCV、MCH),尿液指标(尿量、比重SG、pH值、尿蛋白)、血清生化学指标包括尿素氮、肌酐、白蛋白、总蛋白(BUN、Cre、ALB、TP)、脏器解剖和病理观察指标(肾小管扩张分级评分和肾小球径长)做为判定依据。

Objective: The purpose of our studies are gaining a better insight into the effect of genistein on mesangial cell"s phenotype change and ECM expression plus degradation under DN circumstances.We add genistein with different concentrations in high glucose cultured rat mesangial cells;feed DM rats with the single concentration genistein for different days;to explore the expression of SMemb,the mark of mesangial cell"s hypertrophy phenotype change;to examine the synthesis of Fn as well as the change of the balance between MMP-2 and TIMP-l;to comprehend its effect on renal pathological changes of DM rats and some related factors;trying toexplore the possible mechanisms.Through these studies,we will have some information about the experimental value of genistein in DN field.

目的:为了研究金雀异黄素对DN环境下大鼠MC肥大表型转换标志物SMemb和ECM分泌及降解的影响,我们拟在细胞水平以不同浓度的金雀异黄素作用于高糖培养下大鼠MC,在动物水平以同一浓度的金雀异黄素作用于DM大鼠不同时间,观察细胞表型转换标志物SMemb、ECM主要成分Fn、ECM降解酶系统基质金属蛋白酶—2(MMP-2)/基质金属蛋白酶抑制剂—1(TIMP-1)表达的变化,同时观察金雀异黄素对DM大鼠肾脏病理及影响肾脏病进展的糖脂代谢紊乱的影响,并进一步探讨金雀异黄素发挥作用的可能机制;为明确金雀异黄素在DN治疗中的地位及意义提供实验依据。

trioxymethylanthraquinone could reduce the inflammatory response and extenuate the damage to intestinal mucosa in rat sepsis.

大黄素能减轻CLP所致脓毒症大鼠的炎症反应和肠粘膜的损伤。

objective: to explore the efficacy of high dose dexamethasone on skin damage caused by docetaxel extravasation in a rat model.

目的 探讨大剂量地塞米松治疗多烯紫杉醇外渗性皮肤损伤的疗效。

Result ① STAT3 basically distributings at antrum of the film inside small rat uterus gland is epithelial, epithelial with exuviate film cell.

结果①STAT3主要分布于小鼠子宫内膜腔上皮、腺上皮和蜕膜细胞。

We went to see a fashion show yesterday.beauties and the rat-fuck dress made us get a eyeful.

昨天我们去了一场时装表演。美女和标新立异的服装确实让我们大饱眼福。

We can fabricate our Rat Parks, and we must, if we want them built to spec.

我们能人工制造出自己的"老鼠乐园",而且我们也必须--如果我们希望它们是为自己量身定制造的话。

Methods: Experimental rats were injected with KA (10mg/kg, 5mg/ml) subcutaneously to make status epilepticus model. SE latter 10 day, Use subliminal dosages KA to check falling sickness paroxysm sensibility model; SE latter 10 day , Morris water maze was to evaluate cognitive function in the animals. Changing NPY adopt immunocyte chemistry method to check the rat brain inner is expressed.

本研究给Sprague-Dawley大鼠颈部皮下注射惊厥剂量的红藻氨酸(KA,10mg/kg,5mg/ml),诱发癫痫持续状态(status epilepticus,SE), 10天后,用阈下剂量的KA检测癫痫发作敏感性模型;10天后用Morris水迷宫实验检测动物学习记忆功能变化;用免疫组化技术检测动物海马CA1区CA3区NPY表达的变化。

Objective: To explore the applicated methods for 3D visualization model of the microstructure of the rat neural fasciculus.

目的:探讨构建神经纤维束显微结构三维可视化模型的实用方法。

Abstract] Objective: To explore the applicated methods for 3D visualization model of the microstructure of the rat neural fasciculus.

目的:探讨构建神经纤维束显微结构三维可视化模型的实用方法。

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Everyone Here Smells Like A Rat
Even If You Win, You're Still A Rat
Rat Race
Year Of The Rat
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