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Objective: To research the mechanism of TX0201 abstracted from heart-regulating formula in the treatment of rat with Alzheimer′s disease. Method: The rat models of AD were induced by A β1-40 injected into the bilateral amygdale.

中文摘要:目的:观察调心方有效部位TX0201对Aβ1-40双侧杏仁核注射所致的类阿尔茨海默病大鼠模型学习记忆和皮层、海马细胞凋亡相关基因的影响。

There are distinctdifferences in the distribution and metabolism in the rat tissues after ivadministration of the two epimers of GL. After iv administration,α-GL istarget to the liver, and can be efficiently converted to more glycyrrheticacid thanβ-GL, and it nearly has no accumulation in the tissues.The distribution ofβ-GL in rat tissues appears to be wide throughout thebody, and its metabolism is slower than that ofα-GL to accumulating insome tissues.

结果显示α-GL与β-GL在大鼠体内的组织分布存在显著性差异,大鼠尾静脉注射α-GL后在体内呈肝分布特异性,转化成甘草次酸的速率高于β-GL,无组织蓄积;而β-GL在体内分布广泛,代谢较慢,有蓄积的可能。

The genomes of two group neurons were extracted. Integration of rAAV-hBDNF in rat hippocampal neurons was detected by Southern blot using mh- BDNF and Neo probe labeled by digoxin. The results displayed the genome of rAAV-hBDNF had existed in the rat hippocampal neurons in form of episome.

提取实验组和对照组培养海马神经元基因组,用地高辛标记的mhBD-NF探针和Neo探针分别进行Southern杂交,结果表明,rAAV-hBDNF基因组以附加体形式存在于海马神经元,而并非整合形式存在。

Most rat fanciers prefer one sex of rat over the other.

大鼠fanciers最喜欢某一性别的影响比其他。

Results T-2 toxin could cause rat articular chondroncytes degeneration, necrosis, and appeared many blank areas free cells. Weigert/Van Gieson staining showed obvious collagen fasciculi emergence could be seen. Scanning electronic microscope showed the surface of articular cartilage was wave and rough. Collagen fasciculi ruptured and stack up, and presented a typical 揳rticular dryness?phenomenon. ELISA results indicated, at the stage of 3 month, the level of rat serum CTX-II in T-2 toxin group was higher than that in control group, and the difference had a markedly significance.

结果 T-2毒素可致大鼠关节软骨细胞变性、坏死,出现大面积无细胞区,胶原染色可见明显的&胶原显现&;扫描电镜显示,关节面起伏不平,表面粗糙,胶原纤维断裂、剥脱,关节表面布满裂片状凸起,呈典型的关节&干燥&现象;ELISA检测结果表明, T-2毒素组大鼠血清CTX-II水平在3个月时较对照组明显增加,差异具有统计学意义。

In this study, Adult heart clear inbred strain closed colony SD rat is the receiver, wistar rat is the ...

本研究以清洁级近交封闭群SD大鼠为受者,Wistar大鼠为供者,各24只,建立大鼠腹腔异位心脏移植模型。

objective to investigate whether hypoxia preconditioning exist in adipose tissue,and construct the hypoxemic model of adipose tissue.methods after injected different density cocl2 to rat's subcutaneously of groin,use immunohistochemical method detect hif-1α protein,and use rt-pcr detect hif-1α mrna.results after injected different density cocl2,the adipose tissue of rat's groin express different degree of hif-1αprotein and hif-1αmrna.,and reach the peak when the density is 20-40 mg/kg and the time is 3 h.conclusion hypoxia preconditioning exist in adipose tissue,and the effect of preconditioning is most evidence when the density is 20-40 mg/kg and the time is 3 h.

目的 探讨脂肪组织中是否存在缺氧预适应现象,构建cocl2致缺氧的缺氧模型。方法不同浓度的cocl2大鼠腹股沟区皮下层浸润注射,分别用免疫组织化学法和rt-pcr法检测该区脂肪hif-1α蛋白和hif-1α mrna的表达情况。结果用不同浓度的cocl2行化学缺氧后在不同时间点观察有不同程度的hif-1α蛋白和hif-1α mrna表达,其中,在浓度为20~40 mg/kg,时间为3 h时脂肪组织中hif-1α表达达高峰。结论脂肪组织存在缺氧预适应现象;cocl2的浓度选择20~40 mg/kg,时间选择3 h时缺氧预适应效果较佳。

Objective To study the protective effects of imipramine on glutamate-induced neurotoxicity in cultured rat cerebral cortical neurons.Methods Cortical neurons of fetal of rat were cultured in vitro.The protective effects of Imi on glutamate-induced neurotoxicity were obserced.

目的 研究米帕明对谷氨酸损伤培养鼠皮层神经细胞的保护作用方法分离培养15~18 d胎龄的大鼠神经细胞,加入谷氨酸,观察谷氨酸对神经细胞的损伤作用及米帕明的保护作用。

To observe the activity of Kupffer cell in the process of NASH rat model and the sensitivity of liver injury to endotoxin in the NASH rat for determining the function of Kupffer cell in NASH.

观察大鼠NASH形成过程中Kupffer细胞活性的变化,以及NASH大鼠对内毒素敏感性的改变,明确NASH时Kupffer细胞功能的改变。

Objective To investigate stage is the most important and the relationship with kupffer cell,during isoflurane decrease anoxia-reoxygenation injury in isolated rat liver.Methods We established the model of isolated rat liver.

目的 明确异氟醚减少离体鼠肝缺氧-复氧损伤的作用主要发生在哪一阶段,以及与枯否细胞的关系。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

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