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RESULTS:(1) ET-1 could increase total protein production, surface area, ERKs activity and ［Ca2+］i in cultured cardiomyocyte in dose-dependent manner at concentrations ranging from 10-9 to 10-7 mol/L. And this effect could be abolished by BQ123, an antagonist of ETA receptor, partly inhibited by PTX, but not by BQ788, an antagonist of ETB receptor.（2）The activation of ERKs and the increase of ［Ca2+］i induced by ET-1 were obviously inhibited by PD98059, a selective ERKs kinase inhibitor, and nifedipine, a calcium channel blocker, respectively. Both antagonists partially inhibited ET-1-stimulated cardiomyocyte hypertrophic response.(3) Staurosporine, a selective PKC inhibitor, could inhibit ET-1-stimulated cardiomyocyte hypertrophic response and increase of ［Ca2+］i, but not affect the activation of ERKs.

结果： ①ET-1浓度依赖性增加新生大鼠心肌细胞蛋白质含量和心肌细胞表面积、ERKs活性及［Ca2+］i浓度，以上作用可被ETA受体拮抗剂BQ123所完全抑制，被百日咳毒素部分抑制，而ETB受体拮抗剂BQ788则无效；②ERKs激酶特异性抑制剂PD98059可完全抑制ET-1激活ERKs的作用，钙通道拮抗剂硝苯地平可明显抑制ET-1介导的［Ca2+］i浓度增加，但二者皆仅部分抑制ET-1介导的心肌细胞肥大反应；③蛋白激酶C选择性抑制剂staurosporine并不能明显抑制ET-1介导的ERKs激活，但可抑制ET-1介导的的［Ca2+］i浓度增加及心肌细胞肥大反应。

We have three externs here, ranging from a freshman majoring in Chemical Engineering to a senior majoring in Material Science. They were EXCELLENT!!

我们这里有三个外展实训生，包括念化学工程的大一生和材料科学的大四学生。

65 cases of extremities long bone factures were treated with interlocking intramedullary nail from September 2002 to November 2004. 52 cases were followed up by clinical review and radiograph, ranging from 6 months to 23 months (14 months on average).

对2002年9月～2004年11月收治的65例四肢长骨骨折采用非扩髓交锁髓内打治疗。52例得到随访并进行影像学观察和疗效评定，随访时间是6~23个月（平均14个月）。

With prices ranging over a thousand dollars, purchasing a pair of binoculars can be a major family expense.

随着价格超过一千美元，购买了一双望远镜可能是一个重要的家庭开支。

In this paper, we do far-ranging research on blind multiuser detection algorithm.

本文对盲多用户检测算法进行了广泛深入的研究。

The system designed in the thesis has far-ranging application, good expandability and the character of opening.

本文的结尾还对系统将来的发展方向做出了展望。

It is less intensive, but the more 'far-ranging' instructional offering in our program.

它不是特别强化，但在我们的课程中，有更多'排列式的'辅导。

In recent years, with the rapid development of the Internet and its far-ranging applications, the Internet has become the indispensable tools in our daily life.

近年来，随着互联网在全球的迅速发展和各种互联网应用的快速普及，互联网已成为人们日常工作生活中不可或缺的信息承载工具。

You will lead research and development projects, drive entire product areas and develop far-ranging technical and business expertise.

将领导研发项目，主持整个产品领域和发展广泛的技术和业务专长把握产品的各个方面，并且进一步完善与提高广泛的技术与商业专长职位要求

The system has advantages of small volume, low cost, good real-time performance, high reliability, better expansibility, and is far-ranging to be applied.

所设计的系统具有体积小、成本低、实时性好、可靠性高、扩展性好等特点，具有广泛的应用价值。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。