查询词典 racemate

Pharmacological interactions between the enantiomers may happen when a chiral drug w as used as its racemate .

当手性药物以外消旋体供药用时，其对映体间就可能发生药效学和药代动力学的相互作用。

In order to evaluate the difference between enantiomers and the racemate in the research about pharmacology and toxicology, both high optical pure enantiomers of KMBZ-009 were obtained with efficient method of enzymatic-catalyst kinetic resolution.

2为了评价KMBZ-009光学对映异构体在药效、毒性上是否存在显著性差异，成功地进行了KMBZ-009光学异构体酶促动力学拆分。

Omeprazole can be used as an in vivo probe to distinguish subjects between poor and extensive metabolizers of CYP2C19 activity according to the ratios of/-OPZ plasma concentrations after oral administration of the racemate.

本文首次研究了OPZ在中国健康男性受试者体内的立体选择性药代动力学行为，并与文献中的结果进行了比较，旨在深入研究OPZ体内代谢的立体选择性机理。

Separation of enantiomer for the acidic racemate could be improved with a lower pH value of the mobile phase since the dissociation of acidic compound was impressed, but it did not affect significantly the resolution of neutral compounds.

在流动相中使用低pH值，能有效抑制酸性化合物的解离，从而显著增强其手性识别能力；对于中性化合物，流动相中pH对手性分离影响不大。

For drug substances with chiral centers or other configurational requirements, the specifications and tests should assure that material (whether a single enantiomer or isomer, a racemate, or a known ratio of isomers) with the requisite properties for therapeutic activity has been produced.

对有手性中心或其它结构要求的原料药，相关的控制参数和检验应该能够保证，所生产出原料药具有治疗活动所需特征。

The effects of racemate initial concentration, volume ratio of surfactant to organic solvent, pH value in internal or external phase, pH gradient from external to internal phase, ligand metallicion and system temperature on the performances of chiral separation were discussed.

摘 要：研究在含有Cu2+和N-n-十二烷基-L-脯氨酸手性配体的乳状液膜体系中手性萃取分离氧氟沙星对映体的效果，以及外消旋体的初始浓度、表面活性剂与有机溶剂的体积配比、内外水相pH值、从外水相到内水相pH值梯度变化以及配位金属离子与体系温度对液膜手性分离性能的影响。

The effect of addition of absorbent resin on the preparation of-1-phenyl-1,2-ethanediol from racemate by stereoinversion was investigated, with whole cells of Candida parapsilosis as catalyst.

以近平滑假丝酵母全细胞为催化剂，考察了添加吸附树脂对不对称氧化还原外消旋苯基乙二醇制备-苯基乙二醇的影响。

For drug substances with chiral centers or other configurational requirements, the specifications and tests should assure that material (whether a single enantiomer or isomer, a racemate, or a known ratio of isomers) with the requisite properties for therapeutic actiity has been produced.

对有手性中心或其它结构要求的原料药，相关的控制参数和检验应该能够保证，所生产出原料药具有治疗活动所需特征。

Omeprazole racemate was resolved respectively by simulated moving bed chromatography and batch chromatography with the coated cellulose triphenylcarbamate as chiral stationary phase and ethanol containing 0.1% diethylamine as mobile phase.

用纤维素三苯基氨基甲酸酯涂敷型手性固定相和含0.1%二乙胺的乙醇溶液，研究了模拟移动床色谱和间歇色谱对奥美拉唑对映体的拆分。

Methods: According to the mechanism of cough reflex, the c-fibres's role in the respiratory system, and the principle of isosterism. Here, a peripheral antitussive LD was regarded as a lead compound. Amino functional groups, as substituents at the 1-hydroxy group of the racemate of LD, were introduced into the structure of the molecule. These novel compounds were confirmed by 1H-NMR, MS spectrum. Their antitussive activities were studied on mice in sequential method. The EDT50, the stimulating time that caused cough by NH3 on half of mice, were measured. Then could caculated the ratio R between the EDT50 of the treated groups and control group.

根据咳嗽反射的机制及C-纤维在呼吸系统的作用，以外周镇咳药左羟丙哌嗪为先导化合物，依据电子等排原理，在其结构中引入氨基以取代羟丙哌嗪分子中1位的羟基，设计一系列未见报道的化合物（01-15）；并采用了一条适宜的路线进行合成，通过1H-NMR、MS确证结构；采用&序贯法&实验进行新化合物的镇咳活性研究，动物模型采用氨水引咳小鼠，获得引致半数小鼠咳嗽的氨水刺激时间（EDT50）及给药组EDT50与对照组的比值R。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。