查询词典 quinazoline

METHODS: A simple and timesaving SOCl2 refluxed method was adopted to synthesize five quinazoline compounds as EGFR inhibitors.

我们改进了这种化合物的合成方法，用简单省时的SOCl2回流法合成五种喹唑啉类EGFR TK抑制剂。

The design, synthesis, and angiotensin Ⅱ antagonist activities of several quinazolinone and quinazoline phenoxyphenylacetic acids are described.

本文设计、合成了一系列喹唑啉酮和喹唑啉苯氧基苯乙酸类化合物，并检测了它们的血管紧张素Ⅱ受体拮抗活性。

The characteristics of quinazoline epidermal growth factor receptor inhibitors were briefly described in this paper, and the mechanism of receptor-tyrosine kinase inhibitor was also introduced. The synthesis of this kind of new compound was studied, and the synthetic route was redesigned and the method was modified.

本论文简述了受体酪氨酸激酶小分子抑制剂的发展概况，详细介绍了新型喹唑啉类表皮生长因子受体抑制剂，着重研究了该类化合物的合成，设计并打通了合成路线，同时又合成了25个新化合物。

Objective: through various chemical synthesis target compounds 4 -- 6 - the - 7 -(2 - hydroxyl replace c oxygen radicals) quinazoline compounds were synthesized and the structure of the modified, so as to get high epidermal growth factor receptor tyrosine kinase inhibitor.

目的：通过各种化学合成方法完成目标化合物4--6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉的合成并对目标化合物进行结构修饰，以期获得高活性的表皮生长因子受体酪氨酸激酶抑制剂。

The N(1) atom of the quinazoline can form a stable H- bond with Met-769, while the N(3) atom can form a H-bond with a water molecule.

抑制剂喹唑啉环上的N(1)原子能够和Met-769上的 NH形成稳定的氢键，而抑制剂上的N(3)原子则和周围的一个水分子形成氢键。

In the course of the condensation of 2, 4, 6-triamino quinazoline with substituted benaldehyde, the solvent DMF was replaced by absolute ethanol and the dried 3A clathrates was used as the dehydrating agent in order to improve the yield.

在2，4，6-三氨基喹唑啉与取代苯甲醛的缩合过程中，用无水乙醇代替DMF作溶剂，并用干燥过的分子筛吸收反应过程中生成的水，从而简化了后处理的步骤，并提高了产率。

the target compounds synthesized to synthesize a series after 4 - instead of aniline - 6 -(2 - hydroxyl replace c oxygen radicals) quinazoline compounds has laid a good foundation.

目标化合物的顺利合成为以后合成一系列4-取代苯胺-6-(2-羟基取代丙氧基)喹唑啉类化合物奠定了良好的基础。

The goal of the successful synthesis of compounds for the subsequent synthesis of a series of 4 - to replace the aniline -6 -(2 - hydroxy replace C oxy) quinazoline compounds laid a good foundation.

目标化合物的顺利合成为以后合成一系列4-取代苯胺-6-(2-羟基取代丙氧基)喹唑啉类化合物奠定了良好的基础。

3D-QSAR studies for one large set of quinazoline type epidermal growth factor receptor inhibitors were conducted using two types of molecular field analysis techniques: comparative molecular field analysis and comparative molecular similarity indices analysis .

采用了CoMFA和CoMSIA方法，进行了几类4-苯胺喹唑啉类抑制剂的三维定量构效关系的研究。

The X-ray crystal structure of the complex of quinazoline inhibitor to EGFR-TK revealed that the N3 of the inhibitor form a hydrogen bond with Thr830 of EGFR-TK through a water molecule.

因此，分子构型的差别是导致化合物SU5402和A1对EGFR-TK活性差异的主要原因。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。