查询词典 quinazoline

In this thesis, a series of benzamides and thioureas derivatives have been designed and prepared. By reasonable photoreaction conditions, a series of benzophenone and quinazoline compounds have been synthesized and structurally determined by NMR, MS and X-ray crystallography, respectively.

本文设计并合成了一系列苯甲酰胺和硫脲衍生物，通过选择合理的光反应条件，合成了一系列二苯甲酮和喹唑啉类化合物，应用核磁、质谱以及X-射线衍射技术对这些化合物的结构进行表征。

Quinazoline is a class of alkaloids,exist in some plants,such as Saxifragaceae, Folium etc.

这些成分主要存在于常山、大青叶等中药中，具有广泛的生物活性。

Odoquinazolin-4(3H)-one,7-methyl-4(3H)-quinazolinone,7-bromoquinazolin-4(3H)-one were synthesized by using anthranilic acid、2-amino-5-nitrobenzoic acid、2-amino-4-nitrobenzoic acid,6-nitro--4(3H)-quinazoline-one、o-amino-terephthalic acid, 2-amino-4-hydroxy benzoic acid、2-amino-5-bromo-benzoic acid、2-amino-5-iodine acid,1、4-butynediol、L-glutamine、isatin anhydride、formamide as starting materials and utilizing microwave-assisted synthetic approach.

本文利用微波辅助合成的方法，以邻氨基苯甲酸、2-氨基-5-硝基苯甲酸、2-氨基-4-硝基苯甲酸、邻氨基对苯二甲酸、2-氨基-4-羟基苯甲酸、2-氨基-5-溴苯甲酸、2-氨基-5-碘苯甲酸、5-甲基-2-氨基苯甲酸等为原料与甲酰胺反应，以及以1，4-丁炔二醇、L-谷氨酰胺与靛红酸酐反应，共合成了13个喹唑啉酮衍生。。。

Methods: In this paper, a quinazoline purine analogues for the parent nucleus, respectively, and four of its seven introduced to replace the structure of diverse and flexible side-chain amino-benzene, design a series of 4 - to replace the aniline-based -6 - methoxy --7 -(2 - hydroxy replace C oxy) quinazoline compounds.

目的：通过各种化学合成方法完成目标化合物4--6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉的合成并对目标化合物进行结构修饰，以期获得高活性的表皮生长因子受体酪氨酸激酶抑制剂。

However, the research found that the quinazoline ring is not necessary for inhibiting EGFR.

以后的许多化合物都是以PD 0153035为先导化合物进行结构改造和修饰的。

The most potent quinazolinone and quinazoline had pA2 values of 7.0 and 5.9, respectively.

活性最高的喹唑啉酮和喹唑啉的 pA2值分别为7.0和5.9。

In the course of the reduction of 2, 4-diamino-5-methyl-6-nitro quinazoline instead of using 〓 catalytic hydrogenation was used for improving the yield.

改进了原合成路线中的〓〓还原的方法，采用催化氢化的方法（催化剂为5％Pd/C），使反应的产率接近8O％。

Two representative compounds have been determined by X-ray crystallography. The best ratio of reactants, the adequate reaction temperature and solvent have been found by contrast experiments.4. The better photoreaction conditions and irridation times have been confirmed through the different photoreaction results. It is the first time that fifty quinazoline derivatives with biological activity and four photooxidation products with urea functional groups have been obtained by photochemistry method. Two representative compounds, quinazoline derivatives and photooxidation products, have been determined by X-ray crystallography, respectively.

通过实验对比我们找到了较佳的反应物的投料比、反应温度和反应所用的溶剂。4、根据不同条件下的光反应结果，确定了硫脲衍生物的相对较好的光反应条件和光照时间，首次利用光化学手段成功得到50个具有生物活性的喹唑啉衍生物和4个具有脲基官能团的光氧化的产物，测定了两个具有代表性的喹唑啉和光氧化的产物的晶体结构。

These Ir complexes, bearing the chromophore ligand pyridine, isoquinoline and quinazoline respectively, exhibit green-to-red photoluminescence with moderate to high quantum efficiencies in the degassed fluid state and bright emission in solid state.

首先，描述一系列含P^O辅助基的铱金属错合物发光材料之设计概念，这些铱金属错合物藉由pyridine， isoquinoline和quinazoline不同的发光基团调控，磷光放光可以由绿色改变至红色，不论在除氧的溶液态以及固态都有相当不错的量子效率，并且具有效率高、寿命长的优点。

Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。