查询词典 pseudoephedrine

Objective To develop an HPLC method for determination of impurities in ephedrine hydrochloride and pseudoephedrine hydrochloride.

目的 建立盐酸麻黄碱和盐酸伪麻黄碱中杂质的高效液相色谱HPLC测定方法。

Based on the previous literatures, the following major innovation works were carried out in this dissertation:(1) The derivatization reaction conditions of ephedrine and pseudoephedrine with sensitive derivation reagent in aqueous system were studied and two new methods were developed for the assay of them by microemulsion electrokinetic chromatography and micellar electrokinetic chromatography with LIF detection. The sensitivity and analysis times were greatly improved compared with the previous reports;(2) A new method of CZE with indirect LIF detection was developed for the simultaneous determination of six coumarin compounds (esculin, esculetin, isofraxidin, genistein, naringin and sophoricoside) with fluorescein as the probe. The proposed method enlarges the application range of LIF detector, and provides new approach for the analysis of certain compounds difficult to derivatize;(3) Based on the above research, an MEKC with indirect LIF detection method for the simultaneous determination of adenine and guanine in DNA extracts from fungus, maize and soybean was established;(4) A new method for the investigation of the complexes formed between human serum albumin and ampicillin sodium under the simulated physiology conditions using laser light scattering technique was developed.

该论文在综述前人工作的基础上，开展了如下未见文献报道的创新性的研究工作：(1)使用灵敏的衍生试剂对麻黄碱和伪麻黄碱在水体系中的衍生反应条件进行了系统研究，建立了微乳电动色谱-激光诱导荧光检测法和胶束电动色谱—激光诱导荧光检测法测定麻黄碱和伪麻黄碱的灵敏分析新方法，与以前的报道相比，灵敏度和分析时间均有很大改善；(2)使用荧光素钠作为背景荧光试剂，建立了同时分析测定六种黄酮类化合物(秦皮甲素、秦皮乙素、异秦皮定、染料木素、柚皮苷和槐角苷)的毛细管区带电泳—间接激光诱导荧光检测新方法，扩大了激光诱导荧光检测的应用范围，对难衍生化合物的分离分析提供了一种新思路和新途径；(3)以荧光素钠作为背景荧光试剂，建立了一种用于同时测定食品提取DNA中的腺嘌呤和鸟嘌呤含量的胶束电动色谱—间接激光诱导荧光检测新方法；(4)用动态和静态激光散射法研究了模拟生理条件下人血清白蛋白与氨比西林钠盐相互作用所形成的复合物，为药物分子与蛋白质的相互作用、药代动力学等的研究提供了一种新思路。

Determination of pseudoephedrine hydrochloride is important for the quality control of cold medicine which contains it.

测定其含量，是对含有盐酸伪麻黄碱的感冒药进行质量检测的一项重要内容。

Objective To study the pharmacokinetics and relative bioavailability of ibuprofen and pseudoephedrine soft capsules.

目的 研究布洛伪麻软胶囊在健康人体内的药物动力学及相对生物利用度。

Manini, MD, from Harvard Medical School in Boston, Massachusetts, and colleagues."Cardiovascular adverse effects can occur, including hypertension, arrhythmias, prolongation of the QT interval, and angina pectoris. Dangers of over-the-counter sympathomimetic use are illustrated by the recent ban on dietary supplements containing ephedrine alkaloids by the US Food and Drug Administration because of increased risk of sudden death, acute myocardial infarction, and stroke."

Manini医师表示，Pseudoephedrine是ephedrine的镜面异构物，会产生肾上腺素的综合促效作用，一般被用来作为解充血剂；此药的副作用包含高血压、心律不整、心电图QT波间距延长及心绞痛等；最近，美国食品药物检验局规定添加剂不得含ephedrine生物碱，由此可看出仿交感神经作用的药物所潜藏的危险；这些危险包含猝死、急性心肌梗塞及中风等。

Detectability of 0.7mg/L for pseudoephedrine hydrochloride, was achieved at a sample throughput rate of 24 times per hour which is 30% lower than that obtained by HDI-based conventional CE.

在24次/h的采样频率下，盐酸伪麻黄碱的检测限为0.7mg/L，比采用压力进样的毛细管电泳法所得的检测限低30%。

Pseudoephedrine and licoflavone might play synergetic effect in antiasthmatic mechnism by the analysis of HPLC.

通过HPLC分析可知，伪麻黄碱和甘草黄酮等可能在平喘机制中起到协同作用。

The method has been successfully applied to the simultaneous determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension.

该法适用于双酚伪麻干混悬剂中氢溴酸右美沙芬和盐酸伪麻黄碱的质量控制及含量测定，方法准确，操作简便。

Ephedrine and pseudoephedrine in wild Mahuang and cultivated Mahuang are separated and determined by RP HPLC A chromatographic method for the separation and the determination of ephedrine and pseudoephedrine in this Chinese drug was established The scientific basis and methodology basis for quality evaluation of wild Mahuang and cultivated Mahuang are provided .

用反相高效液相色谱法分离并测定了野生麻黄与栽培麻黄中的麻黄碱和伪麻黄碱，为野生和栽培麻黄的质量评价提供了科学依据和方法依据。

Pseudoephedrine hydrochloride was developed on basis of developing pseudoephedrine.

在研究精制伪麻黄碱的基础上，由伪麻黄碱制备盐酸伪麻黄碱。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。