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Neural stem cells exist in numerous regions of the central nevous system and have capacity to differentiate into neurons. Noggin promotes adult neurogenesis of subventricular zone and subgranular zone by blocking endogenous bone morphological protein signaling under physiologic state.

神经干细胞存在于中枢神经系统的广泛区域,且这些细胞具有分化为神经元的潜能。noggin通过拮抗内源性骨形态蛋白(Bone Morphological Protein, BMPs)的作用促进生理状态下成年动物室下区和海马齿状回成体神经元发生。

Heat shock factor binding protein 1(HSBP1) is a nuclear-localized, novel, conserved, low molecular weight (00 residues) transcriptional factor, which may repress the activity of the heat shock factor 1 (HSF1) by binding HSF1 active trimerization domain.

热激因子结合蛋白1(heat shock factor binding protein 1, HSBP1)是一种新发现的高保守、低分子质量、定位于核中的一种转录因子,它可抑制HSF1的转录域活性,并协同HSP70负调控热激反应。

Expanding on our demonstration that acylated peptides derived from the large HBV envelope protein block virus entry in vitro, we show their applicability to prevent HBV or woolly monkey hepatitis B virus infection in vivo, using immunodeficient urokinase-type plasminogen activator mice repopulated with primary human or Tupaia belangeri hepatocytes.

已有的研究《Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans》(2007 Hepatology)表明来源于大蛋白的酰化多肽在体外能阻断病毒的进入。利用人源化肝脏或树鼩肝细胞的小鼠模型进行的新研究进一步证实,大蛋白的酰化多肽在防止HBV或者绒毛猴HBV体内感染中具有可行性。

SPARC (secreted protein, acidic and rich in cysteine) is a multifunctional glycoprotein, which influences many important physiological and pathological processes, such as modulating cellular interaction with the extracellular matrix, abrogating cell focal adhesions, inhibiting cellular proli-feration, and regulating the activity of growth factors.

SPARC (secreted protein, acidic and rich in cysteine)即富含半胱氨酸的酸性蛋白,为一种多功能糖蛋白,在各种生理与病理过程中发挥作用,如调节细胞与细胞外基质(extracellular matrix, ECM)相互作用、溶解黏着斑完成抗黏附反应;抑制细胞增殖及调节生长因子活性等。

A 46-year-old man presented with a gradually growing nodule on the left dorsal foot, which had been present for over 10 years. In the beginning, the lesion was treated as a keloid. Because of poor response to treatment, biopsy was arranged. Sections showed a dermal tumor composed of numerous foamy cells, hyalinized wiry collagen, spindle cells and entrapped collagen. The foamy cells were positive for KP1(CD68) and negative for S-100 protein and HMB-45. The histological and immunohistochemical results were consistent with the diagnosis of lipidized fibrous histiocytoma.

一位46岁男性从十年前开始於左足背上出现一个逐渐长大之结节,一开始被当作蟹足肿给予治疗,因为对治疗的反应不好,故安排了切片检查,病理显示一个由大量泡沫状细胞,坚硬而透明之胶原纤维,梭状细胞,胶原纤维束所构成的真皮肿瘤,免疫组织化学染色显示KP1(CD68)阳性,S-100 protein与HMB45阴性,综合病理与免疫组织化学染色结果,诊断为脂肪性纤维组织细胞瘤。

Kelch-like ECH-associated protein-1 (Keap1) normally sequesters Nrf2 in the cytoplasm in association with the actin cytoskeleton, but upon oxidation of cysteine residues Nrf2 dissociates from Keap1, translocates to the nucleus and binds to ARE sequences leading to transcriptional activation of antioxidant and phase II detoxifying genes.

在正常情况下,Kelch样环氧氯丙烷相关蛋白-1 (Kelch-like ECH-associated protein-1, Keap1)可将Nrf2与肌动蛋白细胞骨架一起收集在细胞质内,但是在半胱氨酸残基发生氧化的情况下,Nrf2和Keap1脱离,进入细胞核并与ARE结合,从而激活多种抗氧化基因和II相解毒基因的转录。

Kelch-like ECH-associated protein-1 (Keap1) normally sequesters Nrf2 in the cytoplasm in association with the actin cytoskeleton, but upon oxidation of cysteine residues Nrf2 dissociates from Keap1, translocates to the nucleus and binds to ARE sequences leading to transcriptional activation of antioxidant and phase Ⅱ detoxifying genes.

在正常情况下,Kelch样环氧氯丙烷相关蛋白-1(Kelch-like ECH-associated protein-1, Keap1)与Nrf2耦联,并与肌动蛋白细胞骨架结合被锚定于胞浆,但是在半胱氨酸残基发生氧化的情况下,Nrf2和Keap1解耦联,进入细胞核并与ARE结合,从而激活多种抗氧化基因和Ⅱ相解毒酶基因的转录。

The result indicated that PBP1 was not expressed in stems, leaves and flowers, but specially expressed in root. 4. The protein in Brassica napus homologous to PBP1 was found through amino acid sequence blast and the interaction with BNP23 was identified by Yeast two hybrids assay.

通过同源比对找到与拟南芥PBP1有较高同源性的油菜的黑芥子酶结合蛋白(Myrosase binding protein 6,MBP6),再次采用酵母双杂交验证它们的相互作用,结果显示MBP6与BNP23之间也存在相互作用; 5。

Objective To explore the relationship between heart-type fatty acid-binding protein levels and the severity of the affected coronary artery in acute coronary syndrome and to analyze the relevant reasons.

目的:探讨心型脂肪酸结合蛋白(heart-type fatty acid-binding protein,H-FABP)与近期发作急性冠脉综合征的患者冠脉病变严重程度的相关性及原因。

Objective To investigate the changes and the significance of the expression of Huntingtin-associated protein 1 (HAP1) in the adrenals of rats with to chronic multiple stress.

目的 探讨慢性复合应激大鼠肾上腺髓质细胞亨廷顿蛋白相关蛋白1(Huntingtin-associated protein 1,HAP-1)表达的变化及其意义。

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It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发,分析对称连杆曲线上鲍尔点的产生条件,提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品,年生产总值3000万美元,产品价廉物美、选料上乘、质量保证,深受国内外客户的青睐

The eˉtiology of hemospermia is complicate,but almost of hemospermia are benign.

血精的原因很,以良性病变为主。