查询词典 prostate

The hypermethylation of 5 CpG in promoter region serves as a mechanism of the inactivation of RASSF1A gene. This mechanism has been widely confirmed in multiple tumorgenesis including prostate carcinoma cell line DU145. Object Our study is to disclose the epigenic mechanism of the carcinogenesis of prostate cancer. Including: 1. We use demethylation agents in combination with chemotherapeutic drugs, to disclose whether demethylation agents can enhance the anticancer effect of chemotherapeutic drugs. 2. to study whether demethylation drugs can affect the methylation level of RASSF1A gene in.

目的 本研究旨在探讨前列腺癌的表遗传学发生发展机制，包括： 1、甲基化抑制剂与多种化疗药物联合应用，探讨二者间的协同作用，增强化疗药物疗效； 2、体外应用甲基化抑制剂对前列腺癌细胞DU145的RASSF1A基因甲基化水平的影响； 3、体外应用甲基化抑制剂对前列腺癌细胞DU145的RASSF1A基因及蛋白表达的影响，以期为进一步深入探索通过改变抑癌基因的甲基化而为前列腺癌发生机制和基因治疗提供有意义的数据和理论依据。

Owing to similarities between mammary and prostate epithelia, we examined IKKalpha inolement in prostate cancer and its progression.

由于乳腺和前列腺上皮之间的近似性，我们调查IKKalpha在前列腺癌和它的进展中的。

Prostate regards male reproduction system as the biggest accessary sexual gland, fluid forms its excretive prostate seminal 1/10 ～ 1/3, have protection, enhance spermatozoon activity to reach lubricant and urethral wait for action.

前列腺作为男性生殖系统最大的附属性腺，其分泌的前列腺液构成精液的1/10～1/3，有保护、增强精子活动及润滑尿道等作用。

The exfoliative cytology of prostatic fluid is valuable in diagnosing the prostate cancer, especially in patients with a high PSA value. It is noninvasive and has cess damage than prostate biopsy.

前列腺脱落细胞学检查诊断前列腺癌是一种有效的方法，尤其是在患者具有较高的PSA值的时候，具有无侵入性，较前列腺活检的损伤更小。

PSMA is a cell surface glycoprotein expressed predominantly in prostate secretory acinar epithelium and prostate cancer cells as well as in several extraprostatic tissues.

PSMA是一种特异表达于前列腺分泌腺泡上皮细胞表面的糖蛋白，鼠源单抗4G5已经被阐明是特异识别PSMA的胞外结构部分。

These cancer cells might histogenetically be related to the transitional or metaplastic epithelium of prostate according to morphological analysis,(2) Mucinous adenocarcinoma, Xanthomatous carcinoma, ductal carcinoma, medullary carcinoma, endometrioid carcinoma, papillary carcinoma and signet-ring cell carcinoma were positive for PSA and 35βH11, these carcinomas might histogenetically be related to prostatic secretory epithelium,(3) Prostatic carcinoid showed positive to PSA, 35βH11, NSE and CgA, corresponded with endocrine cell originator,(4) Small cell carcinoma were negative for PSA, 35βH11, NSE and CgA, whether or not it originates from endocrine cells, storage cells or basal cell of prostate had yet to be proved,(5) 34βE12 marking was negative in cancerous areas of 27 cases, and the basal cells were absent in PPTC.

从形态分析，这两种癌可能同源于移行上皮或化生上皮：（2）粘液腺癌、黄色瘤样癌、导管癌、髓样癌、宫内膜样癌、乳头状癌及印戒细胞癌均显PSA及35βH11阳性，提示这几种癌可能来源于分泌上皮，（3）类癌对PSA、35βH11、NSE及CgA均显阳性，符合内分泌细胞来源，（4）小细胞癌无PSA、NSE及CgA表达，对c-erbB-2及35βH11显阳性，是否来源于前列腺内分泌细胞、储备细胞或基细胞有待证实，（5）27例癌区均无34βE12表达，提示PPTC中基细胞缺失。

Methods: One hundred and sixty patients receiving systematic 13-core biopsy of the prostate were randomized into two groups. Group A (84 cases) received an injection of 5 ml 1% lidocaine into the prostatic neurovascular bundles on each side at the base of the prostate under ultrasound guidance. Group B (76 cases) received 10 ml of intrarectal 2% lidocaine gel five minutes before the procedure.

160例接受经直肠超声引导13点前列腺系统穿刺活检术的患者随机分为A、B两组。A组患者84例，在经直肠超声引导下，于前列腺基底部，左、右两侧精囊与前列腺交接处分别注射1%利多卡因5 ml，B组患者76例，于活检前5 min直肠内灌注2%利多卡因凝胶10 ml。

Subarachnoid block is usually administered for classical transurethralresection of the prostate, so that the patient can be monitoredfor the onset of transurethral resection of the prostate syndromesecondary to irrigant absorption.

经典的经尿道前列腺切除术的麻醉，我们经常是选择蛛网膜下腔阻滞，这样我们可以在监护过程中发现继发于冲洗液吸收引起的经尿道前列腺切术术综合征。

The transurethral partly resection of prostate is a good treatment for the BPH patients at high risk,it has the advantages of shorter operation time ,less bleading early resumption and satisfactory results , the prostatectomy is more trauma , but can totally cut the prostate is the foundamental operation of prostatectomies , it can be chosed if the TURP is failure and it is suitable to be developed in the matrical hospital and the beginners .

经尿道前列腺部分电切术治疗高危前列腺增生的效果理想，具有手术时间短、出血少、创面小、恢复快，并发症少等优点。耻骨上前列腺摘除术创伤较大，但切除腺体彻底，是一切前列腺手术的基础，可作为腔内手术失败后的备选治疗方案，适宜在广大基层医院及初学者间开展。

Resultsthe operating time was from 40 to 200 minutes,the average weight of removed prostate was 25～92（46±22）g, hemorrhage volumn was 75ml during operation. no transurethral resection syndrome and obturator nerve reflex occurred. the 62 patients were followed up for 2～12months,they micturate freely. the symptom of night-urination mend well. the international prostate symptom scoresdecreased from 25.2 to 8.5. the qmax increased from the 5.4ml/s before operation to 16.9ml/s after operation.

结果 手术时间40～200min，切除前列腺组织重量25～92（46±22）g，术中出血量平均75ml，无turp综合征及闭孔神经反射发生。62例患者随访2～12个月，排尿通畅，夜尿症状缓解，ipss评分由术前的平均25.2分下降为术后平均8.5分，qmax由术前8.0ml/s增到18.5ml/s。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。