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Hageman, Ph.D., group director for discovery pharmaceutics for Bristol-Myers Squibb Company in Princeton, New Jersey."There's a growing push to quickly identify unacceptable biopharmaceutical properties and toxicologic effects, using the most advanced technologies available, thus eliminating compounds with poor properties early."

Hageman博士说:&我们面临越来越大的压力去使用如今世界上最先进的技术尽快鉴定出不合适的生物药学特性以及毒性,从而尽早淘汰掉那些具有不良特性的先导化合物。&

Based on analyses of the lithologic associations, logging electric properties and microscopic biological properties, this paper discusses the logging stratigraphic division of the 4th member of the Upper Trias.

川东北地区由于位于四川盆地边缘,受沉积相变化和构造运动的影响,该区特别是其中部嘉一段—上二叠统横向变化大,录井分层困难。

In present paper the Surface electric properties of alumina trihydrate and its effect on adsorption properties of surfactants on ATH / Water interface were examined.

l前言氢氧化铝作为无机阻燃剂在塑料工业中已得到了广泛应用,其表面有机化改性是其应用中最引人注目的重要课题¨q'。

The characteristic of BMS silica mesostructure and the effect of various synthesis factor (including ammonia/silica molar ratio, composition concentration variation, surfactant alkyl chain length, auxiliary organic molecules such as trimethylbenzene, catalyst structure and properties, solvent and cosolvent volume and its polarity, aging and drying conditions and postsynthesis hydrothermal treatment and so on) on the resultant BMS silica structure and properties were assessed using a series of analytical techniques such as XRD, SEM, TEM,〓Si MAS NMR, TG-DTA and N〓 adsorption measurements.

结果显示BMS二氧化硅分子筛是由大量封装胶束的纳米二氧化硅颗粒(约为20-40nm)堆积形成的聚集体,其双介孔分布中较小的介孔起因于颗粒内部表面活性剂模板形成的介孔,我们称之为骨架介孔。它类似于我们在MCM-41中看到的介孔,可通过改变表面活性剂胶束的尺寸而在2.56-3.65nm的范围内进行调节。

In the results of the optical properties, these molecular monomers have different HOMO and LUMO energy gap such that there are dual-emission and energy transfer mechanism in solution fluorescence spectrum. In the study of the electrochemical properties, various of triphenylamine derivaties have different oxygen binding site and they make elecropolymerization happen or not. In the applications of the hole-transport materials, the performance of compound 21 is better than other compounds. The electropolymerized-film may have residual cation molecules so they can increase the concentration of hole-transport. Due to this reason , compound 21 is suitable to become hole-transport materials.

在光学研究方面,由於目标化合物内单体的HOMO及LUMO能阶差异,使得在溶液萤光放射上有双发射及能量转移的情形发生;在电化学研究方面,不同的三苯胺衍生物由於氧基的位置不同,使得取代基在间位的化合物有不错的电聚合效果;而元件的应用上,具有咔唑基团的化合物21由於在形成电聚薄膜后,可能有残余的阳离子态化合物,使得电聚薄膜内的电洞数浓度较高,因此与其他元件相比之下,有较低的启动电压和不错的元件效率。

A series of lanthanide complexes (Ln = Er, Nd, Yb) with infrared emission properties were designed and synthesized by using different anionic ligands [1 -phenyl-3-methyl-4-(4-tertbutylbenzoyl)-5-pyrazolone and l-phenyl-3-methyl-4--5-pyrazolone and 2-naphtoyl trifluoroacetone] and netural ligands (2,2-dipyridine, phenanthroline, triphenylphosphine oxide and water). Three crystal structures of these complexes were obtained and structure studied, and the properties of photoluminescence and fluorescent lifetime were studied in detail.

我们通过选用不同的第一配体[1-苯基-3-甲基-4-(4-异丁酰基)-5-吡唑酮,1-苯基-3-甲基-4-(4-叔丁基苯甲酰基)-5-吡唑酮和2-萘基三氟乙酰丙酮]和第二配体(2,2-联吡啶,邻菲啰啉,三苯基氧膦)合成了16个稀土红外配合物(Ln=Er,Nd,Yb),获得了其中三个配合物的单晶结构,研究了这些稀土红外配合物的光致发光和荧光寿命等性质。

According to the experimental data,using the best square approach way,the linear extent magnetostriction properties equation of Terfenol-D material is made,then the magnetostriction properties equation under a unconstant preloading is educed.

根据实验数据,利用最佳平方逼近的方法,确定了Terfenol-D材料线性范围内的磁致伸缩特性方程,并进而得出了变载荷磁致伸缩特性方程。

In this dissertation,Co-Cr2O3 and Fe-Cr2O3 granular films with superiorproperties have been successfully fabricated by RF co-sputtering technique underroom and 77K substrate temperatures for the first time.The microstructure,electrical transport and magnetic properties as well as their relation to TMR effectare systematically investigated by various techniques such as X-Ray diffraction,transmission electron microscopy,electrical diffraction,X-Rayphotoelectron spectroscopyand VSM,etc.,the change of electrical transportand magnetic properties in these films with their microstructure is also shown.Someinteresting and valuable results have been obtained after the theoretical fitting ofexperimental data with the existed theory.The temperature dependence of TMReffects in these films and the way to get larger TMR effect is also studied.Our mainprincipal results obtained are as follows:(1)Microstructure and Magnetism

在本论文中,我们采用射频共溅射方法,在室温及77K的衬底温度下首次成功地制备了性能优异的Co-Cr2O3及Fe-Cr2O3系列颗粒薄膜,并利用X-Ray衍射、透射电镜、电子衍射、X-Ray光电子谱及宏观电性及磁性测量等手段详细地研究了Co-Cr2O3颗粒膜的微结构、电性、磁性及它们与TMR效应之间的关系,系统地研究了薄膜的电性和磁性随薄膜微结构的变化,通过实验数据点的理论拟合,得出了一些有价值的物理信息,探讨了磁电阻效应的温度依赖性及获得较大TMR效应的途径,主要内容可概括如下

Based on the evaluation of rock mechanics properties of undrilling formation, a fuzzy optimization model for selecting the best similar layers with the same rock mechanics properties was established by applying theory of fuzzy optimization. Firstly the best similar layer located the undrilled area was chosen by the model. Secondly the performance of the bit used in the selected layer was evaluated by economic benefit index.

该方法在待钻地层岩石力学性质评价的基础上,首先应用模糊优选理论建立了地层岩石力学性质相似层位的模糊优选模型,用其进行相似层位的优选,然后应用经济效益指数法对相似层位的钻头性能进行评价,最后给出合理的钻头选型结果。

Analytical formulae are presented for the first time to describe the shift in the resonance wavelength of LPG in response to etching of the fiber cladding or a change in the external refractive index. The accuracy of the formula is confirmed by comparision with numerical simulations and experimental results. We demonstrated that the resonance wavelengths of an etched LPG are more sensitive refractive index than those of an unetched grating. The bending properties of long period fiber grating written in different type fiber are studied experimentally. The transmission peaks and the central wavelength of LPG change with the bending of the fiber. A new peak appears at the shorter wavelength when the fiber is being bent. The changes of the peaks are different for different photosensitive fiber. Those properties have broad application foreground in fiber sensors and tunable filters.

分别从理论和实验上对长周期光栅的折射率特性以及光纤包层半径对长周期光栅特性的影响进行了研究,首次给出了描述光纤包层半径腐蚀和外界折射率改变与长周期光栅共振波长关系的理论表达式,实验与理论和数据模拟的结果很好符合,利用腐蚀光纤包层的方法可以有效地提高LPG的折射率灵敏度;对不同光纤中写入的长周期光栅的弯曲特性进行了实验研究,LPG的透射峰形状及其中心波长随光纤弯曲而发生变化,并且随着弯曲将在短波方向出现新的透射峰,其透射峰的变化规律因所用光敏光纤的不同而不同,这一特性在光纤传感和可调谐滤波器方面有重要的应用前景。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。