查询词典 promoters

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

Genes encoding Drought-Responsive-Element Binding proteins were cloned from Triticum aestivum and Atriplex hortensis. TaDREB1 and AhDREB1 can specifically bind the DRE elements in the promoters and thus activate the transcription of downstream genes in yeast cells as well as transgenic Arabidopsis and transgenic tobacco plants.

克隆了小麦和山菠菜转录因子TaDREB1和AhDREB1基因，它们都编码DRE（Dehydration-Responsive-Element）结合蛋白，在酵母单杂交系统、转基因拟南芥和转基因烟草中都能特异结合DRE元件并激活下游报告基因的表达。

Instead of plasmids the strong bacteriophage T5 promoter has been used to replace native promoters in E.

而非质粒强烈噬菌体T5的启动子已被用来取代本土启动子在大肠杆菌中。

As already noted, the marriage of a contestant to a spectator is also ballyhooed. The promoters are too cynical to believe it.

之前也提到过，一名参赛选手和一个观众之间的婚姻也被大肆宣传，可笑的是这些比赛的发起人认为这样的举动能大受欢迎。

Results: There was a clear bimodal distribution of 80 microsatellite instability-high tumours according to the number of methylated promoters, with no tumours showing 3/5 methylated loci.

结果：根据启动子甲基化数目，80例高度微卫星不稳定的肿瘤出现明显的双峰分布，没有肿瘤是3/5的位点甲基化。

There can be no doubt that the English Reformation is substantially a part of the great Protestant Reformation upheaval of the sixteenth century, and that its doctrine, liturgy, and chief promoters were to a very considerable extent derived from, and influenced by, the Lutheran and Calvinistic movements on the Continent.

因此，可以毫无疑问，这英语改革是大大的一部份伟大的新教改革动荡的16世纪，它的教义，礼仪中，行政推动者都是一个相当大程度上源於，并影响，路德和calvinistic变动对非洲大陆。

According to the promoters of the party, the square will be transformed with a diverse selection of live performances including a traditional Chinese dragon and lion dance.

据该聚会的承办人所说，该广场将会焕然一新，到处是各式各样的现场表演，包括传统的中国舞龙和舞狮表演。

During this period, the commercial capital played a major role in commercial capitalists become the main promoters of colonial expansion.

在这一时期，商业资本起了主要作用，商业资本家成为殖民扩张的主要推动者。

By using nanosized coper catalyst precursors, and preferably nanosized promoters as well, D/T values of greater than 10, and preferably greater than 15, are obtainable with silicon conversions in excess of 80 wt.%.

通过使用纳米级铜催化剂前体，以及优选纳米级促进剂，大于10，和优选大于15的D/T值可在硅转化率超过80wt。％的情况下实现。

By means of polymerase chain reactionand DNA recombinant techniques,the gene encoding mature ouse IL-4 was obtained from plasmid pCD-mIL4 and was inserted into expressionvector pBV220,which contains _RP_L double promoters,synthesized SD sequence and temperaturesensitive CIts857 gene,thus an expression lone eferred as pBV-mIL4 was constructed.

该质粒含有 P_RP_L 串联启动子，合成 SD 序列和温度敏感的CIts857基因，并且去除了完整小鼠 IL—4 cDNA 中3′侧翼非编码区，以原核系统高频使用的强终止密码子TAA 代替了原小鼠 IL-4基因的终止密码子 TAG，经 SDS-PAGE 及凝胶密度扫描分析，表达的重组小鼠 IL-4分子量约为14.2KDa，占总菌体蛋白量的25～30%。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。