查询词典 progression

Objective To investigate the expression of S100A4 and MMP-9 and their roles in the progression of oral squamous cell carcinoma.

目的 探讨S100A4和MMP-9在口腔鳞癌中的表达与临床病理学特征的关系。

Subchondral bone is hypothesised to be important in the development and progression of osteoarthritis; however, little is known about the determinants of subchondral bone.

软骨下骨被认为与骨性关节炎的发生发展密切相关，但是其相关影响因素尚未明确。

Basic on the special mechanism of action of Apo2L/TRAIL, the broad-spectrum antitumor activity and superordinary safety of recombinant human soluble Apo2L/TRAIL in preclinical researches, and the progression of the antitumor study on endogenous antiangiogenic factors, two studies were involved in this paper, including phase I clinical trial of rh-Apo2L and the study on expression of the fusion proteins of human Apo2L and endogenous antiangiogenic factors.

基于Apo2L／TRAIL独特的作用机制、重组人可溶性Apo2L／TRAIL临床前体现出的广谱的抗肿瘤作用和良好的安全性、以及内源性血管生成抑制因子抗肿瘤研究进展，本课题开展了下述两方面的研究：①国产重组人凋亡素2配体(rh-Apo2L)的Ⅰ期临床研究；②人Apo2L／TRAIL与人血管生成抑制因子融合表达的基础研究。

OBJECTIVE :To synthetically analyze progression in the study on mechanism of induction of neural stem cell differentiation.

目的：综合分析神经干细胞分化诱导机制的研究现状。

Meta-analyses showed that the response rate of TP (topotecan + cisplatin) regimen had no significant difference compared with EP regimen (etoposide + cisplatin) with OR 0.83 and 95%CI 0.63 to 1.09, but myelo-suppression such as leucopenia and thrombopenia was more severe with TP regimen; the response rate of monotherapy with topotecan was similar with that of CE (carboplatin + etoposide) regimen with OR 0.59 and 95%CI 0.22 to 1.60; the response rate of TEP (topotecan + etoposide + cisplatin) regimen was comparable with that of EP regimen with OR 1.37 and 95%CI 0.82 to –2.28, but myelosuppression and anemia were more severe with TEP regimen; the response rate with OR 0.97 and 95％CI 0.60 to –1.57, median time to progression with WMD –2.32 and 95％CI –5.72 to 1.09 and median survival time with WMD –1.65 and 95％CI –7.13 to 3.83 of IV topotecan were similar to those of oral topotecan, while neutropenia was more severe with IV topotecan.

Meta分析结果表明，TP 方案与EP方案的反应率相似 [OR 0.83， 95%CI (0.63，1.09)]，但具有相对高的致血小板下降的骨髓毒性；单药拓朴替康与CE方案的反应率相似 [OR 0.59， 95%CI (0.22，1.60)]；TEP方案（拓扑替康＋足叶乙甙＋顺铂）与EP方案的反应率相似 [OR 1.37， 95%CI (0.82，2.28)]，TEP方案致化疗后重度白细胞下降、重度血小板下降、重度血红蛋白下降均高于EP方案；口服拓扑替康与静脉滴注拓扑替康的化疗后反应率 [OR 0.97， 95％CI (0.60，1.57)]、中位疾病进展期 [WMD –2.32， 95％CI (–5.72， 1.09)]、中位生存期 [WMD –1.65， 95％CI (–7.13，3.83)] 相似，口服拓扑替康化疗后重度中性粒细胞下降明显低于静脉滴注拓扑替康。

Meta-analysis based on included studies showed that response rate of TP regimen has no statistic significance compared with EP regimen[OR0.83,95%CI(0.63-1.090)],but myelo-suppression such as leucopenia and thrombopenia is more severe; response rate of single topotecan has no statistic significance compared with CE regimen[OR0.59,95%CI(0.22-1.60)]; response rate of TEP regimen has no statistic significance compared with EP regimen [OR1.37, 95%CI(0.82-2.28)], but myelo-suppression such as leucopenia, thrombopenia and anemia is more severe; response rate of IV topotecan has no statistic significance compared with Oral topotecan[OR0.97, 95%CI(0.60-1.57)],so as median time to progression[WMD-2.32, 95%CI(-5.72,1.09)] and median survival time[WMD-1.65, 95%CI(-7.13,3.83)],while neutropenia is more sever in IV topotecan than Oral topotecan.

分析表明，TP方案与EP方案的反应率相似[OR0.83，95％CI(0.63-1.090)]，但具有相对高的致白细胞和血小板下降的骨髓毒性；单药拓扑替康与CE方案的反应率相似[OR0.59，95％CI(0.22-1.60)]；TEP方案与EP方案的反应率相似[OR1.37，95％CI(0.82-2.28)]，TEP方案致化疗后重度白细胞下降、重度血小板下降、重度血红蛋白下降均高于EP方案；口服拓扑替康与静脉滴注拓扑替康的化疗后反应率[OR0.97，95％CI(0.60-1.57)]、中位疾病进展期[WMD-2.32，95％CI(-5.72，1.09)]、中位生存期[WMD-1.65，95％CI(-7.13，3.83)]相似，口服拓扑替康化疗后重度中性粒细胞下降明显低于静脉滴注拓扑替康。

Background Selectie cyclooxygenase inhibitors may retard the progression of cancer, but they hae enhanced thrombotic potential.

背景选择性环氧化酶抑制剂能够延缓癌症的进展，但是它们也有更强的致血栓作用。

The results show that, after adjusting for potential confounders, very large BMLs at baseline are associated with a significantly higher risk of progression of total tibiofemoral cartilage defects as compared to no BML at baseline.

在基线时无疼痛的健康妇女中，大量的BML与整个胫股关节中软骨缺损的进展和侧面胫骨软骨更迅速的损失具有相关性。

Therefore, transcriptional regulation of the APP gene may be of critical importance in the initiation and/or progression of Alzheimer's disease.

因此，APP基因的转录调控可能在AD的发生、发展中至关重要。

By tens of years development,the study on Cutting Slope Stability of Motorway has experienced such a progression: From statistic to dynamic, confirming to unconfirming,double dimensions to three-dimension and from isotropy to anisotropy.

针对现有众说纷纭的边坡稳定性分析理论与方法，本文总结了其研究现状及发展历程，并进行了系统地分类和总结，为高速公路路堑边坡的稳定性评价提供指导和依据； 2。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。