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ConclusionThe expression of α-B crystallin in IDC is significantly higher than that in DCIS and is positively related to lymph node metastasis. There are also higher levels of expression in the HER2+ and the triple-negative groups. This suggests that α-B crystallin is involved in the process of progression and metastasis of breast cancer.

结论α-B crystallin在乳腺浸润性导管癌中的表达明显高于导管原位癌，与淋巴结转移呈正相关，且在生物学行为更为恶性的HER2+组和三阴性组具有更高的表达水平，提示α-B crystallin蛋白可能参与了乳腺癌的浸润与转移过程。

In anticipation of achieving the above objectives, marine-derived actinomycetes, H2003 and Aspergillus terreus Thom have been screened by using this model, the EtOAC extracts of strain H2003 and Aspergillus terreus Thom showed bioactivities of inhibiting the cell cycle progression and cytoclasis of t...

并采用活性追踪分离方法对一株放线菌和一株真菌的代谢产物活性成分进行了初步研究采用减压硅胶柱层析、凝胶柱层析(Sephadex LH-20)、反相硅胶柱层析和反相制备高效液相等分离手段，从具有细胞坏死活性的放线菌H2003分离得到22个单体化合物。

Cytogenetical evolution was always associated with disease progression in subacute myeloid leukemia patients.

亚急性髓性白血病在病程中出现核型演进时，均伴有病情进展，多为进展到显著的白血病阶段。

Postoperative manifest refraction was also improved by surgery, showing minimal but significant regression after 1 year. Final BCVA loss was seen in 10 eyes of 7 patients; in 7 cases, there were obvious reasons such as the progression of cataracts in 3 eyes, epithelial disintegrity due to dry eye in 2 eyes, irregular astigmatism due to flap striae in 1 eye, and age-related macular dystrophy in 1 eye.

手术后的显然验光视力也有提高，在1年后表现为极微量却显著的回退。7例患者的10只眼发生了最佳矫正视力的下降，但均有明显原因，如3只眼发生了白内障，2只眼角膜上皮不完整，1只眼由于角膜瓣皱褶导致不规则散光，1只眼为年龄相关性黄斑萎缩。

The abnormal expression of ECad may play an important role in primary prostate cancer progression, ECad examination is useful for the judgement of tumor development and prognosis.

ECad蛋白异常表达在前列腺癌的恶性进展中起重要作用，检测ECad蛋白的表达有利于判断病期及预后。

Combined use of zinc and antioxidants slowed the progression of adanced age-related macular degeneration in high-risk persons."No consistent aderse effects of multiitamin and mineral supplements were eident," the report states.

联合应用于高危人群中的锌和抗氧化剂延缓了晚期年龄相关性黄斑变性的进展，报告人员声称，&多元维生素和微量元素制剂无显著一致的不良作用。&

A clear cause-and-effect relationship between excessive myocardial MMP-1 activity, increased mysial collagen degradation, and progression to systolic HF has been shown experimentally through the use of transgenic models and the use of pharmacological MMP activators.53,54 In addition, experimental evidence has been provided showing that following chronic neurohormonal activation, increased synthesis and release of MMPs into the local extracellular matrix of the cardiomyocyte occurs,55 which in turn could contribute to endomysial and perimysial collagen degradation and disruption.

一个明显的因果过多的心肌MMP-1关系活动， mysial增加胶原蛋白的降解和进展收缩性心力衰竭已被证明试验，通过使用转基因模型和使用的MMP药理作用此外，activators.53，54实验证据下面被提供显示慢性神经激活时，增加的MMPs合成和释放到当地的细胞外基质的心肌细胞发生，55反过来有助于人肌内膜和 perimysial胶原退化和破坏。

Epidemiological studies indicate that obesity plays an important role in the pathogenesis and progression of OA.

流行病学研究显示肥胖在OA的发生发展中起着很重要的作用。

In other words, researchers have to prove that the disruption of this function, either genetically through mutation, or epigenetically through DNA methylation or chromatin modification, causes the initiation or progression of cancer.

换句话说，研究人员必须证明这些功能的中断，或者是通过遗传上的突变，或者是通过表观上的DNA甲基化或染色质修饰，导致癌症的发生以及进一步恶化。

Owing to similarities between mammary and prostate epithelia, we examined IKKalpha inolement in prostate cancer and its progression.

由于乳腺和前列腺上皮之间的近似性，我们调查IKKalpha在前列腺癌和它的进展中的。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。