查询词典 proenzymes

MMPs are secreted as proenzymes, activated ex-tracellularly by limited proteolysis, and are inhibited by TIMPs.

MMPs以酶原的形式被分泌，在细胞外经一定的蛋白水解过程活化，又可以被TIPMs所抑制。

Some extracellular proenzymes may be activated by secreted lysosomal proteinases.

有些细胞外酶原能被分泌的溶酶体蛋白酶所激活。

MMPs are usually secreted as latent, inactive proenzymes, which need to be activated (Fig 1 ), and/or are bound to their native inhibitors, the tissue inhibitors of metalloproteinases.8 Activation may involve proteolysis and/or oxidation of the latent enzyme.8 Proteolytic activation of the proenzymes cleaves the propeptide sequence, which masks the active site of the latent enzyme.

金属蛋白酶常以无活性的酶原方式分泌，而后者要么需要被激活要么与附近的或组织中金属蛋白酶抑制物结合。激活作用包括了具有潜在酶的蛋白水解作用或氧化作用。酶原的蛋白水解激活作用能将掩盖活性部位的潜在酶的前肽序列破坏。

The 94-kDa GLase activity was Ca++ dependent, showed maximal activity in the pH 6-8, their activity was inhibited in the presence of 1,10-phenanthroline, and their proenzymes were cleaved and activated after incubation with organomercurial compounds and trypsin.

72kDa蛋白脢，出现於所有检体，包括未被感染的老鼠，94kDa蛋白脢只出现於广东住血线虫感染老鼠脑部。94kDa蛋白脢活性是一种钙离子依赖性，在pH值6-8时具最大活性，在 1，10-phenanthroline存在下，其活性受到抑制，此蛋白酵素元会被有机汞类及胰蛋白脢切断并活化。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。