查询词典 prickle cell

To further investigate their roles in cell proliferation apoptosis and differentiation, three human leukemia cell lines (K562, U937 and HL60) exposed to various concentration of hexamethylene bisacetamide, a potent inducer of differentiation of transformed cells both in vivo and in vitro, were used as an in vitro model for the study of cell proliferation, differentiation and apoptosis.

为了进一步研究cyclin A和p21在白血病细胞增殖，分化，凋亡中的作用，我们用在体内，外均有抗肿瘤作用的药物六亚甲基二乙酰胺在体外抑制白血病细胞株K562，U937和HL60增殖，诱导其分化，成功地建立了与药物干预浓度呈剂量-效应关系的，具有不同增殖，分化，凋亡状况的实验细胞模型。

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

Increase the bone marrow cell component while reduce the fat component, abnormal the caryon and cytomembrane structure of bone marrow cell and stromal cell, enrich the ribose body, mitochondrion and rough surfaced endoplasmic reticulum in cytoplasm of several organs and tissues, embody abvious improvement of heart muscle, liver, immnune organs, incretory organs and sexual gland.

增加免疫介导型再障小鼠的骨髓细胞成分，减少脂肪成分。使骨髓细胞和基质细胞的细胞核和细胞膜结构趋于正常，使多种脏器组织的细胞浆内核糖体丰富，线粒体及粗面内质网发达。对心、肝、免疫器官、内分泌器官及性腺等亦有明显的改善作用。

Results Established prostate cancer cell lines are eventually infectible by adenoviral vector. The ratio of vector/cell at which infection occurs depends on the specific cell line.

结果腺病毒载体可以转染所有已建立的前列腺癌细胞株，但是每种细胞株转染所要求的载体浓度以及暴露时间不同。

ResultsIn group C and D hyperplasia of epithelium cell and infiltrations of inflammative cell in day 14 that were severe than that of day 7,ciliate cell was piece loss,the glands were hyperplasia（≥40% of group C,≤20% of group D）in windpipe,and pulmonary alveolus were congestion and dropsy.In group C the epidermis were pucked and connective tissue was hyperplasia in the skin,the quantity of hair ball and the sweat glands of group C and D in the food were significantly reduced than that of group A.

结果第14天时，C组、D组气管上皮鳞状化生，C组气管纤毛多呈片状缺损，而D组多呈灶状缺损；两组气管黏膜炎性细胞浸润均较第7天为重，伴气管浆液腺上皮黏液腺化生（D组≥40%、C组≤20%）、肺泡淤血、水肿。C组皮肤表皮呈不规则皱缩、毛球数明显减少；C组、D组足垫部皮肤表皮增厚、汗腺减少伴结缔组织增生。

Spontaneous germ cell death is very important for the removal of germ cells and control of the quantity and quality of sperm. But excessive germ cell death will lead to diminish spermatogenic function and decrease the quality and quantity of sperm. Excessive germ cell death triggered by various regulatory stimuli, including deprivation of gonadotropins and intratesticular testosterone or by estradiol treatment in rats via apoptosis.

生精细胞凋亡是哺乳动物精子发生过程中的一个显著特点，其生理性凋亡对于去除受损的生精细胞，控制细胞数量和保证精子的质量具有重要意义，但生精细胞的过度凋亡可引起生精功能低下，使精子的数量和质量降低。

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

Results In the 260 slices of liver biopsy, there were 20 ones of acute viral hepatitis, 78 ones of chronic hepatitis, 79 ones of hepatocirrhosis, 28 ones of primary liver cell cancer, 27 ones of liver karyon heterogeneity, 20 ones of liver metastatic adenocarcinoma, 12 ones of fatty liver, five ones of alcohol liver, three ones of liver cyst, two ones of congenital bile duct atresia, six ones of illegible structure, 20 ones without liver cell or with few scattered liver cell.

结果 260例肝穿活检组织病例中，急性肝炎20例；慢性肝炎78例；肝硬化39例；原发性肝细胞癌28例；肝细胞核异质27例；肝转移性腺癌20例；脂肪肝12例；乙醇肝5例；肝囊肿3例；先天性胆管闭锁2例；穿刺组织结构模糊6例；未穿到或仅穿到少量肝细胞20例。

Morphological observation of U937 cells by light microscope, electron microscope, image analysis, including maturity of caryoplasm, karyoplasmic ratio, cell diameter, cell volume, cell organs and abnormal materials formation.

观察经Mat诱导后U937细胞形态学改变(包括核浆成熟情况、核浆比例、细胞直径、细胞体积、细胞器及特殊物质形成等)。

The proliferation of SGC-7901 cell line was markedly inhibited by shRNA-GC-CⅢ（ P .05）. There was changes in cell morphology, such as cell volume reduction, karyopyknosis and chromatin conglomeration. FCM showed that GC-C inhibition caused the appearance of sub-G 0 /G 1 peak which increased from 5.47%（48h after transfection） to 5.63%（72h after transfection）.

转染GC-C shRNA真核表达载体后SGC-7901细胞的增殖能力受到抑制（ P 。05）；细胞形态发生改变，细胞体积缩小，核固缩，染色质浓缩聚集于核膜；流式细胞术检测显示G 1 峰前出现亚二倍体峰，转染48、72h后凋亡率分别为5.47%和5.63%（ P nbsp； 0.05）。

The shaping method of noncircular part and the tool holder's radial motion characters in noncircular turning process are discussed in detail in the thesis.

论文详细研究了非圆零件的成型方法和加工过程中刀架的径向运动规律。

I have not really liked him,I do not like his this kind of disposition.

我没有真的喜欢他，我不喜欢他的这种性格。