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The invention is characterized in that phthalide of general formula, wherein n and X have the meaning cited in the description, is reacted with nitrogen heterocycles of general formula: H-Z, wherein Z has the meaning cited in the description, or with nitrogen heterocycle metal salts of general formula in the presence of an aprotic polar diluent and optionally in the presence of a basic auxiliary reaction agent.

本发明涉及制备通式的2－杂环基甲基苯甲酸衍生物的新的方法，其中n、X和Z具有说明书中给出的意义，该方法提供高收率和高纯度，其特征是，通式的2－苯并呋喃酮，其中n和x具有说明书中给出的含义，与通式的氮杂环：H－Z，其中Z具有说明书中给出的意义，或与通式的氮杂环的金属盐在质子惰性极性稀释剂中并任选在碱性反应助剂存在下反应。

RESULTS: On the basis of either flow-cytometric or molecular analysis, 44 of 45 patients with CLL (98%; 95% confidence interval , 88 to 100) had a prediagnostic B-cell clone; in 41 patients (91%; 95% CI, 79 to 98), the presence of the B-cell clone was confirmed by both methods. The presence of immunoglobulin heavy-chain variable genes was determined in 35 of 45 prediagnostic clones (78%).

结果：在流式细胞或分子分析的基础上， 45名白血病患者有44例（98 ％； 95 ％可信区间，88～100 ）具有诊断前B细胞克隆；在41例（ 91％； 95 ％可信区间， 79～98 ），B细胞克隆的存在得到了这两种方法的证实。45个诊断前克隆中有35个(78%)具有免疫球蛋白重链可变基因。

On the basis of the model, the presence or absence of resumptive pronouns in constructions with a left dislocated argument is explained, and the grammaticality or ungrammaticality arising from the presence or absence of pronouns now finds a rigorous proof.

我们把汉语中的某些介词，如&把&、&被&和&给&处理为标示名词组修饰的节点在语义树中位置的标记，既解释了这些介词引入的名词组所受的句法位置上的限制，又佐证了关于动词词项行为假设的合理性。

Diagnosis/testing. A diagnosis of ocular albinism is probable in the presence of congenital nystagmus, iris translucency, and significant hypopigmentation of the ocular fundus periphery in males with normal skin pigmentation and foveal hypoplasia, reduced visual acuity, and aberrant optic pathway projection, as demonstrated by crossed asymmetry of the cortical responses on visual evoked potential. X-linked inheritance is documented by either a family history consistent with X-linked inheritance or the presence of typical carrier signs (irregular retinal pigmentation and partial iris transillumination) in an obligate carrier female.

诊断/检测。对于皮肤色素沉着正常、中央凹发育不全、视敏度降低以及视径投射异常（VEP，表现为视觉诱发电位中皮层反应的交叉不对称）的男性患者，当存在先天眼球震颤、虹膜半透明以及显著的眼基底层边缘色素减退的症状时，可被疑似诊断为眼白化病。X连锁性遗传则以存在与X连锁遗传一致的家族病史，或在一个应当为携带者的女性中存在典型的携带者迹象（视网膜色素沉着不规则以及部分虹膜透射）而被确认。

Methods The present study included twelve undialyzed ESRD patients with anemia.The sera from the uremic patients were added to CFU-E and BFU-E culture in the concentrations ranging from 1.25% to 5%.In vitro CFU-E and BFU-E growth in the presence of sera from ESRD patients was compared with in the presence normal human subjects with the use of normal mice bone marrows.

选择12例尿毒症肾性贫血未透析患者为试验组，另选正常健康体检者12例为正常对照组，将实验组、正常对照组血清分别稀释成不同终浓度，采用甲基纤维素细胞培养的方法对小鼠骨髓细胞进行培养，对比不同浓度血清组红系集落形成单位、红系爆式形成单位的集落数。

objective to investigate the existence of the erythropoiesis inhibitors.methods the present study included twelve undialyzed esrd patients with anemia.the sera from the uremic patients were added to cfu-e and bfu-e culture in the concentrations ranging from 1.25% to 5%.in vitro cfu-e and bfu-e growth in the presence of sera from esrd patients was compared with in the presence normal human subjects with the use of normal mice bone marrows.results the effects of the sera from uremic patients on cfu-e and bfu-e colony growth in concentrations ranging from 1.25% to 5% were investigated to be dose-dependent.the effect increased with the concentrations increasing of the sera（p＜0.05）.there were not significant inhibitory effect on the cfu-e and bfu-e growth of mice bone marrow in vitro from sera of the normal subjects.conclusion the erythropoiesis inhibitors exist in uremic sera which has a dose-dependent inhibitive effects on the growth cfu-e and bfu-e of normal mice bone marrow cells.

选择12例尿毒症肾性贫血未透析患者为试验组，另选正常健康体检者12例为正常对照组，将实验组、正常对照组血清分别稀释成不同终浓度，采用甲基纤维素细胞培养的方法对小鼠骨髓细胞进行培养，对比不同浓度血清组红系集落形成单位、红系爆式形成单位的集落数。结果在实验组中，与血清浓度为0的浓度组相比，与各浓度组血清共同培养的小鼠骨髓cfu-e和bfu-e的集落数均明显减少，且随血清浓度的增加，小鼠骨髓cfu-e和bfu-e的集落数逐渐减少，各浓度组间差异有显著性（p＜0.05）。结论尿毒症患者血清抑制小鼠骨髓红系祖细胞集落形成，随患者血清浓度的增加，抑制作用增强，具有剂量依赖性。

It seems, in fact, as though there existed in certain men a veritable bestial instinct, though pure and upright, like all instincts, which creates antipathies and sympathies, which fatally separates one nature from another nature, which does not hesitate, which feels no disquiet, which does not hold its peace, and which never belies itself, clear in its obscurity, infallible, imperious, intractable, stubborn to all counsels of the intelligence and to all the dissolvents of reason, and which, in whatever manner destinies are arranged, secretly warns the man-dog of the presence of the man-cat, and the man-fox of the presence of the man-lion.

在某些人心里，好象确有一种和其他本能同样纯洁坚贞的真正的兽性本能，具有这种本能的人会制造同情和恶感，会离间人与人的关系，使他们永难复合；他不迟疑，不慌乱，有言必发，永不认过；他卖弄糊涂的聪明'他坚定、果敢，他对智慧的一切箴言和理智的一切批判无不顽强抗拒，并且无论命运怎样安排，他的那种兽性本能发作时，总要向狗密告猫的来到，向狐狸密告狮子的来到。

A one-step method for the synthesis of aromatic indolizine derivatives byintramolecular 1,5-dipolar cyclization reaction of 2-(2-arylethenyl)pyridinium N-ylidesin the presence of an oxidant has been studied for the first time. In the presence ofelectron-deficient olefins, however, 2-(2-phenylethenyl)pyridinium N-ylides underwent1,3-dipolar cycloadditions and then aromatized in situ by TPCD to produce indolizinederivatives, indicating 1,3-dipolar cycloaddition proceed more readily than 1 ,5-dipolarcyclization in these conditions. Pyridinium disubstituted N-ylides, readily obtainedfrom corresponding pridinium and β-chlorovinyl ketone, underwent thermalintramolecular 1,5-dipolar cyclization to give indolizine derivatives easily.Indolizinecarbaldehyde derivatives were synthesized starting from 2-pyridinecarbaldehyde in four-steps involving 1,3-dipolar cycloaddition reaction.

本文首次研究了2-(2-芳基乙烯基)吡啶N-叶立德在氧化剂存在下的分子内1，5-偶极环化反应，采用一锅法合成了中氮茚衍生物；研究了这些N-叶立德的1，5-偶极环化和1，3-偶极环加成反应的选择性，发现当有缺电子烯烃存在时，优先进行1，3-偶极环加成反应，而不再发生分子内1，5-偶极环化反应；由β-氯乙烯酮方便地得到了烯丙基N-叶立德，他们在加热时进行分子内1，5-偶极环化反应而得到中氮茚衍生物；由2-吡啶甲醛为起始原料，通过1，3-偶极环加成反应等四步反应，得到了重要的中氮茚甲醛衍生物，这些反应都具有条件温和和操作简便的特点，是合成中氮茚衍生物的新方法。

This means that a lot of people who have a Net presence have a legally encumbered Net presence.

这就意味着很多拥有网络身份的人却在法律上受到了限制。

"I don't say that the difficulties we are experiencing round the world are caused by our presence in Iraq, but undoubtedly our presence in Iraq exacerbates them."

&我没有说我们在世界上所遇到的麻烦是由于在伊拉克驻军引起的，但是毫无疑问我们在伊拉克的驻军加剧了这些麻烦的程度。&

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。