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It has been demonstrated that TAK-147 is more potent and brain-specific AChE inhibition than tacrine and physostigmine, and has been approval potentiating choline acetyltransferase activity in cultured rat septal neurons more potent than donepezil, tacrine and revastigmine.

TAK－147 ｛ 3－［l一（phenylmethyl（－4－piperidinyl］－l一门，3，4，5－tetrahydro－IH－l－be.azepln－8－yi（－l－propanone umarate ｝是日本最近研制的一个选择性胆碱酯酶抑制剂。TAK－147与毒扁豆碱和他克林相比是具有更强作用和中枢选择性的胆碱酯酶抑制剂。

Endothelial cells produce potent vasodilators and the most potent vasoconstrictor, endothelin.

内皮细胞产生强烈的血管扩张素和最强烈的血管收缩素――内皮素。

Replacement of one benzimidazole fragment with benzothiazole or benzoxazole and optimization of the structure to create the new frame of the compounds were also carried out with the exception to find more potent compounds. The purpose of design and synthesis of these compounds is to investigate the QSAR of this class of compounds with the inhibition of HCV NS3/NS4A protease and eventually to develop more potent inhibitors.

本文首次采用了丙二酰胺与邻芳二胺在微波辐射下制备对称性双芳并唑甲烷化合物、用芳并唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性双芳并唑甲烷化合物、用4-取代噻唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性(4-取代-噻唑-2-基)(1H-芳并咪唑-2-基)甲烷化合物等合成路线，共合成了48个目标化合物，其中41个为新化合物，用~1HNMR，ESI-MS，FT-IR，元素分析对这些化合物进行了全面表征，确定了这些化合物的结构，并对部分化合物进行了~(13)CNMR分析。

The most potent compound 8 showed potent antiproliferative activity with IC50 values of 80 nM against human KB oral epidermoid carcinoma cell line.

最有活性的化合物8，在人类口腔上皮肿瘤细胞株的IC50 达到80 nM。

Further, at concentrationssimilar to the maximum therapeutic plasma concentrations (10–7 mol/L olprinone; 10–6 mol/L milrinone; 10–5 mol/Lamrinone) olprinone and milrinone were more potent at inducingrelaxations than amrinone in gastroepiploic arteries and radialarteries, whereas in internal mammary arteries milrinone wasmore potent than the others.

此外，在与最大治疗血浆浓度相近似的浓度中（10–7 mol/L 的奥普力农、10–6 mol/L 的米力农、10–5 mol/L 的氨力农）时，奥普力农和米力农对胃网膜和挠动脉的舒张作用比氨力农强；而对乳内动脉，米力农的舒张作用比其它两者更强。

The inhibition effect of chloroform fraction was the most potent, with the inhibition rate about more than 83% to 5 plant pathogenic fungi under the concentration of 15mg/mL. Under the concentration of 15mg/mL, the ethyl acetate fraction and n-butanol fraction thoroughly inhibited the growth of Alternaria solani and Valsa mali, with the inhibition rate up to 100%. The n-butanol fraction showed the highest potent virulence, with EC50 to Alternaria solani and Valsa mali about 0.09 and 0.279 mg/mL respectively.

其中氯仿部分的抑菌效果较好，当质量浓度为15mg/mL时，其对5种植物病原菌的抑制率均在83%以上；15mg/mL乙酸乙酯部分和正丁醇部分分别对番茄早疫病菌和苹果腐烂病菌有强烈且稳定的抑制作用，抑制率达100.00%，正丁醇部分对这两种菌丝生长抑制毒力最好，EC50分别为0.090和0.279mg/mL。

L-1 (10-7mol . L-1) noradrenaline induced contraction of rat aortic strip was taken as criterion. Compound I5 was shown to be a potent potassium channel activator. Compound II8 exhibited calcium antagonistic activity and showed potent vasodilating activity.

引起的大鼠主动脉条收缩有较好的抑制作用，其中化合物 I5的钾离子开放活性与尼可地尔相当，化合物 II8显示有钙离子通道拮抗活性，并有较强的扩血管活性。

Beauty is potent, but money is more potent.

美丽是有力量的，但金钱更有权威。

85 And 119486/79. They are a novel type of antibiotic having both the wide antibacterial spectrum and high safety of penicillin and cephem antibiotics belonging to beta -lactam antibiotics, as well as the potent antibacterial activity and high beta -lactamase stability of carbapenem antibiotics.Sodium-(5R, 6S)-6-[-1-hydroxyethyl]-7-oxo-3- [-2-tetrahydrofuryl]-4-thia-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylate 5/2 hydrate (faropenem sodium, hereinafter referred to as compound 1) is currently used as an oral drug for various infectious diseases and is reported to show potent antibacterial activity against not only methicillin-sensitive Staphylococcus aureus, Streptococcus pyrogenes and Streptococcus pneumoniae but also gram-positive bacteria for which conventional beta -lactam drugs have proved ineffective such as penicillin-resistant pneumococci, oral staphylococci and enterococci, also showing a wide antibacterial spectrum covering gram-negative bacteria such as Haemophilus influenzae and anaerobic bacteria such as the genus Bacteroides, which activity is due to its novel skeleton penem ring (Kagaku Ryoho no Ryoiki The Field of Chemotherapy, Vol.

他们是一种新型的抗生素都具有广泛的抗菌谱和高度的安全青霉素和cephem抗生素，属于β-内酰胺类抗生素，以及作为强大的抗菌活性和高β-内酰胺酶稳定的碳青霉烯类antibiotics.sodium -（ 5 R ， 6 S ）-6 -[ - 1 -羟乙基] - 7 -氧- 3 - [ - 2 - t etrahydrofuryl] - 4 -硫杂- 1 -氮杂双环[ 3 。2.0]庚- 2 -节能- 2 -羧酸5 / 2水合物（法罗培南钠，以下简称为化合物1 ）是目前用来作为口服药物，为各种传染病和报道，以显示强大的抗菌活性，不仅对甲氧敏感的金黄色葡萄球菌，链球菌pyrogenes和肺炎链球菌，但也克阳性菌为常规β-内酰胺类药物已证明无效，如青霉素耐药pneumococci ，口腔葡萄球菌和肠球菌，也显示出广泛的抗菌谱，包括革兰阴性菌如流感嗜血杆菌和厌氧菌如属杆菌，这活动是由于其新颖的骨架青霉烯环（（化学ryoho没有ryoiki领域的化疗），第13卷，第10号，第74-80 ， 1997年）。

Fisher single-handedly opened a new world of human knowledge by subjugating nature's most potent force -- evolution -- with humankind's most potent tool -- mathematics.

他解出了控制信息传播的方程。费希尔通过使用人类最强有力的工具——数学，征服了自然界最强大的力量——进化，从而独立打开了人类知识的新世界。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。