查询词典 polysomy

Polysomy, which includes trisomy, is the condition in which one or more chromosomes are represented more than twice in the cell.

多染色体包括三染色体都是一条或多条染色体代替了正常细胞中的两条染色体形成的。

Purpose: Polysomy 17 is frequently found in breast cancer and may complicate the interpretation of HER-2 testing results.

但是，17号染色体多体会对HER2状态检测结果解读造成很大的影响。

And the one with both amplification of HER2 gene and polysomy of chromosome 17 was also moderately positive expression for the protein.

FISH技术可稳定地检测用IHC确定的HER2蛋白阳性乳腺癌中HER2基因的扩增状况，并用于临床赫赛汀分子靶向治疗病例的筛选。

We investigated the impact of polysomy 17 on HER-2 testing and studied its clinicopathologic significance in relation to HER2 gene amplification.

该研究的FISH结果显示，44例患者的HER2绝对拷贝数达可疑阳性，但如果结合17号染色体多体因素(HER2/Chr17)，这些患者均为HER2阴性。

On its own, polysomy 17 was not associated with HER-2 overexpression on IHC or increased HER2 mRNA levels by RT-PCR. Moreover, and in contrast with HER2 gene amplification, polysomy 17 was not associated with high tumor grade, hormone receptor negativity, or reduced disease-free survival.Conclusion: Polysomy 17 affects HER-2 testing in breast cancer and is a major cause of equivocal results by FISH.

不过，在J Clin Oncol同期配发的一篇述评中，美国波士顿大学医学中心的罗森伯格指出，当务之急不是直接进行这样的研究，而是应该对已有研究的IHC、FISH和有效率数据进行回顾或再分析，以明确是否无HER2扩增的17号染色体多体肿瘤被归入不同类别(HER2阴性、阳性)，并由此导致关于HER2靶向治疗疗效的结果不一致。

We show that tumors displaying polysomy 17 in the absence of HER2gene amplification resemble more HER-2–negative than HER-2–positive tumors. These findings highlight the need for clinical trials to investigative whether polysomy 17 tumors benefit from HER-2–targeted therapy.

在他看来，若要进一步改进乳腺癌靶向治疗的患者选择和转归，遗传和药理学基础研究、已有研究数据再评价以及肿瘤早期HER2变异研究需要齐头并进。

The concept of equivalent rotationally rigidity is offered and the formula of rotationally rigidity is obtained.

主要做了如下几个方面的工作：对伸臂位于顶部的单层框架—筒体模型进行分析，提出了等效转动约束的概念和转动约束刚度的表达式。

Male cats normally do not need aftercare with the exception of the night after the anesthetic.

男猫通常不需要善后除了晚上的麻醉。