查询词典 pituitary

POU1F1 is the first certified pituitary transcription factor, it plays a role in control ofgrowth process and metabolism, it has far-ranging biological functions in improvinggrowth, reducing fat aggradation and so on.

POU1F1(pituitary transcription factor 1)是被鉴定的第一个垂体转录因子，它对哺乳动物的生长发育、新陈代谢起重要的调节作用，具有提高生长速度，降低脂肪沉积等广泛的生物学功能。

Objective: To explore the pituitary function of acute pituitary apoplexy and its effect by transsphenoidal surgery.

目的探讨急性垂体卒中患者在经蝶手术前后的垂体功能的变化情况。

Based on the understanding of physiological pathway for broodiness, three genes related to broodiness including PRL, PRL receptor, and pituitary-specific transcription factor (POU1F1)-encoding genes were selected as candidates to screen the genomic variation by means of PCR-SSCP protocol and analyze the association with chicken broodiness and other target traits.

禽类血浆PRL水平上升与就巢行为的起始和维持具有密切的相关性，本研究采用候选基因的策略，通过分析就巢行为发生的生理机制，选择与就巢性状密切关联的PRL、PRL受体和PRL转录调控因子——垂体特异转录因子(pituitary-specific transcription factor，POUlF1)基因，采用PCR-SSCP分析检测基因变异，并分析基因变异与就巢性和其它目标性状的相关性。

Cd〓 (1, 10, 100, 1000μM) stimulated directly GtH secretion from pituitary of common carp in vitro, with the highest GtH secretion at 100μM, GtH secretion stimulated with 1000μM Cd〓 was not higher than that stimulated with 100μM Cd〓.The antagonism between Ca〓 and Cd〓 in perfusion of the pituitary fragments was not obvious.After being preperfusion with 100μM Cd〓(with or without Ca〓), the GtH secretion of the pituitary fragment was irresponsive to 2-min pulse stmulation of 10μM sGnRH-A.

鲤鱼脑垂体碎片离体灌流孵育实验结果显示，Cd〓（1，10，100，1000μM）可直接刺激鲤鱼脑垂体分泌GtH，灌流液中Ca〓对Cd〓的拮抗作用不明显，100μM Cd〓刺激脑垂体分泌GtH达到高峰，Cd〓浓度增加到1000μM时，脑垂体分泌GtH并没有进一步增加，甚至有减少的趋势；100μM Cd〓预灌流脑垂体后，可使脑垂体对2-min 10μM sGnRH-A刺激的反应性消失；1.25mM的EDTA可消除100μM Cd〓刺激脑垂体分泌GtH的作用；TFP和Cd〓同时灌流脑垂体一段时间后，撤除TFP可使脑垂体分泌GtH显著增加，即出现"反跳"现象。

ASCL2 gene escapes genomic imprinting in skeletal muscle,fat, heart,liver,spleen,lung,kidney,stomach,small intestine,uterus,ovary and pituitary.(2) Both of the transcripts of NNAT gene is paternally expressed in skeletal muscle,fat,heart, liver,spleen,lung,kidney,stomach,small intestine,uterus,ovary and pituitary.(3) DIRAS3 gene is paternally expressed in skeletal muscle,fat,heart,liver,spleen,lung, kidney,stomach,small intestine,uterus,ovary and pituitary.(4) DLX5 gene is maternally expressed in skeletal muscle,fat,spleen,lung,stomach,small intestine,but escapes imprinting in heart,liver,kidney,uterus,ovary,testicle and pituitary.

1ASCL2基因在肌肉、脂肪、心、肝、脾、肺、肾、胃、小肠、子宫、卵巢和垂体中均逃脱印记；(2)NNAT基因两个转录本在肌肉、脂肪、心、肝、脾、肺、肾、胃、小肠、子宫、卵巢和垂体中均为母系印记：(3)DIRAS3基因在肌肉、脂肪、心、肝、脾、肺、肾、胃、小肠、子宫、卵巢和垂体中母系印记：(4)DLX5基因在骨骼肌、脂肪、肺、脾、胃和小肠中表达母本来源的等位基因，即表现为父系印记；而在心、肝、肾、子宫、卵巢、睾丸和垂体中表达双亲来源的等位基因，即逃脱印记。3。

In order to investigate the effect of IFN-γon the expression of TNF-αin the hypothala- mus-pituitary-ovary axisof RU486-induced aborted SD rats, RU486 was used to establish the abortion model, then the aborted rats were administrated with different doses of IFN-γintraperitoneal injection, the method of immunohistochemical ultrasensitive SP was us- ed to study the variation of positive TNF-αcells in hypothalamus, pituitary, ovary and uterus in normal pregnant group A, aborted model group B and three different doses of IFN-γgroup C,D,E. The main goal of this research was to study whether the low dose of IFN-γcould have a protective function to pregnancy and the mechanism of its function so as to provide morph- ologic basis for the scientific using of IFN-γin the process of animal abortion control.

为探讨IFN-γ对流产大鼠下丘脑-垂体-卵巢轴(hypothalamus-pituitary- ovary-axis，HPOA )TNF-α表达的影响，本试验用米非司酮(RU486)建立SD大鼠流产模型，通过腹腔注射不同剂量IFN-γ，采用超敏感免疫组织化学SP法(链霉素抗生物素—过氧化物酶法)，观察了孕13天(d13)SD大鼠正常妊娠A组、流产模型B组、不同剂量IFN-γC、D、E组下丘脑、垂体、卵巢、子宫TNF-α的表达变化，探讨低剂量IFN-γ对妊娠是否有保护作用及其作用机制，期望能为在妊娠过程中如何科学应用IFN-γ防止动物流产提供形态学依据。

The results showed that (1) the positive staining of ChAT was obviously observed in the cells of the three kinds of human pituitary adenoma, however, it was lower than that in normal human pituitary gland;(2) ACh had a similar effect on the proliferation of the three kinds of human pituitary adenoma cells. ACh at 0.1～10 μmol/L decreased the ［3H］TdR incorporation and the MTT A value in a dose-dependent manner. At the same time, ACh decreased the ratio of S or G2 phase pituitary adenoma cells significantly, but increased the ratio of G1 phase pituitary tumour cells markedly;(3) the effect of acetylcholine on the proliferation of human pituitary adenoma cells was inhibited by atropine, but not by tubocurarine;(4) ACh had no effect on the apoptosis of human pituitary adenoma cells cultured in vitro.

结果发现：(1)三种垂体腺瘤细胞中均有胆碱酯酶的表达，但明显少于正常垂体；(2)ACh对三种类型的人垂体腺瘤细胞增殖代谢的影响相类似，不同浓度的ACh能明显抑制体外培养的三种人垂体腺瘤细胞的增殖，呈明显的剂量效应关系，同时ACh能减少垂体腺瘤细胞进入S、G2期的细胞比例，而使处于G1期的细胞比例增加；(3)ACh的这种作用可被阿托品阻断，但不受筒箭毒的影响；(4)ACh对体外培养的三种人垂体腺瘤细胞凋亡无明显影响。

Its a practical method to classify pituitary adenoma with a combination of multi-measures: immunohistochemistry, ultrastructure and endocrinal characteristics; Nm23, Ki-67 and microvessel density play an important role in the biological behaviour of pituitary adenoma, and there exist co-relations between the three. The examination of the three helps to determine the biological behaviour of pituitary adenoma, as well as to supervise treatment and prognostic evaluation.

应用免疫组化激素检查、电镜超微结构观察并参考临床内分泌特征对垂体腺瘤进行形态和功能分类为具有实际应用价值的分类方法；nm23、Ki一67和MVD在垂体腺瘤的生物学行为中起重要作用，并且三者在垂体腺瘤中的表达有一定的相关性，三者联合表达的检测有助于判断垂体腺瘤的生物学行为及临床治疗和预后评估。

Patients with pituitary adenoma (84 PRL-secreting pituitary adenomas, 30 GH-secreting pituitary adenomas and 36 nonfunctioning pituitary adenomas) were treated by adnomectomy. The dynamic studies of serum PRL, GH, Cortisol, ACTH and thyroidal functions (T3, T4, TSH) were performed before and after microsurgery.

为了解垂体瘤手术对垂体激素分泌的影响，动态观察了150例垂体瘤患者在显微外科手术前后血清泌乳素、生长激素、甲状腺功能〔T3、T4、促甲状腺素〕、血皮质醇和促肾上腺皮质激素的变化。

Methods samples from 78 patients with pituitary adenomas, including 37 invasive and 41 noninvasive, and 5 normal pituitary tissue specimens from autopsied patients were examined. the expressions of opn mrna and opn were examined by real-time fluorescence quantitative pcr and immunohistochemical sp method, respectively. the relation of opn and opn mrna expressions to invasiveness of pituitary adenomas was analyzed.

分别对78例垂体腺瘤手术标本（其中侵袭性37例，非侵袭性41例）和5例来源于尸检的正常垂体组织进行检测，采用实时荧光pcr技术检测组织中opn mrna表达，免疫组织化学sp法检测opn蛋白表达，结合临床资料分析opn mrna及其蛋白的表达与垂体腺瘤侵袭性的关系。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。