查询词典 phenylglycine

Owing to the abroad application of Candida rugosa lipase in the resolution of racemic aminoacides, the prepared lipase was used in the resolution of phenylglycine and tert-leucine. Through the optimization of the reaction conditions, such as reaction substrate, pH, temperature, ion strength and additives, enantiomeric excesses for phenylglycine and tert-leucine reached 96% and 90.1%, respectively, enantiomeric ratio came up to 28. 9 and 15. 4, respectively.

鉴于该酶广泛应用于手性化合物的拆分研究，本论文中选用了两种手性氨基酸作为拆分对象，通过对反应体系中一系列条件的优化，包括底物、pH、温度、离子强度以及添加物的使用，苯甘氨酸和叔亮氨酸的对映体过量值分别达到96%和90.1%，对映催选择率分别达到28.9和15.4。

A HPLC method was established for the determination of the L-α-Phenylglycine and related substances in L-Dihydrophenylglycine sodium salt.

双氢苯苷氨酸甲基邓钠盐中α-苯苷氨酸残余含量在高压液相色谱条件下进行检测。

The technology of preparation of chiral phenylglycinol from chiral phenylglycine is turned out to be a technical platform which can prepare many kinds of aminoalcohol through repeated experiments of the small scale test.

并且经过实验室小试反复测试，证明由手性苯甘氨酸制备手性苯甘氨醇工艺有技术平台式作用，可用于各种氨基醇类化合物的合成。

The immobilized enzyme from Bacillis megaterium gave a better catalytic properties and the higher conversion was obtained using phenylglycine methyl ester as acyl donor.

来源于巨大芽孢杆菌的固定化酶催化头孢克罗合成的能力较好，以苯甘氨酸甲酯为底物较酰氨的效果好。

In a system consisting of 20% PEG 400 and 12% magnesium sulfate, the partition coefficient of PGA was less than 0.01, PGA almost completely partitioned into the magnesium sulfate-rich bottom phase. Meanwhile, the partition coefficient of cephalexin was 6.7, the partition coefficients of phenylglycine methyl ester and 7-ADCA were 1.5 and 1.2, respectively.

通过考察头孢氨苄、苯甘氨酸甲酯和7-氨基脱乙酰氧基头孢烷酸(7-ADCA)在ATPS中的分配行为建立了一个含20%PEG 400和12%硫酸镁的ATPS，在此体系中头孢氨苄的分配系数为6.7，苯甘氨酸甲酯的分配系数为1.5，7-ADCA的分配系数为1.2，且青霉素酰化酶的分配系数小於0.01。

Enzymatic synthesis of cefaclor from 7\|aminodesacetoxymethyl\|3\|chlorocephalosporanic acid (7\|ACCA) and phenylglycine derivatives using penicillin G acylase was studied.

以7-氨基去乙酰氧甲基-3-氯头孢烷酸(7-ACCA)和苯甘氨酸衍生物为底物，利用青霉素酰化酶酶促合成头孢克罗。

Chiral separation of D -, L -phenylglycine by RP-HPLC was accomplished by adding a complex of optically active L -Phe-Cu2+ to the mobile phase. Chiral separation mechanism was further elucidated in light of unambiguously assigning the structure of the elutents from RP-HPLC by taking advantage of tandem mass spectrometry due to its unique capability of structural identification of the unknows.

以含 L -苯丙氨酸铜配位络合物的溶液作为手性流动相，采用反相高效液相色谱法拆分了非衍生苯甘氨酸对映体，使用质谱对拆分组分进行了结构鉴定，得到了拆分组分的化学结构，用量子化学计算预测了该结构的最稳定构象。

Furthermore,enzymatic production of cephalexin using free penicillin G acylase in aqueous system wasstudied. The parameters, including pH, temperature, concentration of 7-ADCA and molar ratiosof 7-ADCA to phenylglycine methyl ester, that affect the yield of cephalexin, wereevaluated. In section Ⅱ, the integration technique of bioseparation and biosynthesis was investigatedfirst time in the enzymatic production of cephalexin.

第Ⅰ部分主要建立了对酶法合成头孢氨苄过程行之有效的HPLC检测方法，实现了头孢氨苄合成过程中所涉及的四种物质，即头孢氨苄、苯甘氨酸甲酯、苯甘氨酸及7-ADCA快速有效的检测；同时对水相体系中头孢氨苄合成过程的影响因素进行了研究，明确了水相体系中温度、pH值，底物浓度以及底物配比对酶法合成头孢氨苄得率的影响。

Therelationship of the amount of catalyst and the ee% of product was seen to be negative nonlin-ear. Catalyst 3 was used in the enantioselective addition of diethylzinc to aromatic aldehydesand gave good results. The configuration of products was determined by the configuration ofthe catalysts' chiral carbon linked with hydroxy group. Using β- amino alcohols bearing only one chiral center as catalysts for the enantiose-lective addition were studied. D-N, N-dialkyl-2-amino butanol gave poor catalytic effect be-cause of their structure. The configuration of the product is the same as the catalyst. Anotherkind of β- amino alcohols - phenylglycine derivatives and valine derivatives have chiralcenter on the carbon linked with amino group. Catalyzed by-phenylglycine derivatives 6,7, 9, 10, the reactions gave satisfied results. The optical yields exceeded 80%.

在探讨了含有两个手性中心的β-氨基醇之后，选择了只有一个手性中心的β-氨基醇，一是手性中心为连羟基的手性碳原子：D-N，N-二烷基-2-氨基丁醇；二是手性中心为连氨基的手性碳原子：D-苯基甘氨酸衍生物和L-缬氨酸衍生物。D-2-氨基丁醇的催化效果不太好，这与其结构的空间位阻较小有关系，反应产物与连羟基手性碳构型一致；由苯基甘氨酸和缬氨酸出发合成五种β-氨基醇6-10，研究了不同ee％的-6作用下的二乙基锌-苯甲醛加成反应，发现该催化剂具有不对称放大效应；-7，9，lO的催化效果也比较令人满意，光学产率80％以上，所得产物构型与催化剂构型一致。

Several trivalent (boron, aluminium, iron, arsenic and antimony) and tetravalent metal/non-metal derivatives of N-(2-methyl) phenylglycine have been prepared by the interaction of their corresponding isopropoxide with the latter in 1:1 and 1:2 molar ratios in benzene medium.

用N-(2-甲基)苯基甘氨酸合成了几种及四价金属/非金属衍生物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。