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In the area of sexual health, VIVUS is in phase 3 development with avanafil, a potentially best-in-class PDE5 inhibitor, and in phase 2 development of Luramist for the treatment of hypoactive sexual desire disorder in women.

在性健康， VIVUS是在第3阶段发展avanafil ，一个潜在一流的PDE5抑制剂，并在第2阶段发展Luramist ，用于治疗性欲障碍的妇女。

In the study of defect problems in elastic media, first, the uniform stress fields within a three-phase anisotropic elliptic inclusion in anti-plane shear is discussed; second, an exact solution is given for an edge dislocation in a three-phase composite cylinder model with a sliding interface; finally, an analytic solution is derived for two circular inclusions with circumferentially inhomogeneously imperfect interfaces interacting with a circular Eshelby inclusion in anti-plane shear.

在对弹性介质缺陷体问题的讨论中，我们首先探讨了面外剪切变形下各向异性三相椭圆夹杂中均匀应力场；其次研究了具有滑动界面的三相圆柱复合模型中的刃型位错问题；最后分析了面外剪切下具有环向非均匀界面的两个圆柱异相夹杂与一个圆柱Eshelby夹杂的相互作用问题。

Results:①The amount of human colon carcinoma cell line SW480 treated by quercetin decreased. The morphology of partial SW480 cells was shrunk volume, integrated cell membrane, condensed cytoplasm, pyknotic chromatin, nuclear fragmentation. Apoptotic Corpuscles were found by electron microscope.②MTT colorimetric assay showed quercetin inhibited the growth of human colon carcinoma cell line SW480 in a time- and dose-dependent manner when the concentration of quercetin was 30、60、90μmol/L.③Flow cytometry analysis showed the cell cycle of SW480 cell was restricted in G1/S. G0/G1 phase rate increased and S phase rate decreased with increasing concentration of quercetin and time lasting.④ Zymogram analysis assay showed the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480 treated by quercetin decreased. With increasing concentration of quercetin, the secretion of MMP-2 and MMP-9 decreased.⑤Immunohistochemistry method demonstrated the position expression of Cathepsin-D in SW480 cell was suppressed by quercetin in a time- and dose-dependent manner.

研究结果：经槲皮素处理的人结肠癌SW480细胞数量减少，部分细胞体积缩小，细胞膜完整，胞浆浓缩，核染色质固缩，细胞核碎裂，形成凋亡小体；MTT法检测显示当作用浓度为30μmol/L~90μmol/L时，槲皮素对人结肠癌SW480细胞的生长有抑制作用，其抑制作用随着作用浓度的增加和作用时间的延长而增强；流式细胞学发现槲皮素主要作用于人结肠癌SW480细胞周期的G1/S期，大部分细胞被阻断于S期，随药物浓度的升高和作用时间的延长，G0/G1期细胞比例逐渐增加，S期细胞比例逐渐减少；酶谱分析法检测显示不同浓度的槲皮素能够抑制人结肠癌SW480细胞分泌MMP-2及MMP-9，随浓度的升高，MMP-2及MMP-9的分泌量减少；免疫组织化学法显示不同浓度的槲皮素处理人结肠癌SW480细胞后，Cathepsin-D的表达随药物浓度的升高和作用时间的延长而降低。

In the interfacial layer near to SiC, elements Pd and Ni preferentially diffused to SiC and resulted in the reaction products of Pd-Si phase, Ni-Si phase and graphite. In the reaction zone further away from the SiC, mainly elements Cr and V in the brazing filler participated in the interface reaction, and formed Cr-C, Cr-Si, Cr5Si3C. In the central part of the joint, the matrix was composed of Pd-Si, Ni-Si and V-Si phases, on which some blocky carbides V2C, Cr23C6 distributed scatteringly.

MPa。微观分析表明，在靠近SiC的界面反应层中，主要是Pd和Ni优先与SiC反应生成相应的Pd-Si相，Ni-Si相和石墨；接头中在离SiC稍远的区域，主要是Cr和V与母材扩散进入钎缝且未与Pd和Ni反应的C和Si发生反应，生成Cr-C， Cr-Si， Cr5Si3C 等相；钎缝中心区的基体由Pd-Si，Ni-Si和V-Si相组成，其上弥散分布着块状碳化物V2C和Cr23C6。

In this paper, arrangement scheme of a novel multi-star phase shifted pole changing coil was given and the methods to determine coil split ratio were analyzed. According to electromagnetic theory, 2D electromagnetic mathematical model in which stator windings were spitted coil was developed, and magnetic field distribution of the novel motor at starting was solved by finite element method, starting performance of motor was calculated. Based on energy method, rotor slot leakage reactance under different poles and different loads were calculated, and the variation of rotor slot leakage reactance with loads was gotten. Based on time-step finite element method, distribution of branch current in stator windings and operating performance were calculated and analyzed when branch was unbalance, the method to calculate circulating loss in stator windings of novel multi-star phase shifted pole changing motor was given, and the effects of the loads variation and degree of unequilibrium on circulating loss in stator windings were calculated and analyzed.

论文系统的给出了采用分裂线圈法新型多星形移相变极绕组的排列方案，进一步分析线圈分裂比的确定方法；根据电磁场理论，建立了定子为分裂线圈绕组的电机二维电磁场数学模型，并采用场路耦合法求解了新型多星形移相变极电机起动时的磁场分布，计算了电机起动性能和基于能量法计算了不同极数下起动时转子槽漏抗和不同负载时转子槽漏抗，得出转子槽漏抗随负载变化的规律；采用时步有限元法计算分析了定子绕组支路不平衡时支路电流的分布情况及运行性能，给出了新型多星形移相变极电机定子绕组环流损耗的计算方法，分析比较了负载的变化和支路不平衡度大小对定子绕组环流损耗的影响。

At the super-low permeable reservior sandstone of Fu and Yang in Daqing Oilfield, many pore throats exist a lot in the types of compacted and restored flakes and curved lamellas while the pore volume of micropore and the thin, compacted and shrunken throat that contribute little to flow take large scale in the total pore space. Thereof high filtrational resistance is caused by much trouble including high content of reservoir shale, serious sensibility to pressure at waterflooding, remarkable effects of undersaturation and water blocks in micropore. A method with laboratory experiment, theoretical confirmation and field application included was adopted to analyze the non-linear flow characteristics, to reveal the deep mechanism of pinhole enveloping macropore and to provide a new technology of improving the development effect. The outcomes aquired are as follows: Multiple cores with different low and super-low permeability were selected to perform seepage experiments by gas, water and oil. Three fields of flow were observed in the reservoir at different low and super-low core permeability. They are pseudo- elastic flow, transition flow and plastic creep flow. So the concept that there was no correlation of rocky absolute permeability with fluid properties that pasted itself was broken up. Two-phase seepage of water displacing oil in uniform super-low permeability shows that the two-phase seepage zone is narrow.

针对大庆油田扶、杨特低渗透油层砂岩孔隙喉道的大小和形态以压实再生型片状、弯片状喉道分布较广，压实、缩小型细喉道型，微孔不可流动的孔隙体积所占总孔隙体积的比例较大的特点；及储层泥质含量高，注水开发中压力敏感性强、微孔隙欠饱和及水锁效应显著，导致流体渗流阻力增大的问题，本文采用室内实验、理论推证和矿场应用相结合的方法，研究、分析了流体非线性渗流特征，更深刻地揭示出小孔包围大孔的机理及产生原因，并提供了改善开发效果的新的技术方法，取得如下成果：选择不同渗透率的低渗透、特低渗透岩心，进行了气、水和油单相渗流实验，揭示出当岩心渗透率不同时，油层内的流体呈现出拟弹性流变、过渡流变、塑性蠕变三种流变区，从而打破了岩心的绝对渗透率与通过岩心流体性质无关的观点；同类特低渗透岩心的水驱油两相渗流实验表明，两相渗流区较窄。

Mitochondria cristae and membrane in a great measure were anastomosis or vacuolization.Conclusion: All these results suggest that effects of H2S on papillary muscles are due to an increase in potassium efflux through opening the KATP channels at the early phase of ischemia, and acceleration in potassium reuptake through improving the Na+-K+-ATPase at the late phase of ischemia. Endogenous H2S may act as important regulator in electrophysiological characters in ischemic papillary muscles.

外源性H2S前处理可能通过兴奋KATP通道促进缺血早期K+外流，并且由于对Na+-K+-ATP酶的保护作用改善了缺血晚期对K+的重摄取，进而影响缺血环境下豚鼠乳头状肌细胞的电生理效应；乳头状肌细胞内源性产生的H2S可能在心肌缺血损伤时发挥着重要的电生理作用。

In order to simply the method, we further propose using magnetic stirring with weighted ring in stead of argon sparging; using air-circulated incubator in stead of water bath for better observation and sample collection; using centrifuging in stead of filtration for extract pretreatment; using one phase of simplified bioaccessibility extraction method instead of the two-phase method for a better estimate to the in-vivo method.

爲进一步简化试验方法，建议将开放式反应槽改为密闭式；使用可调速磁力搅拌及具载重环磁石，取代昂贵之氩气搅拌；将水浴温控改为气控式，以利试验观察与采样。此外，小肠相萃取不使用吸附剂，萃取液前处理利用高速离心取代压阻较高之过滤方式。本研究二阶段试验之生物有效性皆低估动物试验RBF，建议可将二阶段胃肠体外试验方法改为单相一阶段生物有效性萃取(simplified bioaccessibility extraction， SBET)试验方法。

High load high temperature resistant, good performance, and braking stability, mud in winter and bad conditions, the disc brake driving drum brake easier than in a relatively short period of time to stop the car Can collapse in vehicle principls shrinkage occurs when the frontal impact crushing forward, to ensure the shrinkage crew chest from harm CAE simulation technology for application of the original design, the change process, CAE analysis method and combining with engineering design, analysis and design, CAE and the integration of CAD most of the vehicle in the design phase problems can be resolved through simulation, can be in concept design phase is accurately forecast and control components and vehicle performance and reliability, thus in the development initial can make the future product performance and structure index guaranteed.

高负载时耐高温性能好，制动效果稳定，而且不怕泥水侵袭，在冬季和恶劣路况下行车，盘式制动比鼓式制动更容易在较短的时间内令车停下可溃缩式转向柱会在车辆发生正面碰撞的时候向前溃缩，以保证乘员胸部免受伤害 CAE仿真技术进行的全面应用，改变了原来的设计方法和流程，CAE分析和工程设计紧密结合，实现了分析与设计同步、CAE与CAD的一体化使车辆的大多数问题都可以在设计阶段通过仿真得到解决，可以在概念设计阶段就精确地预测和控制零部件乃至整车的性能和结构可靠性，从而在开发初期就能使未来产品性能和结构指标得到保证。

Maintenance in both natural and short photoperiods during the restoration phase, pikas showed significantly increased the gonadal masses than the field collection group in the early ten days of Feburary (P.01). While maintenance in the upper two photoperiods during in the sexually quiescent phase, pikas didn't show signigficently increased in gonadal masses than the field collection group in the last ten days of December.

在不同光制对鼠兔生殖内分泌功能影响的研究中，1月下旬捕获的鼠兔，在自然光（L/12 h）和短日照条件下饲养49天以后，性腺器官也呈现显著萌发并产生成熟配子的现象；而在9月中旬捕获的鼠兔，在上述光周期条件下饲养81天后，却呈现显著抑制性腺功能的作用。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。