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In this study, the genomic structure and regulatory elements of ApoD from 10 representive species including protozoan, invertebrate, protochordate and vertebrate were analyzed and compared. The genomic structure of ApoD is less conserved in organisms from protostome to deuterostome invertebrates, while it is highly conserved among chordates including amphioxus and verebrates. All four conserved cysteine residues are present in amino acid sequence of deuterostome ApoDs, while there are only two cysteine residues in amino acid sequence of protostomes ApoD. Structure divergence between protostome and deuterostome ApoD proteins suggests their function difference. The majority of regulatory elements are present in nearly all organism ApoD genes ranging from unicellular protozoan to mammals, suggesting that ApoD plays a very fundamental role, and possesses a conserved regulatory mechanism. However, there also exist some specific regulatory elements, which are present only in certain species and may perform some special roles.ApoD mRNA expression in murine NIH/3T3 fibroblasts exposed to various stresses such as as hydrogen peroxide and UV light shows dose-dependent increase. And a fly homolog of ApoD, Glial Lazarillo, whose overexpression results in increased resistance to hyperoxia as well as a extension of lifespan under normoxia and resistance to starvation without altering lipid or protein content.

本文首先从生物信息学角度对分属于原生动物、无脊椎动物、头索动物和脊椎动物类群的10种动物ApoD的基因结构及调控区的调控元件进行分析及比较,发现:(1)ApoD基因外显子-内含子结构从原生动物草履虫到原口动物再到后口动物海胆的进化过程中不保守,但在分析的几种脊椎动物中相当保守;(2)文昌鱼ApoD基因扮演从无脊椎动物到脊椎动物承上启下的角色,可能代表了脊椎动物ApoD基因原型;(3)四个半胱氨酸保守位点在后口动物中都存在,而在原口动物中只存在两个,原口、后口动物ApoD蛋白一级结构上的差异反映蛋白功能上可能也存在一定差别;(4)调控区大多数主要调控元件为不同动物共有,说明ApoD主要功能及其表达调控在进化中相当保守;(5)ApoD基因个别调控元件是随着物种进化而出现并开始发挥相关作用,如SF-1;还有一些调控元件在进化过程中还没有发现其规律,这说明ApoD某些功能和基因表达调控模式可能因物种不同而存在一定的差异。

It generally are anchored to the sea bottom or to a solid structure by rootlike holdfasts that perform the sole function of attachment and do not extract nutrient s as do the roots of higher plants.

通常以根状固着器固着于海底或某种固体结构上,固着器只起固着功能,而不像其它高等植物的根那样要吸收养分。

It generally are anchored to the sea bottom or to a solid structure by rootlike holdfasts that perform the sole function of attachment and do not extract nutrients as do the roots of higher plants.

通常以根状固着器固着于海底或某种固体结构上,固着器只起固着功能,而不像其它高等植物的根那样要吸收养分。

The need to evaluate the significance of stenotic lesions on heart function is why two exams are generally needed to perform a complete cardiac workup .

在心功能上需要评价狭窄性病变的显著性,为什么一般需要做心脏完整的两种检查。

It resembles the calculator being used in our daily life,can perform the function: plus, minus,multiply ,divide,serial addition and serial substraction, also can display the computing results correctly!

它类似日常生活中所用的计算器,可实现加,减,乘,除以及连加和连减等功能,并且能正确显示计算结果。

They perform not only environmental factors for tectonic activity , but also an important active power they are the transferential carrier of matter and energy , in fact , they also function as the material body of many energy resources and mineral solutions .

这些流体夹杂在地壳之中,既是各种构造活动的环境因素,也是一种活跃的动力因子;既是物质和能量转移和传递的载体,也是多种能源和矿液的实体。

These difficulties have ranged from the need to perform additional manual work flow steps to "temporarily work around" the problems to major delays in our ability to use the equipment and major additional unbudgeted expenses to attempt to provide the promised full functionality of the system.These idiosyncratic interfaces also add to the complexity of the system,which has resulted in increased equipment down time especially when software upgrades are installed on our modalities or information systems,which need to be further modified to continue to function properly.

这些困难都需要由人工进行额外工作流程步骤&暂时围绕&问题的重大延误,我们有能力使用的装备和重大预算外开支额外提供允诺全力试图对系统功能奇特的界面也增加了系统的复杂性,导致增加了设备安装的时间,特别是对我们的软件升级模式或信息系统,需要进一步改进,继续发挥作用。

Uses the automated control not only on the galvanization production line to be possible to raise the product manufacturing efficiency and to reduce worker's labor intensity, and has the very good economic efficiency and the social efficiency, galvanizes on the production line to be possible to realize the automated control using PLC, PLC has the reliability to be high, the compatibility is broad, has the correspondence function, the structure modulation characteristic, therefore how to use good PLC to become the galvanization production line automation control key, auxiliary to galvanized the automatic production line driving with PLC by the frequency changer to carry on the automatic control, had the structure to be simple, the programming was convenient, the operation was flexible, the use safe, worked stable, the perform reliably and the antijamming ability strong characteristic, was one kind of very effective automatic controlThe way, is galvanizes the production to realize, the low cost, the high grade automated production development direction highly effective.

在电镀生产线上采用自动化控制不但可以提高产品生产效率和减轻工人的劳动强度,而且有着非常好的经济效益和社会效益,电镀生产线上运用PLC则可以实现自动化控制,PLC具有可靠性高,适应性广,具有通信功能,结构模块化的特点,因此如何使用好PLC成了电镀生产线自动化控制的关键,用PLC辅以变频器对电镀自动生产线行车进行自动控制,具有结构简单、编程方便、操作灵活、使用安全、工作稳定、性能可靠和抗干扰能力强的特点,是一种很有效的自动控制方式,是电镀生产实现高效、低成本、高质量自动化生产的发展方向。

LiNbO3 crystals with linear electro-optic effect are utilized to perform the beam nutating function.

具有线性电光效应的LiNbO3晶体完成光束章动功能。

He can therefore perform the function of reinterpreting what the ego makes, not by destruction but by understanding.

因此,祂能重新诠释小我的妄作,不是消灭它,而是去了解它。

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Finally, according to market conditions and market products this article paper analyzes the trends in the development of camera technology, and designs a color night vision camera.

最后根据市场情况和市面上产品的情况分析了摄像机技术的发展趋势,并设计了一款彩色夜视摄像机。

Only person height weeds and the fierce looks stone idles were there.

只有半人深的荒草和龇牙咧嘴的神像。

This dramatic range, steeper than the Himalayas, is the upturned rim of the eastern edge of Tibet, a plateau that has risen to 5 km in response to the slow but un stoppable collision of India with Asia that began about 55 million years ago and which continues unabated today.

这一引人注目的地域范围,比喜马拉雅山更加陡峭,是处于西藏东部边缘的朝上翻的边框地带。响应启始于约5500万年前的、缓慢的但却不可阻挡的印度与亚洲地壳板块碰撞,高原已上升至五千米,这种碰撞持续至今,毫无衰退。