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Results:(1) The mean BMI of patients except for women aged from 20 to 29 years, was much higher than that of the general population (P.01).(2) The overweight (BMI≥24) ratio of the patients was much higher than that of the general population (P.01).(3) Patients with hypernormal BMI were more than those with normal BMI (BMI4) except for patients aged from 20 to 29 years.(4) Patients with hypernormal BMI were significantly more than those with normal body weight in all other occupations except for young students.

结果:①除了女性20岁~29岁年龄段外,其余各组患者体重指数的均数均明显大于中国普通人群体重指数的均数(P均<0.01);②本组患者中男、女性体重指数超常者(BMI≥24)所占的比重,均明显大于中国普通人群中体重指数超常者所占的比重(P均<0.01);③除了男、女20岁~29岁年龄段以外,其余各年龄段的患者中体重指数超常者所占的比重,明显大于体重指数正常者(BMI4)所占的比重;④除青年学生外,其他职业中体重指数超常者所占的比重,明显超过体重指数正常者所占的比重。

Results showed that rapid cycling patients were more likely to be female, a fact more evident in bipolar I than bipolar II patients. Rapid cycling patients also showed a younger age of onset and a higher occurrence of depression at study entry. In the year prior to the study, the rapid cycling group showed poorer global functioning and a significantly greater rate of depressive and hypomanic/manic episodes. History of psychosis showed no correlation with rapid cycling but bipolar I patients were more likely to have symptoms of psychosis than bipolar II patients.

研究结果显示,快速循环病患以女性较多,而在两极I及两极II病患中更明显,快速循环病患发病年龄较轻,在研究期间较常出现忧郁症状,研究之前一年,快速循环组显示较低的整体功能,且有明显较高比例的忧郁及轻躁症/狂躁症,但是精神病史显示这与快速循环没有关系,但两极I比两极II病患更容易出现精神病症状。

Results 107 patients were treated with half gland and isthmic portion excision, 43 patients among which were treated with lymph node dissection ;306 patients were treated with half gland and isthmic portion and majority opposite side excision,163 patients among which were treated with lymph node dissection ;and both side of thyroid was removed with half lymph node dissection in 46 patients; 1, 3 and 5 years surviving rate of thyroid carcinoma after operation were 99.0%, 96.5% and 92.6%.

结果 单侧腺叶,峡部切除64例;单侧腺叶,峡部加同侧颈淋巴结清除术43例;单侧腺叶,峡部,对侧腺叶次全切143例;单侧腺叶,峡部,对侧腺叶次全切加同侧颈淋巴结清除术163例;双侧甲状腺全切术加一侧颈淋巴结清扫术46例;局部姑息性切除术28例。

Retrospectivly analyse the coronary heart disease, 68 patients diagnosed the coronary angiography, including Unstable Angina the 24 patients, Stable Angina 32 patients, myocardial infarction 12 patients; Compares the change of normal comparison group 35 patients fasting blood lipide:Trighycerides, Total Cholesterol, High Density Lipoprotein Cholesterol, Low Density Lipoprotein Cholesterol, Apolipoproteins (ApoA1 and ApoB), Fasting Blood Glucose, Fasting Insulin, Insulin area under curve and Glucose area under curve.

回顾性分析经冠状动脉造影确诊的冠心病患者68例,其中包括不稳定型心绞痛患者24例,稳定型心绞痛32例,心肌梗塞12例;正常对照组35例的空腹血脂(血清甘油三酯TG、血总胆固醇TC、高密度脂蛋白胆固醇HDL-C、低密度脂蛋白胆固醇LDL-C、载脂蛋白ApoA1及ApoB)、空腹血糖、空腹胰岛素、糖负荷后胰岛素曲线下面积及葡萄糖曲线下面积的变化并进行比较。

The central theme of this thesis is to investigate the expression of lymphocyte surface marker and concentration of serum cytokines in four groups of patients with sepsis : Group 1, patients with Gram positive bacterial infection; Group 2, patients with Gram negative bacterial infection; Group 3, patients with negative cultures but strong evidence of infection; Group 4, patients without clinical and microbiologic evidence of infection as control group.

本研究主要以临床诊断为主再配合血液培养将病人分为四组:第一组是有革兰氏阳性细菌感染的病人;第二组是有革兰氏阴性细菌感染的病人;第三组是没有培养出细菌的感染性病人;第四组是由临床诊断及微生物培养证实为正常对照组。利用单株抗体接上萤光物质再配合流式细胞分析仪来测定淋巴球上各种细胞膜表面分化抗原的变化及利用酵素免疫分析法来探讨血清各种细胞素之变化。

In the article, we took part sample out of 158 patients to exam the expression level of Bcl-2 and Fas in myasthenic thymus tissue, and to find the role of which in whole pathogenesis. we also try to find the role of neopterin and sIL-2R through examing the concentration of neopterin and sIL-2R in peripheral blood of 26 MG patients. Material and methods1.select of case: to choose 158 patients who wear followed up from 1988 to 2002 after operation. All patients were diagnosed as MG, and treated with same medical cure during period of preoperation and post operation. 2.Collectionofdata:.To collect all data through designing a uniform follow-up table for thymectomized patients ,and to analysis the effect of factors including age, gender, disease duration of preoperation, clinic types and pathological types to prognosis at three follow-up period?

本文拟在对全组病例的远期预后进行流行病学统计分析的基础上,通过抽取一定量样本,研究重症肌无力患者胸腺组织中伽 12、Fas的异常表达及生发中心的形成在重症肌无力发病机制中可能的作用,以及它们对胸腺切除术后远期预后的影响;与之相似,通过检测部分样本外周血清中新碟吟和可溶性IL-2受体的浓度及其与正常对照组的差异,以期推测两者在重症肌无力起病及病情进展中的作用和意义,并分析其对胸腺切除术后远期预后的影响。

Objective To study the mechanism in which the personality, copying style influenced survival time by changing immunity function in the patients with gastric cancer Methods The Minnesota Multiphase Personality Inventory, coping style questionnaires and immunity function were measured in patients with gastric cancer on late stage, gastric cancer patients with longer survival time, and normal control Results Psychopathic deviate, social introversion subscale scores of MMPI in groupⅡ were significantly lower than that in the other two groups ( P 05) Statistical difference were found between groupⅠand groupⅡ in problem saving factor and help seeking factor of CSQ ( P 05) Natural killer cell level in groupⅡ was significantly higher than in groupⅠ( P 05) There was negative correlation between the NKC and depression, psychopathic deviate, paranoia, psychasthenia, schizophrenia subscale scores of MMPI, there was positive correlation between NKC and SP, coping type in patients with gastric cancer Conclusion The gastric cancer patients with longer survival time are more extroversive and have more mature coping styles Their NKC level is relatively higher The results may be advantageous to improve the prognosis of gastric cancer

作者中文名:王健;邹义壮;唐丽丽;李杰;张东;金山;刘娟摘要:目的研究胃癌患者的生存期与个性特征、应付方式等心理因素,以及免疫功能的关系。方法对胃癌晚期患者、胃癌较长生存期患者及正常健康人分别进行明尼苏达多相个性测验、应对方式问卷、免疫功能测试,并做相关分析。结果(1)MMPI:胃癌Ⅱ组人格障碍评分(42.0±10.5)及社会内向评分(42.2±11.6),低于其他两组[胃癌Ⅰ组为(49.3±11.2)分和(48.3±9.4)分,对照组为(48.6±10.9)分和(39.9±11.5)分;P均<0.05];(2)CSQ:解决问题和求助因子分,胃癌Ⅰ组[分别为(0.68±0.27)分和(0.42±0.18)分]均低于胃癌Ⅱ组[分别为(0.82±0.18)分和(0.65±0.21)分;P<0.05和P<0.01],胃癌Ⅱ组更多采取成熟的应对方式;(3)自然杀伤细胞:胃癌Ⅱ组水平(21.4±9.2)高于胃癌Ⅰ组[(14.2±8.8);P<0.05];而NK细胞水平与MMPI的抑郁(r=-0.35)、人格障碍(r=-0.39)、偏执(r=-0.29)、精神衰弱(r=-0.30)及精神分裂(r=-0.30)等量表呈负相关,与CSQ的解决问题因子(r=0.35)及应付方式类型(r=0.34)呈正相关。结论与胃癌Ⅰ组比较,胃癌Ⅱ组更为外向,负性情绪较少,更多采取成熟的应对方式,其NK细胞水平较高,对胃癌的预后产生了积极的影响。

Objetive:To investigate the histopathological features and detect the mutation of JAK2V617F in PV、ET and IMF;to analyze the effects of the stages of myelofibrosis and the mutation on the number of leucocyte in PV and ET patients;Methods: the morphological features of 69 patients who dignosed in the first time were studied by HGF and Gomori stains ; the mutation of JAK2V617F was detected in 38 blood or marrow samples of PV、ET and IMF patients by real-time PCR;the effects of the stages of myelofibrosis and the mutation on leucocytes were analyzed;Results: Different stages of reticulin were observed in 15 PV and 15 ET patiens'marrow sections,and the cytosis、the pleomorphism and the bone trabecula side location of megakaryocytes were observed in all PV、ET and IMF patients;the means of leucocyte in patients with and without JAK2V617F were 20.4×109/Land 11.4×109/L respectively;the P value was 0.367 as comparing the leucocytes among different stages of reticulin increasing.

目的:探讨PV、ET、IMF患者的骨髓病理特点并且检测JAK2V617F突变的发生率,分析骨髓中纤维增生程度以及JAK2V617F对PV、ET患者白细胞数的影响;方法:69例初诊患者的骨髓切片经HGF染色以及Gomori染色后进行形态学研究;并利用real-time PCR法测38例患者的骨髓或者外周血的JAK2V617F突变;分析骨髓切片中纤维组织增生程度以及JAK2突变对患者白细胞数的影响;结果:15例PV和15例ET患者的骨髓切片中可以观察到不同程度的纤维组织增生,所有PV、ET、IMF患者骨髓病理中可见到巨核细胞增多、巨核细胞多形性改变以及巨核细胞定位于骨小梁旁;12例PV、4例ET、4例IMF中检测到JAK2V617F;有突变和无突变患者发病时白细胞数均值分别为20.4×109/L和11.4×109/L,比较不同纤维增生程度的PV、ET患者的白细胞数均值,P值为0.367。

Methods : From March 2007 ~ January 2009, on the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine and the Fujian Provincial People's Hospital Medical digestion hospital outpatient , hospital and Digestive Endoscopy Center of Fujian Province with typical heartburn and reflux symptoms ( such as retrosternal pain , sour regurgitation or regurgitation ) in patients with gastroscopy Electronics , rule out the possibility that esophageal mucosal damage or performance , such as Barrett esophagus in patients with selected non-erosive gastroesophageal reflux disease patients , the study investigate with reflux disease questionnaire ( reflux diagnostic questionnaire , RDQ table ) to their symptom severity score , the application of internationally used self-rating anxiety scale ( Self-rating anxiety scale , SAS ), self-rating depression Scale ( Self-rating depression scale , SDS ) for all selected patients with anxiety and / or psychological evaluation of depression and total score statistics , observation of non-erosive gastro-oesophageal reflux patients and the relevance of Psychological factors.

自2007年3月~2009年1月,对就诊于福建省第二人民医院和福建省立医院消化内科门诊、住院和福建省消化内镜中心具有典型的烧心感和反流症状(如胸骨后疼痛、反酸或反食)患者行电子胃镜检查,排除有食管黏膜损害或Barrett食管等表现的患者,筛选出非糜烂性胃食管反流病患者,行反流性疾病问卷(reflux diagnostic questionnaire,RDQ表)对其症状评分,应用国际通用的焦虑自评量表(Self-rating anxiety scale,SAS)、抑郁自评量表(Self-rating depression scale,SDS)对所有入选患者进行焦虑和/或抑郁状态心理测评,并统计总积分,观察非糜烂性胃食管反流病患者症状积分与心理因素的相关性。

Methods fifty patients with chronic sinusitis or rhinopolypus who had undergone endoscopic sinus surgery are random divided into control group and controlled hypotension group, each 25 patients. All patients are ASAⅠ-Ⅱ.Patients in B group were under endotracheal anesthesia with1.5—2% isoflurane and sodium nitroferricyanide 1ug/ with infusion pump to controlled hypotension. Patients in A group were under operation with local anesthesia.

将Ⅱ型Ⅱ期—Ⅲ期慢性鼻窦炎、鼻息肉病人50例随机分为对照组和全麻控制性降压组,每组25例,两组病人均为ASAⅠ—Ⅱ级,控制性降压组采用气管内插管全麻下以硝普钠1ug/微量泵泵入及1.5—2%异氟醚持续吸入控制性降压,对照组采用局麻下手术。

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