查询词典 pathway

As a sequence, the cell evolved an adaptively coordinated response to limit further accumulation of unfolded proteins by expressing large amount of chaperons. In this pathway, Ite1, an ER transmembrane protein kinase/endoribonuclease, is essential for viability during ER stress.

当内质网腔内未折叠蛋白增多时，通过Irelp胞质面部分的丝氨酸／苏氨酸自磷酸化，诱导UPR特异性转录因子Haclp mRNA剪接成熟。

At present, the clinical application of immune tolerance induced by the program include: the establishment of mixed chimerism; application of costimulatory pathway blocking antibodies; removal of T-cell.

目前，在临床上应用的诱导免疫耐受的方案主要有：建立混合嵌合体；应用阻断共刺激通路的抗体；删除T细胞[1]。

To explore the reciprocal effects of host-tumor interaction, we developed a system to assess the gene expression patterns and the diversity of gene expression of ERK and PI3K pathway in CAOV3 human ovarian cancer cells and primary carcinoma-associated fibroblasts cocultured with each other for 48 hours with RT-PCR.

方法1。采用逆转录聚合酶链反应的方法分别检测交互作用48小时后的卵巢癌相关成纤维细胞与卵巢癌细胞中基因表达的改变，CAFs及CAOV3细胞外信号调节激酶通路的ERK，PI3K基因表达的变化；2。

Curcumine ramification has a good effect on the proliferation of K562, even better than curcumine, and might have the multiple inhibitory effect on the p210 initiated signal pathway.

姜黄素衍生物FM17较姜黄素有更强的抗增殖能力，对P210及其激活的信号途径也有较强的抑制作用。

Methods MTT assay was used to detect the inhibition of the proliferation of K562 cell in different time and different dose. The effect of curcumine ramification with different dose in different time on P210(superscript bcr/abl) initiated signal pathway was detected by western blotting analysis.

四甲基偶氮唑蓝法检测姜黄素衍生物不同时间点和不同的浓度对K562细胞增殖的抑制作用。western blot的方法分析姜黄素衍生物FM17不同浓度、不同时间点对P210激活的信号的影响。

Changes of key enzyme activities and metabolite contents in pathway of energy metabolism in Cysticerci cellulosae in vitro and in vivo were tested with albendazole and oxfendazole respectively.

测定体外培养的和猪体内的囊尾蚴于阿苯哒唑和奥芬哒唑分别作用后能量代谢途径物质含量及其关键酶活性变化。

METHODS: Firstly,depanding on the methods of FCM,MTT etc,we got the best density and actiontime of adriamycin.and then,we used several depressors of different signal transduction pathways to observe the possible pathway of osteosarcoma cell apoptosis.

首先通过FCM，MTT等方法探讨引起成骨肉瘤细胞凋亡的最佳药物作用浓度及时间；在此条件下应用不同信号转导通路的抑制剂观察导致细胞凋亡的可能通路；最后应用Western？？？？

Methods: firstly,depanding on the methods of fcm,mtt etc,we got the best density and actiontime of adriamycin.and then,we used several depressors of different signal transduction pathways to observe the possible pathway of osteosarcoma cell apoptosis.finally, we observed different expression including phosphorylation and non phosphorylation of correlated signal molecules,by the methods of westernblot.

首先通过fcm，mtt等方法探讨引起成骨肉瘤细胞凋亡的最佳药物作用浓度及时间；在此条件下应用不同信号转导通路的抑制剂观察导致细胞凋亡的可能通路；最后应用western blotting来检测在成骨肉瘤细胞凋亡过程中相关信号分子的表达水平及磷酸化水平的变化。

After binding with ligands, the RTKs would dimerize, simultaneously autophosphorylated and activated and then trigger the downstream signaling pathway.

大量工作表明，配体与受体结合，引起受体的二聚化并同时激活受体后，受体可结合大量的信号蛋白分子，如接头蛋白、入坞蛋白或各种调节蛋白等。

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

中文摘要缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。