查询词典 pathway

METHODS: We searched for abnormalities of the proapoptotic Bcl-x deamidation pathway in primary cells from patients with chronic myeloid leukemia or polycythemia vera, myeloproliferative disorders associated with the BCR-ABL fusion kinase and the Janus tyrosine kinase 2 (JAK2) V617F mutation, respectively.

我们分别对来自慢性粒细胞白血病或真性红细胞增多症、骨髓增生性疾病相关的BCR-ABL融合蛋白激酶及Janus酪氨酸激酶2 (JAK2) V617F突变体患者原代细胞凋亡前Bcl-x脱酰胺途径的异常情况进行研究。

BBR can activate extracellular-signal regulated kinase signaling pathway in liver cells very rapidly and dose dependently in vitro.

BBR在体外能迅速激活细胞的胞外信号调节激酶信号转导途径，ERK的激活作用在时间上提前于LDLR的表达增加。

DBP and DEHP have the similar photodegradation mechanism. The predominant pathway for DBP and DEHP photodegradation in the Fe -oxalate complexes system is hydroxyl radical extracting H atom in α-position of the aliphatic chain close to the carboxyl group followed by oxidation to produce alcoholized derivatives ROH. ROH then breaks down to phthalic acid and dialcohol that will be further oxidized up to mineralization.

DBP和DEHP的光降解历程相似，主要反应途径是OH自由基提取烷基上与羧基相连的α-H原子，然后被氧化生成醇衍生物，再分解成为酞酸和二醇，酞酸经历开环和进一步脱羧，二醇可以被氧化成为低级烷基羧酸，直至矿化。

At the mesencephalic, diencephalic, and pontine levels, thrombosis of small veins might be accompanied by a very large, sometimes hemorrhagic lesion, since there is nearly no collateral venous pathway.

但在间脑、中脑、脑桥水平，由于几乎没有静脉侧支循环通路存在，因此一旦这些部位的小静脉受累形成血栓，就会产生较大的、甚至有时伴出血的病灶。

The possible unfolding pathway of the dimeric TIM was discussed.

在低浓度盐酸胍存在下，TIM的热稳定性降低。

We found that the release of ROS in rat astrocytes was significantly increased by the stimulation of calcium ionophore or opsonized zymosan, which are known to trigger respiration burst in phagocytes by NADPH oxidase pathway. Further study indicated that diphenylene iodonium or apocynin , two inhibitors of NADPH oxidase, significantly suppressed ROS release caused by calcium ionophore or opsonized zvmosan.

我们发现在用吞噬细胞呼吸爆发刺激剂钙离子载体或酵母多糖刺激星形神经胶质细胞时，细胞O〓和H〓O〓产量均明显增加，而NADPH氧化酶的抑制剂二联苯碘(diphenylene iodonium，DPI)或夹竹桃麻素(apocynin，APO)均可以明显地降低刺激剂引起的细胞O〓和H〓O〓产量增加。

Were I to refer to the destiny of dipus, Joan of Arc, Agamemnon, you would give not a thought to their lives, but only behold the last moments of all, the pathway of death.

我提到俄狄浦斯、圣女贞德、阿甘门努，你一点都不会想他们活着时候的生活，而只会想到他们生命的最后那段走在通往死亡路径的那段日子。

We propose a pathway for how VKOR uses electrons from cysteines of newly synthesized proteins to reduce a quinone, a mechanism confirmed by in vitro reconstitution of vitamin K-dependent disulphide bridge formation.

这项工作可帮助解释VKOR 发生的突变何以能够引起对&华法令&的抵抗力，后者是通过抑制VKOR发挥作用的普遍使用的抗凝血剂。

Besides, the downstream of GGPP metabolism in diterpene metabolic pathway is now still unknow.

GenBank蛋白数据库中仅见有15条丹参蛋白质序列，在这些报道的蛋白中，与丹参酮类成分代谢途径相关的酶蛋白就更少，此外，丹参酮类成分次生代谢在GGPP以下的下游代谢途径目前还未知。

According to the classical signal transduction pathway of estrogen, we use Luciferase reporter gene to screen phytoestrogen form Selaginella tamariscina, Pinus massoniana Lamb, Corallodiscus flabellate, Dryopteris sublaeta Ching et Hsu and Leonurus heterophyllus. In this study,the pβgal-Control vector, the pERE-TAL-luc vector, the pCNX2-hERα/pCNX2-hERβvector were transfected into HEK293 cell line. If the components in the herbs combine with the ER, then it could induce the expression of reporter gene controlled by ERE.

根据体内的雌激素信号转导途径，我们选用了以luc为报告基因、ERE为调控序列的重组报告基因载体pERE-TAL-luc，并将其与重组人ERα(humanERα，hERα)表达载体pCXN2-hERα和重组人ERβ(humanERβ，hERβ)表达载体pCXN2-hERβ共转染ER阴性细胞系，建立了靶向ERα或ERβ的细胞水平药物筛选模型，结合小鼠子宫增重实验，对卷柏、松针、益母草、石胆草及贯众等5种中药的植物雌激素作用进行了研究，以期为临床防治更年期综合症等提供准确、科学的实验基础。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。