查询词典 pathway

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

During this period, the Roman baths, the dockyards of the port of Alkinoos and an important part of the stone pathway in the ancient market.

在此期间，发掘出了罗马澡堂、阿尔客诺俄斯港的码头和古集市路面上的重要的铺路石。

When I had spent enough time petting the dows, I would walk up the little cobblestone pathway to Mr. Nimo's door and just walk in.

当我爱抚够牛之后，我会走上那条小小的鹅卵石路来到尼莫家门口，然后直接走进去。

The intracellular signal pathway and effectors activated by G protein were also investigated.

对G蛋白激活后的信号转导途径及其可能涉及的胞内信使进行了检测。

By the study of elicitors' action mode on Taxol biosynthesis, their action point in Taxol biosynthesis pathway an...

本文通过对诱导子促进紫杉醇合成的作用模式研究，推导诱导子在紫杉醇合成途径上的作用部位，确定其配伍特性。

The conflict between protection of wild animals and development rights of local farmers is prominence.Based on the conflict between farmers and wild boar,inquiry and informal discussion were adopted to study about the damage of emblements by wild boar.Lack of laws and regulations and Lack of compensation pathway were main reason.Correspondi...

针对保护区居民与野猪冲突日益严重的现状，采用调查、座谈访问的形式，研究太白山自然保护区野猪损害庄稼问题，主要原因表现在法律、法规的缺陷和补偿途径的缺失，从完善法律、修改补偿程序及手段等方面提出相应的解决对策。

This integration allows users of NCBI's Entrez databases to quickly categorize proteins, genes and small molecules by metabolic pathway, disease state or other BioSystem type, without requiring time-consuming inference of biological relationships from the literature or multiple experimental datasets.

这个整合允许NCBI的Entrez数据库的用户通过代谢通路，疾病状态或其他BioSystem类型快速的分类蛋白质，基因和小分子，不需要从文献或多个实验数据集中耗时的推论生物学关系。

ERF genes can express in biotic and abiotic stresses and it may play roles in the cross-talking of multi signal pathway.

ERF基因的表达受到疾病相关刺激以及环境胁迫的诱导，并且在乙烯、茉莉酸和水杨酸信号传导途径中发挥一定的作用。

Besides, the signal transduction pathway, including ERKs、JNKs and p38 involved in arsenic and its metabolites are totally different.

其中，砷化物可能透过的机转包括ERKs、 JNKs和p38三条路径，彼此间确实有明显的不同。

Mechanical strains also regulated the protein and mRNA expression of several differentiation markers, as well as the activation of extracellular signal-regulated kinases, p38 MAP kinase and protein kinase B in a frequency-dependent manner. Furthermore, the inhibition of p38 pathway could block the strain-frequency induced the phenotype modulation of VSMCs, neither ERKs nor Akt. Frequency of mechanical strain, not conditioned medium, regulated the phenotype of VSMCs in a frequency-dependent manner. Rho-GDI alpha was suppressed by the mechanical strain at 1Hz.

采用免疫细胞化学法检测VSMCs形态和排列的变化；RT-PCR和Western blotting检测表型标志分子α-肌动蛋白、肌球蛋白重链(SM1/2)、肌动蛋白相关蛋白SM22α和调宁蛋白(h1-calponin)的mRNA和蛋白水平的变化；抑制剂或RNA干扰阻断可能的信号调节分子的活性或表达，包括p38、细胞外信号调节激酶1/(2extracellular signal-regulated kinases， ERK1/2)、蛋白激酶B和Rho-鸟苷酸解离抑制因子(Rho-guanine nucleotide dissociation inhibitor， Rho-GDI alpha)，研究了不同频率张应变对VSMCs表型转化的影响及其调节机制。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。