查询词典 parameters

OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上，结合病人个体特征，以1，2个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案结论经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

The proposed method has the merit that the numerical characteristics of stochastic temperature field response can be obtained by analyzing the random temperature field just in one time.3. Perturbed numerical algorithm of nonprobabilistic convex set theoretical models on the temperature fieldThe uncertain parameters of physical parameters and initial boundary conditions of heat conduction are described by the convex model. The perturbation formulas of the upper and lower bounds of temperature field response with unknown-but-bounded parameters are given via the combination of matrix perturbation theory and the convex set theory model.4. Numerical analysis for transient temperature field with interval parametersConsidering the uncertainties of the transient heat transfer, the physical parameters and initial boundary conditions are regarded as interval variables.

该方法具有只进行一次随机温度场分析便可以获得其响应的数字特征的优点。3、温度场的非概率凸集合理论模型的摄动数值解法将结构导热的物理参数、温度场的初始和边界条件等不确定性参数以凸模型加以描述，基于矩阵摄动理论和处理不确定问题的凸集合理论模型的结合，导出有界不确定参数瞬态温度场响应所在集合的上、下界摄动计算公式。4、具有区间参数的瞬态温度场数值分析考虑结构瞬态热传导问题的不确定性，将结构各物理参数和温度的初、边值条件均视为区间变量。

Operational Parameters/Critical Parameters cont'd Operational Parameters: Operational parameter values are identified for those process parameters where substantial excursion from the specified range could reasonably be expected to reach or exceed a critical value that would detrimentally affect the quality of the resulting product.

操作参数/关键参数操作参数：在偏离规定范围，达到或超过临界数值从而对结果产品造成质量损害的情况下，要找出那些工艺参数的操作参数数值。

The methods of computing for similar coefficient were Discriminance of Minimal Difference of Parameters, Discriminance of Limen of Tree Compositive Character and Synthetic Weight Similarity of Parameters. The contribution of all parameters were considering as same for DMDP and DLTC, but it estimate s the similarity between parameters according to the limen for DLTC. DMDP was based on the principal component analysis for wood transverse section micrograph characters and computing the similar coefficient according to the contribution of every parameter.

其中最小差值差数判别法与树种综合特征阈值法是将每个特征参数对木材横切面显微图像特征的贡献率视为一致，只是树种综合特征阈值法是以阈值的大小来判断特征的相似性，而综合加权相似法是建立在对木材横切面显微图像特征参数的主成分分析的基础上，根据每个特征参数的贡献率大小计算相似系数。

Based on investigating the short and intermittent structural plane, surrounding rockmass of the huge underground powerhouse in Three Gorge has been divided into five statistical similar areas according to its characteristic of rockmass structure by applying structure plane network simulation. Distributed characteristic of structural plane has been studied and based on it mechanics macrocharacteristic has been studied:(1) It is the first time that based on the result of structural plane network simulation rockmass quality of every structure area has been studied with applying blurred information optimum seeking technique and be compared with and RQD method. The result indicated that it has better effect to evaluate rock quality with blurred information optimum seeking technique.(2) It is the first time that the interrelated relationship of the result of in-suit rockmass deformation test and fractal characteristic of structure on test point has been applied to determine rockmass deformation parameter. The question of evaluating deformation parameters of engineering rockmass has been solved.(3) Anisotropy strength parameters have been determined by applying shear zones simulating method. The result indicated that there are different strength parameters in every structural area, after comparing the result of Fast Lagranian Analysis in continua number simulation method with that of method of weighted mean according to continuity. The result indicated that when a suitable reduction coefficient is been considered rockmass strength parameters can be simply and fast determined with method of weighted mean according to continuity where there is not enough test result.(4) Damage characteristic has been studied based on analysis fractal characteristic of structural plane network by applying fractal-damage coupling method. It is the first time that the concept of damage degree has been set up to evaluate rockmass quality according to the biggest principal damage.

通过对短小、断续性结构面统计特征的研究，将地下厂房区划分为五个岩体结构统计均质区，应用结构面网络模拟技术研究了各个岩体结构均质区结构面的发育分布特征，并以此为基础对岩体宏观力学特性进行了深入研究：(1)首次通过在结构面网络模拟计算结果的基础上，应用模糊信息优化技术研究了厂房区各个岩体结构分区的岩体质量并与岩体基本质量指标研究法、岩体质量指标RQD值研究法作了对比，结果表明以结构面网络模拟结果为基础，应用模糊信息优化技术进行岩体质量评价能够取得很好的效果，解决了工程岩体质量的定量评价问题；(2)首次通过对已有的现场大型岩体变形试验结果的分析及相应试验点岩体结构分形特征的研究，建立了结构面分布的分形维数和岩体变形指标间的相关关系，并首次应用这种相关关系根据结构面网络模拟及分形维数计算结果确定了缺少试验结果的地下厂房各工程部位的岩体变形指标而且应用于围岩稳定性计算，解决了工程岩体宏观变形参数的评价问题；(3)应用在结构面模拟网络图上模拟岩体剪切破坏带的方法，得出了岩体在不同方向上的强度参数，结果表明岩体的强度特性与结构面的发育方向和程度有着明显的关系，各个岩体结构均质区具有不同的强度参数；同时还通过应用拉格朗日差分法对岩体强度指标的数值分析并与按连通率加权平均计算法对比表明，按连通率加权平均计算法在考虑合理的折减系数情况下，可以简单快速地对缺少现场大型试验结果的具体工程部位实现岩体强度指标的估计，通过以上研究解决了工程岩体抗剪强度参数的评价问题；(4)通过结构面网络分形维数的研究，应用分形损伤耦合分析方法，研究了厂房区岩体的损伤特征，并首次引入"损伤度"的概念，建立了应用最大主损伤评价岩体质量的指标体系。

This article that focuses on the systematic and in-depth research in the current primal problem about abnormal burst pressure reservoir depress burst pressure has procured following main fruits:1 It forms the method which could obtain massive vertical static state mechanics parameters.2 In a foundation of acquisition of rock mechanics parameters,apply bent lamella that as mechanical model along with characteristic of actual geologic characteristics to analysis curvature for anticlinal strcture, get homologous tectonic stress value throug relation between the curvature and stress and different principal curvature in anticlinal structure,consequently set up laminational stress model for anticline reservoir. The block lamination for existed fracturing date has formed method of setting up mechanical model of lamination terrestrial stress by abtaining the block tectonic stress coefficients which are got by complex utilization test, laboratory test and fracturing date playback.3 Analysesing the main reason which lead to high burst pressure by considering the characteristic of reservoir geology,reservoir,and rock mechanics and reservoir damage,etc.Establishing burst pressure quantitative prediction model which provide gist for depressing construction risk and optimizing construction craft under the condition of open hole completion ,gun-perforated completion and damaged reservoir.4 Provding theoretical basis for interpreting acidification pretreatment which could depress busrt pressure by finding the relation between the influencing factors and rock machanics parameters and analysing the factors that have effect on rock mechanics parameters. Expounding the mechanism of reaction of mixed monomineral and acid from the angle of microcosmic element, evaluating quantitatively acid sensilility of different kinds of mineral effectively, and determing the first-order reaction dynamical equation of each mineral.5 Revealing rock mechanics property chage as a result of acid flooding in different condition by sandstone traumata experiment in different temperatures which combined with rock mechanics triaxial stress experiment.6 Associating damage mechanics with sandstone acidizing, established sandstone damage mechanics model in the foundation of the recognition on the rock mechanics parametric variation which is caused by acid-rock reaction in both macroscopic view and microscopic view ,also demonstrated those processes and quantitative estimated the acid busrt pressure to direct the site operation.

本文针对目前异常破裂压力储层降低破裂压力的主要问题展开较为系统和深入的研究，取得了以下主要成果：1形成了利用测井资料，结合室内岩芯测试结果，获取静动岩石力学参数的相关性特征，从而获得纵向上大量静态力学参数的方法。2在获取了岩石力学参数的此基础上，利用弯曲薄板作为力学模型，结合区块实际地质特征对背斜构造进行曲率分析，通过曲率与应力的关系，利用背斜构造不同部位的主曲率求得相应的构造应力值，从而建立起背斜储层的分层应力模型；对已有压裂资料的区块分层，形成了综合利用测试、室内实验、压裂资料反演获得该区块构造应力系数，建立起分层地应力的力学模型的方法。3综合考虑储层地质、油藏、岩石力学特性和储层伤害等因素，分析造成高破裂压力的主要原因，综合利用岩石力学、弹性力学等知识，建立了裸眼完井、射孔完井条件下以及储层受到伤害后的储层破裂压力定量预测模型，为降低施工风险和优化施工工艺提供了依据。4完成了物性、岩性影响岩石力学参数的因素分析，找出了各影响因素和岩石力学参数之间的关系，为从机理上解释酸化预处理降低破裂压力提供了理论基础；从微观元素的角度阐述了单矿物与酸反应的机理；并在此基础上，有效评价了各种矿物的酸敏感性，定量确定了岩石中各矿物的一级反应动力学方程。5完成了不同温度下的酸液类型、酸液浓度、注酸量等一系列砂岩损伤实验，结合岩石力学三轴应力实验，系统揭示了在不同条件下注酸而引起的岩石力学性质变化。6将损伤力学与砂岩酸化相结合，在宏观、微观两个方面认识酸岩反应引起岩石力学参数变化基础上，建立了砂岩损伤力学模型，并对其进行验证，在此基础上定量计算酸化后的破裂压力，有效指导现场施工

A water model for simulation of 1050 mm mold is established to investigate the effects of SEN structure, casting speed, immersion depth and other parameters on the fluctuation of the liquid level in the mold, the impact depth of the steel stream and entrapping of the flux, and compare the influence of different structure parameters and operating parameters on the flowing field in the mold in order to find out the best suitable compromise between the structure parameters and the operating parameters and then...

针对 10 5 0mm× 15 0mm断面的结晶器，建立了水模型，研究浸入式水口结构、拉速、浸入深度等工艺操作参数对结晶器液面波动、流股冲击深度及结晶器钢液面保护渣卷入情况的影响，比较不同水口结构参数及操做参数对结晶器内流场的影响，从而找出结构参数与工艺参数间配合最佳的工况，为水口设计提供理论依据，并经优化的水口在实际中应用，使安钢第二炼钢厂的板坯退废率由 1.5 0 %降为0 。6 %。

On the basis of the theory of stretch distortion,according to the reality facts,with the geometrical figuration method,this paper affords the mathematical modules about the structural parameters,the dynamic parameters,the positional parameters,the mechanical parameters and the technical parameters of coil box,and programs a design software system .

本文在弹塑性弯曲变形理论的基础上，从实际情况入手，借助几何成形的方法，提出了计算热卷箱结构参数、运动参数、位置参数、力能参数和工艺参数的数学模型，并在此基础上编制了一套完整的热卷箱设计的计算机软件系统。

Spline Broach complexity of the design process, the geometric parameters, many of which need to look-up table and complex calculation to determine the parameters of a certain size, Design Spline Broach all forms and formulas into C language are procedures, through a simple C program calls, importation Spline Broach the technical parameters can be accurately its design parameters, Finally, all the parameters of integrated print out data tables, thus simplifying the complex Spline Broach design process, and meet the design requirements.

花键拉刀设计过程复杂，几何参数多，许多都需要查表和复杂的计算来确定某一参数尺寸，把花键拉刀设计中所有表格和计算公式都编成C语言程序，通过简单的C程序调用，输入花键拉刀的技术参数就可以准确得到其设计参数，最后把所有的参数值综合打印出数据表格，从而简化了复杂的花键拉刀设计过程，且达到了设计的要求。

Spline Broach complexity of the design process, the geometric parameters, many of which need to look-up table and complex calculation to determine the parameters of a certain size, Design Spline Broach all forms and formulas into C language are procedures, through a simple C program calls, importation Spline Broach the technical parameters can be accurately its design parameters, Finally, all the parameters of integrated print out data tables, thus simplifying the complex Spline Broach design process, and meet the design requirements.

花键拉刀设计过程复杂，几何参数多，许多都需要查表和复杂的计算来确定某1参数尺寸，把花键拉刀设计中所有表格和计算公式都编成C语言程序，通过简单的C程序调用，输入花键拉刀的技术参数就可以准确得到其设计参数，最后把所有的参数值综合打印出数据表格，从而简化了复杂的花键拉刀设计过程，且达到了设计的要求。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。