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Abnormal endomertrial microenvironment is responsible for menorrhagia of patients with uterine leiomyomas. tPA and PAI as plasma fibrinolysis factors play an important role.

子宫内膜内环境异常是子宫肌瘤患者产生月经过多的原因之一,tPA/PAI作为纤溶活性因子发挥着重要作用。

Thrombi n could enhance mesangial cell proliferation, and up-regulate protein activity and mRNA expression of PAI-1 in cultured human embryonic glomerular mesangial c ells.

凝血酶可通过促进系膜细胞增殖、PAI-1的表达和提高其活性而导致肾脏损伤。

At pre-operation, post-operation 6 h, 3 d and 7 d detect the leave of plasm prethrombotic state molecular marker tissue factor, tissue factor pass inhibitory, thrombus precursor protein, plasminogen activator inhibitory-1(PAI-1), P-Selectin, Thrombin-Antithrombin complexes, D-dimer with ELISA, transmission immunity nephelometer. Results Malignant tumor patients, the levels of plasma TF, TpP, D-D in 6 h and 3 d of post-operation rose to peak value.

分别于术前、术后6 h3、d和7 d用ELISA、透射免疫比浊法检测其血浆血栓前状态分子标志物D-二聚体(D-dimer, D-D)、血栓前体蛋白(thrombus precursor protein, TpP)、凝血酶抗凝血酶复合物(thrombin-antithrombin complexes, TAT)、组织因子(tissue factor, TF)、P选择素(P-Selectin, P-S)、组织因子途径抑制物(tissue factor pass inhibitory, TFPI)、纤溶酶原激活物抑制物1(plasminogen activator inhibitory-1, PAI-1)的水平。

It was considered an effective and ideal model of PM.2 uPA,PAI-1 and TNF-αwere all involved in the pathogenesis of PM and participated in the process of the degeneration,apoptosis and necrosis of the diseased muscle.3 MMP-9 and TIMP-2 immunoreactivity were positive in the capillary,venous wall,arteriola endotheliocyte and neurilemma in the normal group skeletal muscle,but more intensive in EAM.They may aggravate the pathological changes of the muscle in human PM.

结论1兔纯化的肌球蛋白加含卡介苗的完全弗氏佐剂可仿制出人类多发性肌炎的理想动物模型。2 UPA、PAI-1和TNF-α参与多发性肌炎的肌纤维坏变过程。3 MMP-9和TIMP-2在正常肌肉组织中的毛细血管、静脉管壁、动脉肉皮细胞和神经鞘膜表达,在多发性肌炎中,参与加重肌纤维的坏变过程。

Methods The cognitive impairment rat model was induced by hypodermic D-galactose injection and half fat feeder (6 weeks), the Morris water maze was used to screen the model rats, which were divided randomly into 4 groups (12 rats in each group): the model group, the hydrochloricdonepezil group (0.4 mg/kg, weight, sic passim), the low-dose Huannao Yicong Fang group (7 g crude drug/kg), the high-dose Huannao Yicong Fang group (14 g crude drug/kg), they were treated respectively by intragastric administration. Besides, a control group of 12 rats was set up, they were given tales doses of distilled water. After 4 weeks, the behavior of the rats was detected, the contents of plasma P-selectin and PAI-1 were measured by ELISA, also the hemorrheology was measured.

采用皮下注射D-半乳糖及喂饲半高脂饲料(6周)的方法造成大鼠认知功能障碍,Morris水迷宫行为学测试确定模型成功的动物,随机分成四组(每组12只:模型对照组给予等量水,盐酸多奈哌齐组(0.4mg/kg,体质量,下同),还脑益聪方低剂量组(7g生药/kg),还脑益聪方高剂量组(14g生药/kg),同时灌胃给药,并设立正常对照组,给予等量水。4周后,对大鼠行为学检测,应用酶联免疫法检测大鼠血浆P-选择素及PAI-1含量和血液流变学各项指标。

Electro-acupuncture could lower abnormally-increased plasma t-PA、PAI-1 amount, advance activity of rats blood fibrinolytic system, protect integrality of vascular endothelial cell, promote thromb elimination, relieve chronic angiospasm, improve collateral circulation, enhance recovery of ischemic and semidarkness region, consequently protect the brain tissue from injury.

电针能降低急性脑梗死大鼠血浆异常升高的t-PA及PAI-1含量,提高大鼠纤溶系统的活性,保护血管内皮细胞的完整性,促进机体清除血栓、缓解慢性血管痉挛、改善侧枝循环,促进缺血区及半暗带的恢复,从而发挥脑保护作用。

On the basis of foregoing computer-aided instructional software's demand, I open up PAI system.

根据以上对计算机辅助教学软件的要求,开发了PAI系统。

They also had a more adverse atherothrombotic profile, with higher tissue-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) antigen.

他们也具有更不利的动脉粥样化血栓形成的曲线:更高的组织纤溶酶原激活物和纤溶酶原激活物蛋白抑制剂1 (PAI-1)抗体。

Objectives To investigate the effect of fibrinogen on tissue-type plasminogen activator and plasminogen activator inhibitor-1(PAI-1) mRNA expression in human umbilical vein endothelial cells.

目的 探讨纤维蛋白原对内皮细胞组织型纤溶酶原激活物和纤溶酶原灭活剂(PAI-1 mRNA表达的影响。

In order to elucidate the regulation of proteolysis during spermatogenesis and maturation, expression of tissue-type PA and PAI-1 in testis and the accessory organs of rat has been investigated.

为探讨精子发生及成熟过程中蛋白水解酶调节机制,我们以大鼠为模型对组织型PA和PAI-1在睾丸及附性器官中的表达作了初步研究。

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