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Objective To investigate the effects of rapamycin on p-JAK2, STAT3, p-STAT3 and PCNA in ranal tissue of IgAN rats.

目的 探讨雷帕霉素对IgA肾病大鼠肾组织p-JAK2、STAT3、p-STAT3和PCNA表达的影响。

RESULTS: After 15 week treatment, the levels of total cholesterol and low density lipoprotein cholesterol in therapy group decreased remarkedly as compared with control group (P<0.01). The incidence of non lethal myocardial infarction, unstable angina pectoris, cardiac death, and vascular reaonstruction in therapy group also declined (P<0.05 vs control group).

结果: 立普妥治疗后,治疗组与对照组比较对降低总胆固醇和低密度脂蛋白胆固醇有显著性效果(P<0.01),且治疗组发生非致死性心肌梗死、不稳定型心绞痛、血管重建、冠心病死亡者较对照组减少,差异有统计学意义(P<0.05)。

RESULTS: After 15week treatment, the levels of total cholesterol and low density lipoprotein cholesterol in therapy group decreased remarkedly as compared with control group (P<0.01). The incidence of nonlethal myocardial infarction, unstable angina pectoris, cardiac death, and vascular reaonstruction in therapy group also declined (P<0.05 vs control group).

结果: 立普妥治疗后,治疗组与对照组比较对降低总胆固醇和低密度脂蛋白胆固醇有显著性效果(P<0.01),且治疗组发生非致死性心肌梗死、不稳定型心绞痛、血管重建、冠心病死亡者较对照组减少,差异有统计学意义(P<0.05)。

Results: The contents of MT in rats' lung tissues of resectional pineal gland group were prominently increased than those of control group (P.01). The contents of TEN-γ in rats' BALF of negative injury group and resectional pineal gland were significantly increased than those of control group (P.05), but the change of IL-6 was not significant.

结果:松果腺切除组大鼠肺组织MT较正常组显著升高(P.01),伪手术组和松果腺切除组大鼠BALF中IFN-γ含量均较正常组明显升高(P.05),IL-6变化则不甚明显。

The effects of ratio of formaldehyde to phenol r(subscript F/P, ratio of NaOH to phenol r(subscript NaOH/P and resinification temperature on chemical properties of liquefied wood resins were investigated.

考察不同甲醛与苯酚物质的量之比值r(下标 F/P、氢氧化钠与苯酚物质的量之比值r(下标 NaOH/P和树脂化温度对树脂理化性能的影响。

During open/close movement, the distance of condylar movement is smaller than normal occlusion(P.05). During protrusion/retrusion movement, protrusion extent increase,the distance of condylar movement is bigger than normal occlusion(P.05). During lateral excursion, the trace in sagittal plane of the non-working side condyle is more incline than protrusion movement trace and the distance of the left non-working side condylar movement is larger than the right. During mediotrusion/right movement, the left biggest space distance is larger than normal occlusion and the transversal condylar inclination is smallar than normal occlusion when the distance of condylar movement is 5mm, the difference is statistically significant.

在开闭口运动时,双侧髁突运动幅度减小、位移量小于正常牙合者(P.05);前伸后退运动时,前伸幅度增加,位移量大于正常牙合者(P.05);侧方运动时,非工作侧髁突在矢状面上的轨迹较前伸轨迹向前下方倾斜度增加,非工作侧髁突空间位移左侧大于右侧,向右侧方运动中,左侧髁突空间位移大于正常牙合者,髁突位移5mm时水平面髁突倾斜度小于正常牙合者,差异有统计学意义。

Finally, simulation software was developed with Visual C++ and Delphi for 2D molding analysis of MIM, which affords facilities for the quality forecast of 2D thin wall parts and optimal design of mold and process parameters. In the research of molding performance of MIM feedstock, for the shortcoming of capillary rheometry, it was propounded that using spiral mold test molding performance of feedstock, and a set of spiral mold was creatively designed with quickly exchange gates and closed mold cavity. With the spiral mold, an orthogonal experiment was made on getting regress equation of flow length L〓 of the heavy alloy feedstock. Then the rule of L〓 varying with Q〓, P〓, and ΔT〓 was discovered. Q〓 ranks first in the influence on process parameters of molding performance, P〓 and Δ T〓 second. Therefore the injection rate Q〓 should be controlled primarily to improve the flow performance of feedstock.

在MIM喂料注射成形性能研究方面,针对毛细管流变仪测试法衡量流动性能的不足,提出使用螺旋线模具测试喂料熔体的注射成形性能,创造性地设计了一套可快换浇口,模腔封闭的螺旋测试模,并在螺旋测试模上采用正交实验设计,得出了高密度重合金喂料流动长度L〓的回归公式,揭示了L〓随Q〓、P〓、△T〓和S〓的变化规律,并得出工艺参数对成形性能影响的强度顺序为Q〓最大,P〓与△T〓其次,因而改善喂料流动性能应优先控制注射速率Q〓。

Results: DS participants had a larger ROMPx (p.05) and a smaller ROMPy (p.05) than those in normal participants (Px: 0.06±0.02m, Py: 0.12±0.03m).

结果:唐氏症个案COP左右偏移范围较正常个案大(p.05),而COP前后偏移范围却较小(p.05)。

RESULTS: The respiratory control rate and P/O ratio decreased gradually as rectal temperature increased. When Tr rosed to >42℃, RCR and P/O ratio decreased by 31.4% and 11.05%( P <0.05) respectively.RCR decrease resulted mainly from the effect of respiratory state Ⅳ.

结果:热应激大鼠心肌线粒体呼吸控制率(respiratory control ratio, RCR)及氧化磷酸化效率均随动物直肠温度的升高逐步显著降低,当大鼠直肠温度超过42℃时,RCR与P/O分别较对照下降31.4%,11.05%。

The Results displayed: DChanges of histological morphology in treating group is superior to the other two groups.(2Expression of BMP-2 at fracture region in treating group is obviously supeior to the other two groups(p.05) and advancely reach peak valuce at first weak.(3) transcriptional level of BMP-2 mRNA in treating group is obviously supeior to the other two groups(p.05) and samely advancely reach peak valuce at first weak.(4)In every period of fracture healing, the expression of BMP-2 and transcriptional level of BMP-2 mRNA appear dynamic change and begin to go up after fracture, moreover reached to peak value in two weaks, then go down gradually.

结果发现:(1)治疗组组织形态学检查明显优于其它二组;(2)治疗组骨折部位骨形态发生蛋白-2(BMP-2)的表达水平比其它二组明显提高(P<0.05),并在一周时提前达到高峰;(3)治疗组骨折部位骨形态发生蛋白-2(BMP-2)mRNA的转录水平比其它二组明显提高(P<0.05),同样在一周时提前达到高峰;(4)在骨折愈合的不同时期,BMP-2的表达及其mRNA的转录水平呈动态变化,即骨折后开始升高,2周左右达到高峰,以后逐渐下降。

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P.R.E.N.U.P.
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