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Results: The mean UI in Chongqing district were higher than proper iodide standard defined by international Council for control of iodine deficiency disorders,and the UI in HT groups were significantly increased compared with Con(P.05). The thyrocele and ophthalmopathy in AITD became more and severer accompanying UI increasing, the rate of goiter and endocrine ophthalmopathy in high iodide AITD was significantly higher than PI AITD( P.05).In the meantime, the positive percentage of TGAb and TPOAb also increased evidently in HI compared with PI(P.05).Cytokine IL-1?

结果:三组患者的平均UI水平高于国际碘缺乏理事会规定的适碘范围,HT患者的UI水平较正常人显著升高(P.05);在AITD患者UI水平的升高伴随着甲状腺肿大、眼部并发症等临床症状的加重,高碘组与适碘组相比差异有显著性(P.05),且随着UI水平的提高,TGAb和TPOAb阳性百分率明显提高,不同UI水平各组间和每两组间有显著差异(P.05)。

Results: The activities of ALP and ACP, except ACP in the sixth month significantly decreased in the group of thyroidism comparing with that of the control group (P<0.01), but only the activities of ALP significantly decreased in groups of ovariectomy and diabetes (P<0.05, P<0.01), and there was close relationship between enzyme activities and histopathologic variations.

结果:甲状腺素组除6个月组ACP活性较高外,ALP与ACP活性均较对照组低,有统计学差异(P<0.01);糖尿病组和卵巢切除组仅ALP降低有统计学差异(P<0.05或P<0.01),酶的活性与骨形态结构变化相吻合。

Expression of β-catenin in metastatic carcinomas was significantly lower than that in primary colon carcinomas (p.01). expression of e-cadherin in metastatic carcinoma was significantly lower than that in primary colon carcinoma(p.01),especially in tubiform adenocarcinoma and well and moderately differentiated carcinoma.

结果] 原发灶及其淋巴结转移灶中β-结肠术后多久的正常表达率分别为23.46%和4.94%,原发灶中术后多久高于转移灶(p.01),尤其是高中分化病例,转移灶中异位表达率显著高于原发灶(45.68%比28.40%,p.01),尤其是管状腺癌;原发灶中β-cat表达强度显著高于转移灶(p.01)。e-cad的表达强度在原发灶显著高于转移灶(p.01),尤其是管状癌症治疗和高中分化病例。

ANP and CX43 began to express at 2nd week after induction and increased gradually,about 60% of the resulting myogenic cells were positive at 4th week after induction ,they were negative for uninduced cells.hMSCs'surface antigen profiles obtained by Flow Cytometry were negative for CD31\CD34\CD45 before and after induction,but CD90 expressed higher after induction while was weak positive before induction(P.05). Apotosis index was correlated with the cultural time after induction,The apoptosis rate of induced hMSCs was remarkably higher than control group(P.01),and the variation between groups was notable(P.05),the cell cycle analysis showed that the percentages of G_0/G_1phases were reduced significantly after induction. The expresstion levels ofβ-MHC and CTNT mRNA were undetectable before induction,began to increase at 1st、4th week after induction,reached the peak at 6th week and decreased after that,the expression of Bcl-2 and Bax mRNA varied regularly after treated with 5-azacytidine. hMSCs'resting membrane potential、range and rate of depolarization were heightened gradually after being induced.

结果:hMSCs诱导前为纺锤形,诱导后第2天部分细胞即开始发生形变,呈球形或短棒状,1周后胞浆中颗粒增多,约20~30%细胞边缘呈毛刷样变化;hMSCs表面抗原CD31、CD34、CD45在诱导前后差异无统计学意义,CD90未诱导时表达呈弱阳性,诱导后明显增高(P.05);ANP和CX43在诱导前无表达,诱导后第2周开始表达且表达随时间逐渐增强,但CX43在诱导后第5周表达量开始降低。hMSCs诱导后凋亡指数随诱导后培养时间增加,低浓度诱导组低于标准浓度诱导组,组间差异有统计学意义(P.05),G_0/G_1期细胞比例诱导后较对照组显著减少(P.05);β-MHC和CTNT基因分别在诱导后第1周和第4周时表达开始增强,在第6周时均达到高峰,第8周时表达开始衰减,Bcl-2、Bax基因表达呈时间依赖性变化,hMSCs经诱导后随心肌样细胞特征的表达膜静息电位、去极化幅值和去极化速率逐渐增高。

At last,a convergent and general protocol to marine natural product,as demonstrated by the enantioselective total synthesis of malyngamides O,P,Q,R, 5"-epi-Q and 5"-epi-R bearing terminal vinylic chloride structure,was developed in detail.E,(7S)-7-methoxytetradec-4-enoic acid was prepared using the above described Johnson-Clainsen rearrangement,the terminal vinyl chloride was constructed using Wittig reaction as key step,the pyrrolidone derivative was constructed using L-serine as natural chiral pool.Starting from the synthesis of malyngamides O and P to explore the general route,an aldol reaction of methyl acetate with the vinyl chloride part in the presence of LDA gave the skeleton of amine portion,followed by amidation with the fatty acid finished the synthesis of malyngamide P.

先以malyngamides O和P为试点探索通用合成路线,将乙酸甲酯和烯氯部分在LDA存在下进行aldol反应得到氨部分的骨架,再将手性不饱和脂肪酸和氨部分进行酰胺化反应完成了malyngamide P的合成,将P在碱性条件下进行烯醇甲基化反应完成了malyngamide O的全合成。

After light radiation time of one hour,the IC50 of cytotoxicity of C60 liposomes is 154.9 μg/ml.During the concentration of C60 liposomes are 16.86 μg/ml and 33.72 μg/ml separately,the plaque reduction rate of direct virucidal activity to HSV-1F strain is positive correlation to the time of light radiation,the correlation coefficients rate 0.8510(P.005) and 0.9766 (P.005) respectively.

光照1 h,C60脂质体对Vero细胞的细胞毒为154.9 μg/ml.C60脂质体浓度为16.86 μg/ml及33.72 μg/ml时,对HSV-1F株直接杀灭的空斑减数率与光照时间成正相关,相关系数r分别为0.8510(P.005)和0.9766(P.005);当C60脂质体浓度为16.86 μg/ml时,对HSV-1F株感染阻断的空斑减数率与光照时间正相关,相关系数r依次为0.84(P.005)及0.9923(P.005),说明C60的抗病毒作用具有时间效应,主要是光敏动力学机制起作用。

Kg(p.01).stamina index,healthy index,appetite index,sleep index,sleep time,the total count of sex arousing people and the degree concerning about the health of oneself were all reduced gradually(p.01).the counts of ailing people and using medicine people were higher in 1~3 weeks.later,the counts were reduced wavily and touched bottom in the 6th week and the 10th week respectively.the count of ailing people was reduced more obviously(p.01~0.001).the trend of disease variety among persons was that the proportion of respiratory system disease was reduced and alimentary system disease was increased gradually,the proportion of skin disease was higher at the 7th week and locomotor system disease was higher at the 8th week,the proportion of diarrhea was reduced and constipation was increased gradually.conclusion working on the reef for 3 months,the physical health status and the degree concerning about health of self of the personnel was reduced gradually.the count of ailing people and using medicine people were reduced wavily.

kg(p.01)。体能指数、健康指数、食欲指数及睡眠指数逐渐降低,睡眠时间逐渐减少,性唤起总人数比例逐渐降低,对自身健康的关心程度也逐渐降低(p.01)。患病及用药人次数以上礁后的前3周较多,此后呈波浪式逐渐减少,第6周和第10周分别降至低谷,减少幅度尤以患病人次数明显(p.01)。疾病变化趋势为呼吸系统疾病所占比例逐渐降低,消化系统疾病所占比例逐渐增加,皮肤疾病和运动系统疾病分别于第7,8周时较多;腹泻比例逐渐减少,便秘比例则逐渐增多。结论在礁3个月期间,作业人员身体状况和对自身健康的关心程度逐渐降低,患病和用药人次数呈波浪式逐渐减少。南海群礁;身体健康;患病;动态变化;医疗卫生保障

Results The expression of p16 was significantly higher in CIN than in normal cervixes(P.01),It was significanthly hi...

结果p16蛋白在CIN中的表达高于正常宫颈上皮(P.01),在宫颈癌中的表达也高于正常宫颈上皮(P.01),且高于CIN中的表达(P.05);bcl-2蛋白在CIN中的表达高于正常宫颈上皮(P.01),在宫颈癌中的表达也高于正常宫颈上皮(P.01),但与CIN中表达无差异。p16和bcl-2两种蛋白在CIN和宫颈癌中的表达无明显差异。

Results ①p53 positive expression rate in cervical carcinomas 85.71%( 30 /35) was significantly higher than that in normal cervixes 6.67%( 2 /30),P= 0.001.②p53 expression is correlated with the differentiation state and pathologic grades.The positive expression rate of p53 in the cervical carcinomas of grades Ⅰ 57.14%(8 /14) was significantly lower than that in the cervical carcinomas of grades Ⅱ 86.67%(13 /15) and grades Ⅲ 100.0%(6 /6),P<0.05.③The positive rate of PCNA in the cervical carcinoma of grade Ⅰ 64.29% was signifi cantly lower than that in the grade Ⅱ 93.33% and grade Ⅲ 100.0%,P<0.05.Conclusion Our data indicate that the alteration of p53 is involved in cervical carcinoma.

结果 ①P53蛋白在宫颈癌组织中的表达率为85.71%(30 /35),明显高于在正常宫颈组织中的表达率6.67%( 2 /30),P = 0.001;②P53蛋白阳性表达率与宫颈癌组织的病理学分级有关,P53在宫颈癌Ⅰ级中的阳性表达率57.14%(8 /14)明显低于Ⅱ级86.67%(13/15 和Ⅲ级100.0%(6/6),P<0.05;③宫颈癌组织PCNA阳性表达率Ⅰ级64.29%明显低于Ⅱ级93.33%和Ⅲ级100.0%,P<0.05。

The results show that photocatalyst TiO2 improves the removal rate of toluene in not only the nitrogen plasma field (NTP-P-O2/N2) eradiating ultraviolet light but also the argon plasma field eradiating visible light. This supports the idea that both the UV light and the high-energy electron in the plasma field can activate TiO2. Furthermore, the toluene removal rate in NTP-P-Ar system is 5% higher than that in NTP-P-O2/N2 system, confirming that high-energy electron has greater effect on the degradation performance of toluene, as compared with UV light.

结果表明:在发射紫外光的氮等离子体场(NTP-P-O2/N2)中和发射可见光的氩等离子体场中,TiO2:均能提高体系的甲苯去除率,说明等离子体场中产生的紫外光和高能电子均能激活光催化剂TiO2;NTP-P-Ar体系中的甲苯去除率较NTP-P-O2/N2:体系中的约提高5%,说明等离子体场中高能粒子对甲苯降解性能的影响要强于紫外光的影响。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

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