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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Apart from meet eight development goals be available to sb. look sth. up in a dictionary / on a website express one's opinion be meant to do sth . a successful businesswoman on behalf of work in remote places be connected to / with specialized agencies loan money to sb. set a standard for aim to sth. eliminate problems can't afford expense be lack of recommend doing sth. break down basic equipment force sb. to do sth. farm the land suffer from malnutrition be in chaos be in a mess put on weight look out for be concerned about/for get hold of remind sb. of sth remind sb. to do sth. communicate with sb. think back to be proud of = take pride in make a difference put sth.

into action from place to place die from if only in honour of on purpose 除了达到八个发展目标可以得到在字典里/网上查找表达某人的观点打算做某事一位成功的女商人作为…的代表在偏远地区工作与…有联系专业机构贷钱给某人为…确立标准目标是消除问题付不起费用缺少建议做某事出故障；抛锚基本设备强迫某人做某事种地遭受营养不良处于混乱状态乱七八糟增肥当心担心抓住让人想起提醒某人做某事和某人交流回想以…为豪发生改变使某事开始实施从一地到另一地死于只要为了表示对某人的尊敬/为了纪念某人故意的 18

Out of these investigations came the remarkable studies of the physiological action of cortisone, orACTH,and of the sex hormones.

在这批研究中，卓有成效的是对可的松或促皮质激素以及性激素生理方面的研究。

In 2003, the Press and Publication Administration, the Ministry of Information Industry, State Administration for Industry and the State Copyright Bureau, and other five ministries and commissions to combat the introduction of the "Si Fu FA BU" and "plug-in" campaign of a notice of action, Flemming believes that this notice In fact, is based on a judge is to respect any of the company's intellectual property rights, but also to respect any of the company's investment,"In any case, if you want to access other people very hard to do it out of the product, you at least make the product Owners know, the use of plug-ins to the development of business, also said that no matter how far way, but the key is that we did not have a competition in this market rules, on the contrary has become quite normal bounds."

2003年，新闻出版总署、当时的信息产业部、国家工商行政管理总局、国家版权局等五部委出台了打击"私服"和"外挂"专项治理行动的一个通知，吕本富认为，这一通知其实是基于一个判断，就是要尊重任何一个公司的知识产权，也是要尊重任何一个公司的投资，"无论如何，如果你要接入他人很辛苦才做出来的产品，你至少要让该产品的所有者知道吧，因此利用外挂去发展业务，再怎么说也是出格的手法，但关键是，我们这个市场目前没有竞争规则，出格反倒成了常事"。

Thus we are adept at understanding action in terms of the folk psychology of belief and desire, and we seem not entirely out of our depth when it comes to devising theories of language.

因而，我们擅长根据信念和希望的日常心理学来理解行为，而当设计语言理论的时候却似乎完全力所不及。

But especially that moral image suggested in Colossians 3:10; that the dominion of man over the lower creation has in some measure been lost through sin, but will be restored again in Christ (Psalm 8); that the creation of matter, of life and of man are three distinct creations out of nothing, and that God's action in them is direct, hence evolution from one into the other is impossible.

，但特别是道德形象的建议歌罗西书3：10 ；该人的统治下建立了在一定程度上已经失去通过罪恶，但将在基督再次恢复（诗篇8）；，建立的问题，生命和人是三个不同的创作无中生有，而且上帝的行动，他们是直接的，因此从一个演变成其他是不可能的。

In part one, we study the characteristics of high-tech SME-having technology dominance, strong ambition of innovation, organization agility, large number, different forms, rapid development and financing difficult, small size, familial owner management, impracticable action, mixed farming out of ability are the key problems of SMEs growing.

第一部份的主要内容包括：高新技术中小企业的经营特点——技术独特、创新意识强、数量众多、机制灵活、形式多样、发展迅速；同时存在产出规模小，融资困难，家族化管理，不切实际，盲目开展多元化经营等问题，则成为企业持续发展的瓶颈。

The second part of it has discuss the the customer value and the value chain of the retail enterprise. It also has discuss the two kinds of the customers of the retail enterprise and point out the action character of the extension customer and the connotation customer. At this part it has given out the three mode of the CRM of the retail enterprise.

由客户价值及零售企业的价值链出发对零售企业的两类客户及其关系类型进行了分析，指出了零售企业的客户行为特征，由此提出了三种零售企业的客户关系管理模式，本文归纳为综合卖场模式，专业卖场模式与品牌专卖店模式，并研究了这三种模式的各自的客户关系管理特征。

Though not one of the officers in command of the columns rode up to the ranks nor talked to the soldiers (the commanding officers, as we have seen at the council of war, were out of humour, and displeased with the plans that had been adopted, and so they simply carried out their orders without exerting themselves to encourage the soldiers), yet the soldiers marched on in good spirits, as they always do when advancing into action, especially when on the offensive.

虽然纵队的首长之中没有任何人走到队伍前面去和士兵们谈话（正像我们在军事会议上看见的那样，纵队的列位首长心绪欠佳，并对他们采取的军事行动表示不满，因此只是执行命令而已，虽然士兵们像平时一样都很愉快地去参加战斗，特别是去参加进攻的战斗，但是首长们都不去关心使士兵开心的事）。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了