查询词典 osteoclast

Objective To compare expression and distribution of CD68 protein and TRAP positive protein in ankylosing spondylitis, rheumatoid arthritis, osteoarthritis, and normal synodal tissues to study the differentiation of osteoclast in synovial tissues obtained from AS patients and its role in the pathogenesis of bone destruction in AS.

目的检测破骨细胞在强直性脊柱炎外周关节滑膜组织中的分化情况，了解破骨细胞的分化与AS患者外周关节骨质破坏病理改变的相关性。

In order to clarify the mechanisms of PEMF on osteoporosis, bone marrow cells derived from both femora and tibiae of ovariectomied rats are cultured in vitro to investigate whether osteoclast proliferation is inhibited by PEMF or not.

为了要更进一步探讨电磁场刺激抑制骨质流失的内在机转，因此本研究将以大白鼠之双侧卵巢切除为模式，取出长骨骨髓细胞做体外培养，藉此探讨特定参数单脉冲电磁场刺激是否经由对骨髓中的蚀骨细胞形成，产生抑制作用，而达到控制骨质流失的目的。

RESULTS: HE staining showed that bone resorption in Ti treatment group was increased obviously and the structure of bone trabecula was disottlerly and osteoporotic, the volume of osteoclast was enlarged and number was increased. The findings were reduced in etanercep groups, especially in 200 μg/kg group.

结果：苏木精－伊红染色结果为单纯钛处理组骨吸收明显增加，骨小梁结构紊乱及骨质疏松，破骨细胞的形态变大，数目变多；依那西普干预组上述表现减轻，尤以200μg/kg剂量为明显。

It is one of the key pathogeneses of postmenapausal osteoporosis that estrogen deficiency leads to the decrease of OPG、TGFβ expression and the increasing expression of some bone-resorbing cytokines as OPGL、M-CSF and TRAIL, then stimulates osteoclast differentiation and activity, which potentiates bone resorption and bone loss:(2) ICI182780 shows partial transactivating function in osteoblasts, so it should belong to a kind of selective estrogen receptor modulators .

雌激素缺乏可能导致HOB中OPG、TGFβ的表达减少，而解除了对OPGL、M-CSF和TRAIL等刺激OC生成和活化的细胞因子的抑制作用，OC的数量和活性增加，导致骨吸收增强和骨量丢失，这是导致绝经后骨质疏松症的一个重要的发病机制；ICI182780在成骨细胞内表现出促转录活性，因此它并非纯ER拮抗剂，而应属于选择性雌激素受体调节剂(selective estrogen receptor modulator，SERM)。

Since the osteoclast is the only cell in the body that is capable of resorbing bone, understanding its biology will be necessary for developing a new therapeutic approach for osteoporosis.

因为破骨细胞是体内唯一能吸收骨的细胞，建立治疗骨质疏松新方法有必要了解其生物学特性。

Osteoblasts are seen lining the irregular trabeculae, and there is an osteoclast near the center.

不规则骨小梁周围可见成骨细胞排列，中心部位可见破骨细胞。

At the end of the culture, PBMCs cultured on coverslips were fixed and stained for tartrate resistant acid phosphatase, a marker of osteoclast.

对培养终末细胞作组织化学染色，检测破骨细胞特征性标志物抗酒石酸磷酸酶的表达；并以象牙磨片上虫蚀样骨吸收陷窝的形成为指标检测其生物学活性。

After culture on coverslips and bovine cortical bone slices for 1, 3, 5, and 7 days, morphologic features, TRAP staining and bone absorptive lacunae were observed to evaluate osteoclast cells.

结果显示，当培养细胞在RANKL和M-CSF联合作用下，TRAP阳性染色的单核和多核破骨细胞可在3天内迅速形成，骨片吸收实验显示骨片上出现典型的骨吸收征象；在M-CSF(50ng/ml)协同作用下，RANKL呈剂量依赖型诱导TRAP阳性破骨细胞生成。

Results of IHC confirmed that ER located mainly in cytoplasms and nuclei of osteoblast, in addtion to its location in osteocyte and osteoclast, which meets the results of abroad reports.

本研究免疫组化结果证实：雌激素受体定位于成骨细胞的胞浆和胞核。除此之外，骨细胞及破骨细胞中也存在ER。这一结果与国内外研究报道相符。

In the whole life of human being, bone is always in the process of new-old alteration, which means osteoclast absorbing old sclerotin and osteoblast forming new sclerotin.

人的一生中骨骼一直处于新旧更替的过程中，即由破骨细胞吸收旧的骨质，成骨细胞形成新的骨质。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。