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In order to develop a safe and effective immunoadjuvant to enhance the immunity and resistance of animals against infection, a novel CpG Oligodeoxynucleotides containing 11 CpG motifs was synthesized and inserted into the VR1012 plasmid, designated as VR1C. Then the recombinant VR1C was entrapped with Chitosan nanoparticles prepared by the method of ionic cross linkage, and employed to inject muscularly 3-weeks old Kunming mice; the blank VR1012 packed with CNP and saline were used to inoculate mice as the control groups. 28 days after inoculation, all mice were orally fed with 0.4ml 2x108CFU/ per mouse virulent hemorrhagic enteritis E. coli to challenge the resistance against infection.

为研制安全高效免疫调节剂增强动物免疫抗病能力，本实验设计合成含11个C pG基序的寡聚核苷酸，重组构建含CpG的VR1012质粒(VR1C)；制备壳聚糖纳米颗粒包裹重组质粒(CNP-VR1C)，肌注接种3周龄昆明小白鼠，设壳聚糖包裹空质粒和生理盐水对照组；接种后28天口服大肠杆菌攻毒观察小鼠天然免疫的变化和对强毒感染的抵抗力，Sandwich ELISA测定血清免疫球蛋白和白细胞介素含量。

Methods Forty-two patients with acute critical diseases were stochastically divided into two groups, namely, the treatment group and the control; both groups were treated with routine integrated method, while the treatment group was treated additionally with rhubarb powder nasally or orally; detection was made on the hemorhcological indexes of the two groups before and after the 7 days' treatment.

42例急危重症患者随机分为2组，治疗组和对照组均接受常规治疗和病因治疗，治疗组加用大黄鼻饲或口服，分别检测2组患者治疗前和治疗7d后血液流变学各项指标的变化。

Definitive control of the airway in patients who have compromised airways due to mechanical factors, have ventilatory problems, or are unconscious is achieved by endotracheal intubation, either nasally or orally.

某些患者因机械损伤或意识丧失导致的气道通风受阻，对于此类情况可以通过经鼻或经口气管插管的方法实现呼吸道的完全通畅。

When an unanticipated intubation by direct laryngoscope was recognized, the GlideScope was used for the following tracheal intubation orally or nasally.

当以传统喉头镜插管发生未预期性困难插管时，GlideScope被使用来当成替代性插管工具，不管是经由口腔或是经由鼻腔。

Some serum samples from ducks immunized with attenuated DPV were assayed with the ELISA kit, and the antibodies were detected first on day 6 or day 9 post-immunization in ducks vaccinated subcutaneously, orally or nasally, and still detectable on day 60 PI.

应用该试剂盒对皮下注射、口服和滴鼻免疫DPV弱毒的20日龄樱桃谷鸭血液中抗DPV特异性IgG抗体效价进行了测定，皮下免疫鸭于第6d，口服和滴鼻免疫鸭于第9d可在血清中检测到DPV特异性抗体，且至第60d时依然可检测到高效价抗体。

Lucidum spore were given orally to CsA immunosuppression model mice, and the phagocytic function of macrophage and neutrophile, total hemolytic complement, weight of immune organs of the experimental mice were detected on the 2nd and 20th days after the withdrawal. Results: In mice of high, middle, and low dosage subgroups of G.

用不同剂量赤灵芝孢子粉对环孢素A模型小鼠灌胃，于停药后第2、20天分别检测小鼠腹腔巨噬细胞和中性粒细胞的吞噬功能、免疫器官重量及血清总补体活性(CH50)。

Nighty rats were randomly divided into the groups of control, myocardial infarction and doxycycline, which were given orally 48 hours before and 48 hours after MI with 30mg/Kg per day. Protein and mRNA extraction was done on left ventricular samples containing scar and myocardium together. Samples were assayed from 1 day to 4 weeks post-Mi. The activity of MMPs was measured by zymography and collagen amount by the method of chloramine T, the ratio of II III collagen was assessed by immunohistochemical stain. Protein and mRNA of MMP-2, 9, TIMP-1 were determined by Western-Blot and RT-PCR.

分为对照组、心梗组和治疗组(D组，术前两天至术后两天，口服Doxycycline，30mg／kg／天)，分别于术后第一天、术后一周、术后两周、术后四周取心肌组织，采用免疫组化测定胶原含量和Ⅰ／Ⅲ胶原比例，酶谱法测定心梗后MMP-2，9活性蛋白的表达规律，Western Blotting进一步确定酶谱法中所消化条带蛋白的属性，逆转录-聚合链反应法测定心梗后MMP-2，9和TIMP-1的mRNA的变化规律，运用Acuson Sequoia 512超声心动图机分别测定心梗组、治疗组在两周和四周时左室前壁、后壁厚度以及左心室舒张末内径和左室射血分数。

Methods 68 cases with coronary heart disease who had taken nucleic acid orally were observed for 3 years.

选择68例老年冠心病人进行了为期3年的观察。

Methods 9 cases with psoriasis who had taken nucleic acid orally for 13 to 50 months were analysed.

对口服核酸1年以上的9例老年银屑病患者进行为期13～50个月的观察。

All chickens were orally challenged with homologous sporulated oocysts at 26 days of age and killed at eight days post challenge. Weight gains, anticoccidial index and oocyst output were determined and compared with those of the control animals.

以可溶性的GST-gam56-2融合蛋白为免疫原，设立高、中、低(1.0 mg、0.5 mg、0.25 mg) 3个剂量，单独或使用弗氏完全佐剂，于5 d、12 d和19 d对雏鸡进行3次免疫， 26 d用5×104个E.maxima孢子化卵囊进行攻虫，8 d后迫杀，对各组的存活率、相对增重率、卵囊减少率、ACI等指标进行统计分析。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失