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The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps-: a coupling step, using an excess of an activated carboxylic component to acylate an amino component, a quenching step in which a scavenger is used to remove residual activated carboxylic functions, wherein the scavenger may also be used for deprotection of the growing peptide, one or more aqueous extractions and optionally, a separate deprotection step, followed by one or more aqueous extractions, characterised in that the process comprises at least one step, referred to as step, in which an amine or a thiol comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions.

本发明涉及快速溶液合成肽的方法,该方法包括步骤-的重复循环:偶联步骤,使用过量的活化羧基成分酰化氨基成分,淬灭步骤,在该步骤中使用清除剂除去残余的活化羧基官能团,其中该清除剂还可以用于使生长中的肽去保护,一或多个水抽提和任选地,独立的去保护步骤,之后进行一或多次水抽提,其特征在于该方法包括至少一个步骤,称作步骤,在该步骤中包含自由阴离子或潜阴离子的胺或硫醇用作残余活化羧基官能团的清除剂。

Since C6 and higher alcohols are not obtainable by a direct biochemical route, it is proposed to synthesize these using known chemical reactions, wherein the raw material for synthesis is biogas and lower C2-C5 alcohols obtained by the inventive method wherein the amino acids leucine, isoleucine, and valine, or a mixture thereof, optionally obtained from yeast autolysate, is used as a biocatalyst at the stage of fermentation.

因为C6和更高级醇类不能通过直接生物化学途径制得,所以提出用已知的化学反应合成这些化合物,其中合成的原料为本发明方法制得的生物气和C2-C5醇类,其中任选从酵母自溶作用得到的亮氨酸、异亮氨酸和缬氨酸或其混合物的氨基酸在发酵阶段用作生物催化剂。

If you have Backgrounder installed, you can optionally set the current application to background upon switching (unbackground via the normal Backgrounder method). This option can be enabled in the LastApp preferences pane in Settings.app.

如果你安装了backgrounder,你可以选择是否在切换的时候将当前的软件后台运行(可以通过正常的后台方式来解除后台运行)这个选项需要你在设置里的LastApp设置里面打开。

Phoenix town is original and simple, which has much contradiction with the modern times. These boat trackers who still cry out belong Tuojiang River,these women who wrapped with coarse cloth and decorated with silver, these abrupt electric perches and swing wire in the sky of old town, these colorful cutain and bed sheet are optionally hanged on gate baluster of the town.

那些沱江上游依然吆喝着号子的纤夫们,那些吊脚楼前用银饰和粗布裹满全身的湘西女人们,那些沿着古街一字排开挤得密密的突向街道的吊脚楼,那些突兀在古镇当中在空中游走的电杆和电线,那些花花绿绿的随意搭在楼门栏杆上的印花布门帘床单,那些隔离了城市的喧嚣而依然热闹的杂吵吆喝与闲谈的声响,他们,她们,或者它们!

Stainless steel 35-42 °Be FeCl 3 35-55 Mild steel 35-42 °Be FeCl 3 35-55 Beryllium copper 30-42 °Be FeCl 3 or 40-55 ammoniacal copper or 33 °Be acidic CuCl 2 Copper and copper 30-42 °Be FeCl 3 or 40-55 alloys ammoniacal copper or 33 °Be acidic CuCl 2 Inconel and other 38-42 °Be FeCl 3 or 45-55 high nickel alloys conc nitric/conc hydrochloric acid/water 1:1:3 Aluminium 20% NaOH 60-90 or conc hydrochloric 20-65 acid/water 1:4 55 or alkaline potassium ferricyanide Brass 30-42 °Be FeCl 3 or 40-55 ammoniacal copper or 33 °Be acidic CuCl 2 Molybdenum Alkaline potassium 55 ferricyanide 40-55 or 40 °Be Fe(NO 3 ) 3 Titanium 10-50% HF 30-50 (optionally with HNO 3 )*The concentration of etchant (column 2) is measured in Degrees Baume where:°Be = 145 (SG - 1/SG); and SG is the specific gravity of the solution.

表美- 00002表2金属共同腐蚀剂*温度° C的不锈钢35-42 °成为氯化铁三 35-55低碳钢35-42 °成为氯化铁三 35-55铍铜30-42 °成为氯化铁3或40-55氨铜或33 °是酸性CuCl的2铜及铜30-42 °成为氯化铁三或40-55合金氨铜或33 °是酸性CuCl的2镍铬铁合金和其他38-42 °成为三氯化铁3或45-55高镍合金浓硝酸/浓盐酸/水1时01分03秒铝20%的NaOH浓盐酸60-90或20-65酸/水1:4 55或氰化钾铜30-42 °碱性钾成为三氯化铁3或40-55氨铜或33 °是酸性CuCl的二钾55钼碱性铁氰化钾40-55或40 °成为铁Fe(NO 3)3钛10-50%的HF 30-50*的浓度对侵蚀剂(栏2)测量波美度其中:°成为= 145(法兴- 1/SG);和SG是比重。

With this, you can optionally turn on interception of CR and/or LF as well as line blanking on new lines.

有了这个,你可以选择打开的CR拦截和/或LF以及在新的行线消隐。

The Chinese pharmaceutical compositions of the present invention are prepared from, by weight, 20-50 parts of borneol, 20-50 parts of ammonium chloride, and 20-50 parts of catechu by grounding into fine powder, mixing, and optionally combining with pharmaceutically acceptable carriers or excipients to yield desired dosage forms.

可近年来,世界上某些地区及中国的部分地区仍有少数零散发病,使用抗菌素救治无效。

Each shortcut can optionally be associated with a hot key combination.

每一个捷径,可以选择性地联系在一起的一个热门组合键。

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本发明涉及右式化合物其N-氧化物、盐、立体异构形式、外消旋混合物、前药、酯及代谢物,其中R 1 及R 8 各是氢、C 1-6 烷基、C 2-6 烯基、C 3-7 环烷基、芳基、Het 1 、Het 2 ;R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基;t是0、1或2;R 2 是氢或C 1-6 烷基;L是-C-、-O-C-、-NR 8 -C-、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-、-S 2 -,-O-S 2 -、-NR 8 -S 2 -;R 3 是C 1-6 烷基、芳基、C 3-7 环烷基、C 3-7 环烷基C 1-4 烷基或芳基C 1-4 烷基;R 4 是氢、C 1-4 烷基OC、羧基、氨基C、一-或二(C 1-4 烷基)氨基C、C 3-7 环烷基、C 2-6 烯基、C 2-6 炔基或任选被取代的C 1-6 烷基;R 5 及R 6 是氢或C 1-6 烷基。

A process for making an electronic device which comprises applying a nonaqueous plate-resistant ink by ink jet printing to selected areas of a dielectric substrate, optionally laminated with an electrically conductive metal, exposing the plate resistant ink to actinic and/or particle beam radiation to effect polymerisation, adding one or more metal layers by electrolytic or electroless deposition, the upper layer of which is an etchresistant metal, removing the polymerised plate-resistant ink with alkali and finally removing the electrically conductive metal which are optionally directly laminated to the dielectric substrate and not protected by an upper layer of etch-resistant metal by chemical etching wherein the plate-resistant ink is substantially solvent-free and comprises: A 30 to 90 parts acrylate functional monomers free from acid groups comprising mono- or higher functionality wherein 5 to 95% by weight are mono-functional monomers; B 1 to 30 parts acrylate functional monomer containing one or more acid groups; C 0 to 20 parts polymer or prepolymer; D 0 to 20 parts radical initiator; E 0 to 5 parts colorant; F 0 to 5 parts surfactant; and where the ink has a viscosity of not greater than 30 cPs at 40 DEG C and all parts are by weight.

一种制备电子装置的方法,所述方法包括以下步骤:通过喷墨印刷在任选层压了一种或多种导电金属的介电底材的选定区域涂覆非水的阻沉积油墨,将所述阻沉积油墨暴露在光化辐射和/或微粒束辐射中以完成聚合,通过电解沉积或无电沉积增加一层或多层金属层,其中最上层的金属层为一种或多种阻蚀刻金属,用碱除去聚合的阻沉积油墨,最后通过化学蚀刻将任选直接层压在所述介电底材上并且不被一种或多种阻蚀刻金属的上层保护的导电金属除去,其中所述阻沉积油墨基本不含溶剂,并且包含以下组分:A30-90份不含酸基团的丙烯酸酯功能性单体,所述单体包括单官能或多官能单体,其中5-95%重量为单官能单体;B1-30份包含一个或多个酸基团的丙烯酸酯功能性单体;C0-20份聚合物或预聚物;D0-20份自由基引发剂;E0-5份着色剂;和F0-5份表面活性剂;其中所述油墨的粘度在40℃下不高于30cPs,并且所有的份数以重量计。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力