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The present invention provides an aqueous adhesive composition including a resinous phase dispersed in an aqueous medium, the resinous phase containing a polychloroprene, optionally, a halogenated polyolefin different from, and optionally, an aminoplast resin.

本发明提供了包括分散于水性介质中的树脂相的水性粘合剂组合物，该树脂相包含聚氯丁二烯；任选的不同于的卤化聚烯烃；和任选的氨基塑料树脂。

The method involves exposing the cells to a compound having the formula I in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a spacer having a chain length equivalent to 1-30 carbon-carbon single covalent bonds or is absent R4 is H or halogen or CH2O-R3; and R1, R2 and R3 are the same or different and are either hydrogen, methyl, ethyl, alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl groups or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl groups optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that at least one of R1, R2 or R3 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated, or to a compound having the formula II in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a space having a chain length equivalent to 1-30 carbon-carbon single covalent bonds or is absent, R5 is alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl group or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl group optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that R5 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated.

该方法包括使细胞暴露于具有式的化合物，在式中：w是核酸，x是非氨基酸或者非肽核酸结合基团，y是具有等于1―30个碳―碳单共价键的链长的间隔基或者不存在，R4是H或者卤素或者CH2O－R3；R1、R2和R3是相同的或者不同的并且是氢、甲基、乙基、烷基、链烯基、羟基化烷基、羟基化链烯基或者包含烷基、链烯基、羟基化烷基或羟基化链烯基的醚，任选地是来源于具有等于3―24个碳原子的碳链长的饱和或不饱和脂肪酸的酰基，其条件是R1、R2或者R3的至少一个包括具有3―24个碳原子的饱和或不饱和碳链的基团，或者使细胞暴露于具有式的化合物，在式中：w是核酸，x是非氨基酸或者非肽核酸结合基团，y是具有等于1―30个碳―碳单共价键的链长的间隔基或者不存在，R5是烷基、链烯基、羟基化烷基、羟基化链烯基或者包含烷基、链烯基、羟基化烷基或羟基化链烯基的醚，任选地是具有等于3―24个碳原子的饱和或不饱和碳链的链长的酰基，其条件是R5包括具有3―24个碳原子的饱和或不饱和碳链的基团。

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

Firstly, proem, it concise introduces the background ; Secondly, it introduces the reform of the commission system and the dilemma of the securities companies in our country; Thirdly, it puts forward the idea of implementation of "Optionally differential strategies " as the natural choice for the future development of the securities brokers in our country , through the analysis of the current competitive environment of the securities companies in our country and study on the alternatives of competitive strategies ; The forth , it describes how to practice " Optionally differential strategies",which including three aspect: the choice of the core competition ability, the measures for the implementation are brought forth ,and the condition of practice the strategies; The fifth, it s the summary of the dissertation.

第一部分，简介论文写作背景；每二部分，介绍我国佣金制度改革以及改革后我国证券公司所面临的困境；第三部分，通过对现阶段我国证券公司竞争环境的分析，进行竞争战略选择研究，提出实施选择性差别化战略应成为我国证券商未来发展的必然选择。第四部分，提出"选择性差别化战略"的实施措施，包括拓展业务领域、拓宽交易渠道及改革证券商管理模式三方面可操作的内容；第五部分，对全文作概括性的总结。

New sulfonyloxadiazolones have the formula, in which A stands for hydrogen, sulphur,-SO-,-SO2- or a group, in which R stands for hydrogen or alkyl; R stands for optionally substituted cycloalkyl, cycloalkenyl or aryl; and R stands for optionally substituted alkyl, alkenyl, dialkylamino or aryl.

本发明涉及式新的磺酰基__二唑酮，其中，A代表氧、硫、－SO－、－SO 2 －或基团，其中R 3 代表氢或烷基；R 1 代表任选被取代的环烷基，任选被取代的环烯基或任选被取代的芳基；和R 2 代表任选被取代的烷基，链烯基，二烷基氨基或芳基。

The present invention relates to compounds of formula wherein R is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkyl substituted by halogen; R is hydrogen or halogen; or R and R are together with the carbon atom to which they are attached -CH=CH-CH=CH-; R is hydrogen, lower alkyl, phenyl optionally substituted by halogen, or is hetaryl, optionally substituted by lower alkyl; R is hydrogen, lower alkyl, phenyl, benzyl, lower alkenyl, lower alkoxy, phenyloxy, benzyloxy, S-lower alkyl, halogen, CN, lower alkyl substituted by halogen or O-lower alkyl substituted by halogen; R is hydrogen or lower alkyl, aryl is phenyl or naphthyl; n is 1, 2 or 3; m is 1 or 2; and pharmaceutically acceptable acid addition salts and tautomeric forms thereof.

本发明涉及式化合物及其可药用的酸加成盐和互变异构形式，其中R 1 是氢、低级烷基、低级烷氧基、卤素或被卤素取代的低级烷基；R是氢或卤素；或R 1 和R与它们连接的碳原子一起是-CH＝CH-CH＝CH-；R 2 是氢、低级烷基、任选被卤素取代的苯基或者是任选被低级烷基取代的杂芳基；R 3 是氢、低级烷基、苯基、苄基、低级链烯基、低级烷氧基、苯氧基、苄氧基、S-低级烷基、卤素、CN、被卤素取代的低级烷基或被卤素取代的O-低级烷基；R 4 是氢或低级烷基，芳基是苯基或萘基；n是1、2或3；m是1或2。

Wherein X is an oxygen atom or a sulfur atom; C*, C** and C*** are asymmetric carbons; R 1 , R 2 , R 4 , R 5 , R 8 , R 9 and R 10 are each a lower alkyl group optionally having substituent and the like, or R 4 and R 5 and the like in combination optionally form a homocyclic ring optionally having substituent and the like; R 3 is an aryl group optionally having substituent and the like; R 6 and R 7 are each a hydrogen atom and the like; Nu is -CR 16 (COR 17 )(COR 18 ) wherein R 16 , R 17 and R 18 are each a lower alkyl group optionally having substituent and the like, and the like; and EWG is an electron withdrawing group.

通式中，X代表氧或硫；C *、C **和C ***分别表示不对称碳；R 1 、R 2 、R 4 、R 5 、R 8 、R 9 和R 10 分别代表任选取代的低级烷基等，条件是例如R 4 和R 5 可以相互结合形成任选取代的同素环等；R 3 代表任选取代的芳基等；R 6 和R 7 分别代表氢原子等；Nu表示-CR 16 (COR 17 )(COR 18 )(其中R 16 、R 17 和R 18 分别代表任选取代的低级烷基等)等；并且EWG表示吸电子基团。

A composition that can be used as catalyst is disclosed, which comprises or is produced by combining, a titanium compound; either a complexing agent, a combination of a complexing agent, hypophosphorous acid or a salt thereof, and optionally a solvent, a zirconium compound, or both, combinations thereof; a phosphorus compound; and, optionally, a solvent.

公开了一种可用作催化剂的组合物，该组合物包括钛化合物；络合剂，或络合剂、次磷酸或其盐和选择性使用的溶剂、锆化合物或二者的组合，或它们的组合；磷化合物和选择性使用的一种溶剂；或是用它们的组合制成的催化剂。

A chromium free conversion coating at least equivalent in corrosion protective quality to conventional chromate conversion coatings can be formed on metals, particularly cold rolled steel, by a dry-in-place aqueous acidic liquid comprising: a component of anions, each of said anions consisting of at least four fluorine atoms and at least one atom of an element selected from the group consisting of titanium, zirconium, hafnium, silicon, and boron, and, optionally, ionizable hydrogen atoms, and optionally, one or more oxygen atoms; a component of cations of elements selected from the group consisting of cobalt, magnesium, manganese, zinc, nickel, tin, zirconium, iron, and copper; the ratio of the total number of cations of this component to the total number of anions of component being at least 1:5; sufficient free acid to give the composition a pH in the range from 0.5 to 5.0; a component selected from the group consisting of phosphorus-containing inorganic oxyanions and phosphonate anions; and a component selected from the group consisting of water-soluble and water-dispersible organic polymers and polymer-forming resins and, preferably, also including a component selected from the group consisting of tungstate, molybdate, silicotungstate, and silicomolybdate anions.

通过对包含以下成分的含水酸性液体进行干燥，可以在金属上形成无铬的转换涂层，该涂层与普通铬酸盐转换涂层相比，至少在抗腐蚀质量上等效：$_一种阴离子成分，所述各个阴离子包括至少4个氟原子，至少选自钛、锆、铪、硅与硼元素中的1个原子。任选地可离解的氢原子，任选地1个或多个氧原子；$_一种选自钴、镁、锰、锌、镍、锡、锆、铁与铜元素的阳离子成分，上述成分的阳离子总数与成分内的阴离子总数之比至少为1∶5；$_足够的游离酸以使该组合物的pH值在0.5～5.0的范围内；$_一种选自含磷的无机含氧阴离子与膦酸盐阴离子的成分；$一种选自水溶性与水可分散性有机聚合物与聚合物形成的树脂的成分，优选还包括一种选自钨酸盐、钼酸盐、钨硅酸盐与钼硅酸盐阴离子的成分。

This invention pertains to compounds of Formula I, their N-oxides and suitable salts wherein A is O or S; G is a 5- or 6-membered heteroaromatic ring or a 5- or 6-membered nonaromatic heterocyclic ring optionally including one or two ring members selected from the group consisting of C, SO or S2, each ring optionally substituted with from one to four R; each J is independently a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system, wherein each ring or ring system is optionally substituted with from one to four R; and R, R, R, R and n are as defined in the disclosure.

本发明涉及式I的化合物、其N-氧化物和适当盐，其中A是O或S；G是任选地包含一个或两个独立选自C、SO或S 2 的环成员的5-或6-员杂芳环或5-或6-员非芳族杂环，各环任选地被1-4个R 2 取代；各J独立地是苯环，5-或6-员杂芳环或芳族8-，9-或10-员稠合的碳二环或杂二环系，其中各环或环系任选地被1-4个R 3 取代；R 1 ，R 2 ，R 3 ，R 4 和n如说明书中定义。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。