查询词典 oncogenes

The article focuses on the aberrant expression and significances of proto-oncogenes, tumor suppressor genes and genes associated with the proliferation process of gastric cells such as telomerase, transcription factor and cyclooxygenase, etc. These genes, alone or synergically, participate in gastric cancer cell proliferation, resulting in an uncontrolled growth characterized by over-proliferation of decreased apoptosis of gastric cancer cells.

本文着重阐述了与胃癌细胞增殖过程密切相关的端粒酶、核转录因子、环氧化酶等基因以及参与细胞周期调控的原癌基因、抑癌基因的异常表达及临床意义，这些基因或单独作用，或相互协同，参与胃癌细胞的增殖，使肿瘤细胞生长以增殖过多、凋亡过少的失控性生长为特征。

During this process, the genetic alteration includes the activating of oncogenes and inactivating of tumor suppressor genes.

在这个过程中，存在着癌基因的激活和抑癌基因的失活等一系列的遗传学改变。

Several closely related transcription factors also function as translocated oncogenes in various human malignancies.

一些密切相关的转录因子也可作为转基因在不同人的恶性肿瘤。

Ecause bcl-2 protein could block the anoikis signaling pathway, which has become one of the most important oncogenes in anoikis studies.

cl-2成为anoikis凋亡研究中最受重视的癌基因之一，其实质是通过阻断细胞凋亡信号传递系统的最后通道而抑制细胞凋亡。

One mechanism that stops cell proliferation is a family of tumor-suppressor proteins that bind to and block the function of proto-oncogenes, or genes that have the potential to trigger cancer.

一个停止细胞扩散的机制是一个肿瘤抑制蛋白家族，其作用是约束和阻止原功癌基因即有可能引发癌症的基因。

In vertebrate organisms,thesignaling pathway is initiated by the binding of ligandsto the membranousreceptor patchedwhich in turn alleviates the suppression on smoothened,subsequently Smo triggers a series of intracellular events with resultant activation of thezinc-finger transcription effectors,glioma-associated oncogenes(Glil,Gli2,Gli3)transcription factor,which induces the expression of numerous target genes,such as Ptch-1,Hip,Gli1 and Wnt,that regulate proliferation,differentiation.

Hedgehog信号通路是高度保守的调控胚胎组织分化发育的通路，在脊柱动物体内，Hh蛋白与跨膜受体Ptch结合后，解除了Ptch对Smo的抑制，随后Smo从共受体上解离下来进入胞浆，将信号下传并激活锌指转录因子Gli，后者启动Ptch-1、Hip、Gli1、Wnt等目的基因的表达，进而调控细胞的增殖、分化。

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.Cell,1991;

这些结果证实适当的细胞周期控制，特别在干/祖细胞早期阶段，是保持正常造血所必需的。

Objective: To study the characteristic of primary cells of human renal cell carcinoma and expression of the oncogenes.

目的：研究人肾细胞癌原代细胞生物学特性及其癌基因的表达情况。

The activation of oncogenes occured in most tumors, and is believed to play an important role in tumorigenesis.

在大部分的肿瘤中都发现有癌基因的活化，癌基因的活化被认为是导致肿瘤发生的重要原因。

There were 45% and 20% coexpression of two or three oncogenes respectively in group M,75% and 25% in group NM.

有2种或3种癌基因同时表达的，M组分别为45%、20%；NM组分别为75%、25%。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。