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Results: 1 Intense ERα immunoreactivity localized in the hypertrophic and maturative layer, and some immunoreactivity was found in osteoblasts of mandible and temporal bone, while no immunoreactivity was found in the disc and synovium. 2 The expression of ERα in male rats TMJ cartilage was higher than that in female ones. 3 In the condyle cartilage of male rats, the density of ERα positive cells decreased with age, which kept stable after 16 weeks of age. 4 In the condyle cartilage of male rats, the density of ERα positive cells was stable from birth to 8 weeks, but decreased from 16 weeks to 12 months, while the density in 18-month group recovered to the level of 8 weeks. Conclusion: TMJ is one of target organs of estrogen, and ERα plays an important role in the effect of estrogen on TMJ.

结果：1TMJ中ERα主要在髁突软骨的肥大层和过渡层表达，下颌骨和颞骨的骨细胞也有少量表达，而关节盘、滑膜中几乎无表达；2雄性SD大鼠髁突软骨中ERα的表达明显强于同龄的雌性大鼠；3在雄性大鼠TMJ髁突软骨中阳性细胞密度随年龄增长逐渐降低，16周以后逐渐维持在相对稳定的水平；4雌性大鼠从出生后到8周龄阳性细胞密度基本稳定，在16周龄至12月龄年龄组阳性细胞密度显著降低，而在18月龄后又恢复到8周龄以前的水平。

Methods Six weeks old male Fischer 344 rats (F344) were used as donors, and six weeks old male F344alb as recipients. All F344alb were divided into 4 groups: group Ⅰ(n=10) was untreated; group Ⅱ(n=10) was treated with CCl4 but no γ-irradiation and transplantation; group Ⅲ(n=10) was transplanted with 1×10^7 BMCs after γ-irradiation, but without CCl4 treatment; group Ⅳ(n=10) was transplanted with 1×10^7 BMCs after γ-irradiation, with CCl4 treatment. The BMCs prepared from the donors were infused via the penial veins of recipients immediately after whole body γ-irradiation (7.5Gy) and CCl4 treatment: 4 weeks after BMCs transplantation, CCl4 were injected into peritoneal cavity twice a week for 4 weeks.

雄性F344大鼠为供体，而雄性F344alb为受体，分为4组：组Ⅰ(n=10)为正常对照组，不接受肝损处理，无全身射线照射和阴茎静脉骨髓细胞移植；组Ⅱ(n=10)为肝损无移植组，只接受肝损处理，无全身射线照射和阴茎静脉骨髓细胞移植；组Ⅲ(n=10)为正常移植组，全身射线照射后阴茎静脉移植骨髓细胞1×10^7；组Ⅳ(n=10)为肝损移植组，接受CCl4注射肝损，全身射线照射后阴茎静脉骨髓细胞移植1×10^7BMCs，其中，γ-照射剂量为7.5Gy，F344大鼠的BMCs经受体的阴茎静脉注入。

Results a follow-up of 4～12 months showed that of 39 cases with a 100% of fracture union.the bone union of roentgenographic evidence was at 2～4 weeks,mean 2.9 weeks.the patients went back to their jobs between 3～12 weeks (mean 4.6 weeks).according to the evaluation of the total active movement scales,excellent and good results were achieved in 36 cases,with an excellent and good rate of 92.3%.

结果 术后39例得到4～12个月随访，骨折愈合率为100%。x线片示骨折愈合时间为2～4周，平均2.9周。重返工作岗位时间为3～12周，平均4.6周。根据tam系统评价法评定手指功能恢复情况，36例优良，优良率为92.31%。

Methods Forty mice were randomly divided into 4 groups: one normal control group,mice in the other three groups were all infected each with 25 cercariae, the infected control group was fed for 10 weeks after infection, and 2 weeks after infection, the high dose PTX group was given PTX 360 mg/ for 8 weeks and the low dose PTX group was given PTX 180 mg/also for 8 weeks.

将40只小鼠随机分为4组，其中3组每只小鼠人工感染日本血吸虫尾蚴25条，1组感染后继续喂养10周，不作治疗，作为感染对照组；2组分别于感染后2周用PTX 360 mg/和180 mg/灌胃治疗8周；另1组不感染、也不接受药物治疗，与上述3组同步喂养10周，作为正常对照组。10周后将上述4组小鼠分别剖杀取肝组织，光镜观察肝组织病变；用免疫组化染色方法检测小鼠肝组织中Bcl-2、Bax的水平。

The action duration of tetracycline on the activities of soil urease, catalase, sucrase and proteinase were 7 weeks, 6-8 weeks, 7 weeks, and 6-7 weeks, respectively.

四环素对土壤脲酶、过氧化氢酶、转化酶和蛋白酶活性的作用时间分别为：7周、6~8周、7周和6~7周。

The results showed that (1) COX-2 mRNA and protein existed in the mature male rat testis. COX-2 was localized in spermatocytes by immunohistochemistry.(2) COX-2 also existed in adult man testis. COX-2 protein was positively stained in spermatocytes and Leydig cells.(3) 2 weeks after administration of rofecoxib, the level of testosterone in the whole testis reached its lower values, being only 50% of control values. However, testosterone level recovered during 4 weeks. After such treatment, histologic examination of these testes showed atrophy of the seminiferous tubules and maturation arrest of spermatogenesis.(4) 2 weeks post-EDS, expression of COX-2 decreased significantly (P.005), in comparison with vehicle-treatment control. 4 weeks after treatment, a new generation of fetal like Leydig cells repopulated in the testicular interstitium resulting in COX-2 expression partially recovered. Although the expression of COX-2 mRNA and protein are enhanced at 8th week after using external testosterone, it wasn't significant higher than control group.

实验研究证明：(1)正常成年雄性大鼠睾丸组织中COX-2在mRNA和蛋白质水平均存在表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞；正常成年男性睾丸组织中同样存在COX-2表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞和Leydig细胞；(2)服用特异性COX-2酶抑制剂rofecoxib 2周后，实验组大鼠睾丸组织内睾酮的含量减少，为正常对照组的50％；持续用药4周后睾丸组织内睾酮浓度逐渐恢复至正常水平；COX-2酶活性降低后病理组织切片显示睾丸内曲细精管萎缩，生精紊乱，持续用药4周时影响最明显；(3)注射特异性Leydig细胞杀灭剂EDS 2周后，实验组大鼠睾丸组织内睾酮浓度降至极低水平时，COX-2的蛋白和基因表达水平也显著低于正常空白对照组（P.005）；使用EDS后第4周，睾丸组织中的睾酮浓度逐渐回升，同样组织中COX-2蛋白表达和mRNA表达水平也相应提高接近正常水平；使用EDS后4周开始给予外源性睾酮，6周和8周时COX-2表达水平的绝对值虽有提高，但与正常大鼠空白对照组比较并无显著性差异，说明外源性雄激素刺激睾丸合成COX-2的作用并不明显。

Methods:After 1-week washout and 2-week placebo run-in period,patients with seated diastolic blood pressure 95-115 mmHg (n=76) were administrated with losartan 50 mg once-daily or losartan 50 mg/hydrochlorothiazide 12.5 mg once daily for 4 weeks,followed by double doses once daily for another 4 weeks in those patients with SeDBP≥90 mmHg.

坐位舒张压95～115 mmHg(1 mmHg=0.133 kPa)的76例原发性高血压患者，经1周药物洗脱期，2周安慰剂期后，随机服用氯沙坦50 mg(氯沙坦组，n=37)，每日1次或氯沙坦50 mg与双氢克尿噻12.5 mg合剂(氯沙坦+双氢克尿噻合剂组，n=39)，每日1次。4周末坐位舒张压≥90 mmHg者，剂量分别加倍，继续服用4周。

Pretty boy 歌手:m2m 专辑:shades of purple I lie awake at night See things in black and white I've only got you inside my mind You know you have made me blind VERSE 2 I lie awake and pray That you will look my way I have all this longing in my heart I knew it right from the start M2M CHORUS Oh my pretty pretty boy I love you Like I never ever loved no one before you Pretty pretty boy of mine Just tell me you love me too Oh my pretty pretty boy I need you Oh my pretty pretty boy I do Let me inside Make me stay right beside you VERSE 3 I used to write your name And sometime I think I hear you call Right from my bedroom wall VERSE 4 You stay a little while And touch me with your smile And what can I say to make you mine To reach out for you in time CHORUS BRIDGE Oh pretty boy Say you love me too CHORUS My Love歌词歌手:Westlife an empty street, an empty house, a hole inside my heart, i'm all alone and the rooms are getting smaller. i wonder how, i wonder why, i wonder where they are, the days we've had, the songs we've sang together. and oh my love, i'm holding on forever, reaching for a love that seems so far, so i say a little prayer, and hope my dreams will take me there, where the skies are blue to see you once again, my love, over seas from coast to coast, to find the place i love the most, where the fields are green to see you once again, my love. i try to read, i go to work, i'm laughing with my friends, but i can't stop to keep myself from thinking.. i wonder how.. i wonder why i wonder where they r the days we had, the songs we sang together and oh my love..... i m holding on forever, reachign for the love that seems so far..... so i say a little prayer and hope my dreams will take me there, where the skies are blue to see you once again, my love, over seas from coast to coast, to find the place i love the most, where the fields are green to see you once again, to hold u in my arms, to promise u my love, to tell u from my heart..... what i m thinking offfff reaching for the love that seems so far.. so i say a little prayer.... and hope my dreams will take me there... where the skies are blue to see you once again, my love, over seas from coast to coast, to find the place i love the most, where the fields are green to see you once again, my love.

pretty boy 偷偷看你的脸心情变成晴天我向着窗外默默想念希望你能听得见你的好你的坏全部我都想爱你明不明白说不出来心中对你的依赖 Oh my pretty pretty boy， I love you 因为窈窕妹妹不会假装爱 Pretty pretty boy of mine 对你说声嗨 Oh my pretty pretty boy， I need you， oh my 窈窕妹妹只想爱说你不走，要你别走，请留下来看别人手牵手我越看越寂寞我想要你说只对我说说你心中只有我你明明很爱我明明不想要走为什么不敢付出太多是不是怕真爱上我 Oh my pretty pretty boy， I love you 因为窈窕妹妹不会假装爱 Pretty pretty boy of mine 对你说声嗨 Oh my pretty pretty boy， I need you， oh my 窈窕妹妹只想爱说你不走，要你别走，请留下来 Oh my pretty pretty boy 说你也爱我 Oh my pretty pretty boy， I love you 因为窈窕妹妹不会假装爱 Pretty pretty boy of mine 对你说声嗨 Oh my pretty pretty boy， I need you， oh my 窈窕妹妹只想爱说你不走，要你别走，请留下来 my love 一条空街一间空房子一个伤口在我心里我完全陷入孤独，感觉房子越来越小我不明白怎么了我不明白为什么我不知道它们都去了哪儿那些我们共同在一起的日子和共同唱过的歌哦，我的爱我将永远坚持为一个看似很远的爱情而坚持不懈所以我默默做了一个祈祷希望我的梦把我带到那个地方那个有蓝天的地方，我再次见到你，我的爱人跨越大海穿越海岸找到我最喜欢的地方那个绿数成荫的地方，我再次见到你，我的爱人我努力读书我每日工作我和朋友们说笑但我不能让自己停止想念你我不明白怎么了我不明白为什么我不知道它们都去了哪儿那些我们共同在一起的日子和共同唱过的歌哦，我的爱我将永远坚持为一个看似很远的爱情而坚持不懈把你抱在怀里向你承诺我的爱发自内心的告诉你你是我想要的全部为一个看似很远的爱情而坚持不懈

Squalene/Arlacel A(4:1)–MDP was used as adjuvant. First injection with 500 ug antigen was given to each animal, and three injection once two weeks with 250 ug antigen were followed. Serum Anti-ZP antibody response was evaluated by ELISA once two weeks. In eighth week after first injection, all female monkeys were encaged wi

在高等灵长类动物免疫研究证明去糖基卵透明带抗原免疫能产生抗生育作用，但不会引起卵巢功能紊乱等不良反应，糖基是导致免疫动物卵巢功能紊乱成分，为选择卵透明带抗原，用重组基因技术发展卵透明带避孕疫苗提供依据。

Results: The prevalence rates within two weeks among the elderly were 29.7% and 64.7%, and the rates of seeing a doctor within two weeks were 9.5% and 34.7% in urban community and rural areas respectively. The prevalence rates of chronic diseases were 62.1% and 56.4% in city and rural area respectively. Sixty-six point nine percent of the elderly in urban community went to high-level hospitals for medical services, while 73.3% of old people in rural area went to village clinics. The main reasons for diseased people not to visit a doctor were self feeling of slight illness (21.7%) and self-treatment (51.6%) in urban community and were low income (40.8%) and self feeling of slight illness (25.9%) in rural areas. The main affecting factors to rates of seeing a doctor within two weeks were increased age and family income per capita among the elderly in urban community, and were suffering or not suffering from chronic diseases in rural area.

结果：城市和农村社区老年人的两周患病率分别为29.7%和64.7%，两周就诊率为9.5%和34.7%，慢性病患病率分别为62.1%和56.4%；城市老年人就诊地点主要以县市级和省级医院为主，两者所占比例为66.9%；农村则以个体诊所或村卫生室为主，占73.3%；两周患者未就诊原因在城市主要是自感病轻（占21.7%）和自我医疗（占51.6%），在农村主要为经济困难（占40.8%）和自感病轻（占25.9%）；影响老年人两周就诊的因素在城市为年龄和家庭人均月收入，在农村是患慢性病与否。

You think you're a big shot.

你认为你是一个大人物？

All states are equal, and none can receive special treatment from the federal government.

所有的州都是平等的，任何州都不能获得联邦政府的特别待遇。