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The relationships of VEGF with the indices of renal damage, including renal/body weight, urinary protein excretion, glomerular volume and glomerular area, were analyzed. Results The expression of VEGF mRNA in diabetic kidney was significantly up-regulated after operation from 2 weeks to 24 weeks with the peak level at 20weeks, when compared with control at the same time- points. The positive results of VEGF staining in diabetic glomeruli was increasingly observed after operation from 2 weeks to 24 weeks, with the peak at 20 weeks. The positive results of VEGF staining in diabetic tubuli was increasingly seen from 2 weeks to 24 weeks, with the peak at 8 weeks.

结果 VEGF mRNA在糖尿病模型组大鼠肾脏中持续高表达，各时点与对照组相比差异均有统计学意义(P.05)；糖尿病组2~24周肾小球VEGF蛋白表达强于对照组(P.05)，24周时有所减弱，但仍强于对照组；糖尿病组各时点肾小管VEGF蛋白表达均强于对照组(p.05)， 8周后表达明显增强；VEGF表达变化与肾质量／体质量(r=0.518， P＝0.001)、尿蛋白(r=0.409， p=0.001)、肾小球面积(r=0.499， P-0.000)和体积(r=0.499， P-0.000)呈正相关。

Bosson--One In A Million You're one in a million, Oh now You're one in a million, Oh Sometimes I can't hate you every day Sometimes you can fall for everyone you see Only one can really make me stay A sign from the sky Said to me You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million You're once in a lifetime You made me discover one of the stars above us I've been looking for that special one And I've been searching for someone to give my love And when I thought that all the hope was gone You smile, there you were and I was gone I always will remember how I felt that day A feeling indescribable to me, Yeah I always knew there was an answer for my prayer And you, you're the one for me You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million You're once in a lifetime You made me discover one of the stars above us I was cool and everything was possible You tried to catch me but it wasn't possible No one could hurt me it was my game Until I met you baby and went insane And when you didn't want me, I wanted you Because the finer thing bout it was I like to go I like it when its difficult I like it when it's hard You know it's worth it if ya find your heart You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million You're once in a lifetime You made me discover one of the stars above us You're one in a million, Oh You're one in a million

Bosson--一在A百万 You现在是一个在百万，哦 You是一个在百万，哦 Sometimes我不可能每天恨您 Sometimes您能为您看的每个人跌倒Only一可能真正地做我逗留从天空的A标志对我的Said You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 I寻找那特别一个我搜寻某人给我的爱的AndAnd，当我认为所有希望是去的 You微笑，那里您是，并且我去 I永远将记住我怎么感觉那天感到的A难以描述对我，呀 I总是知道有我的祷告的一个答复And您，您是那个我的 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 I是凉快的，并且一切是可能的 You设法捉住我，但是它不是可能的没人可能伤害我它是我的比赛 Until我遇见了您婴孩并且去疯狂 And，当您没有想要我，我想要您 Because越美好的事回合它是我喜欢去 I喜欢，当它困难我喜欢时，当它是坚硬时You知道它值得它，如果ya发现您的心脏 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万 You一次在一生 You使我发现其中一个在我们之上的星 You是一个在百万，哦 You是一个在百万

The biomechanical tests showed that two kinds of artificial bones had not significant difference on compressive strength and Young\'s modulus(P＞0.05),while the flexural strength of nano-nacre artificial bone was less than the control group(P＜0.05).3.The results of CCK-8 showed that the difference were not significant in each group,the proliferation of osteoblast reached the peak at the 5th day;7 days after being co-cultured,the total protein content of study group was higher than control group and blank group(P＜0.05),while the difference between control group and blank group was not significantP＞0.05The difference of alkaline phosphatase activities among three groups was not significant(P＞0.05The SEM view showed that osteoblast attached and grew well in two kinds of artificial bone.4.X-ray photography showed that two kinds of powder started to degrade in 2 weeks;this phenomenon became more appear in 4 weeks,nano-nacre powder degraded faster than micron-nacre powder,while the hole shadow was easy to be found;in 8 weeks,all the femoral holes recovered and returned to normal bone mineral density in all groups.Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone grew fastest around the bone defect area in study group,while most slowly in blank groupP＜0.05 SEM(scanning electron microscope observation showed that nano-nacre powder degraded more quickly.The same result can be found through the demineralized sections morphometric analysis,and both of the composite artificial bones made from those two kinds of nacre powder had the good connection with the adjacent tissue in rats body without apparent inflammatory response.5.X-ray photography showed that rabbit\'s bone defects healed faster in study group since NNAB implanted than in control group since MNAB implanted.At 24 weeks after operation,bone density in radial defects had nearly accessed to the normal area,while lower in control group,and turned up nonunion in blank group;The checking of BMD showed that results in study group were higher than those in control group at 8,16 and 24 week(P＜0.05), and the difference between the BMD values in study group at 24 week and those in blank group was not significant(P＞0.05).The gross specimens showed satisfactory histocompatibility both in study group and in control group,with bone tissue growing from two sides into the center of implanted materials; Normal slices in HE stain and hard tissue grinding slices in Stevenel\'s blue/Van Geison\'s picro-fuchsin stain showed that the bone growth tendency was better in study group than that in control group,and the medullary cavity had been penetrated to the implanted materials in study group at 24 week;Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone in both groups grew fastest 8 weeks after surgery,while slow down at 16 week.

纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨分别与成骨细胞共培养后，其各时间点CCK-8法检测值与空白对照无显著差异(P＞0.05)，成骨细胞均在第5天达到增殖高峰期；培养7天后，实验组细胞蛋白含量高于对照组及空白组(P＜0.05)，后两者之间则无显著差异P＞0.05碱性磷酸酶活性在三组间均无显著差异(P＞0.05电镜下可见成骨细胞在两种人工骨上都有良好生长贴附能力。4.X-ray显示两种粉体在大鼠股骨骨洞植入第2周时都开始出现了降解，第4周时更为明显，纳米珍珠层粉较之微米珍珠层粉降解更快，而空白对照组骨洞阴影仍可见，至8周时，则所有组骨洞均己闭合修复，X-ray下已不可见原钻孔痕迹，恢复正常骨质密度；硬组织磨片四环素荧光双标记结果显示纳米珍珠层粉植入组较其余两组在骨缺损区周围新骨生长速度更快，空白组速度最慢P＜0.05电镜观察及常规脱钙切片亦可见到纳米粉体降解较快；由以上两种原材料制得的纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨在大鼠体内均与周围组织结合良好，无明显炎症反应。5.X-ray显示纳米珍珠层/消旋聚乳酸复合人工骨植入兔桡骨缺损区后其骨愈合速度较对照组微米珍珠层/消旋聚乳酸复合人工骨植入的快，至植入术后24周，实验组骨缺损区接近正常骨密度，对照组骨缺损区密度较低，空白组则呈现骨不连状态；骨密度测量结果显示术后8周、16周、24周实验组的骨密度值高于对照组(P＜0.05，24周实验组的骨密度值与术前所测得的正常值无显著性差异P＞0.05动物取材大体所见均显示组织相容性良好，骨组织逐渐由植入材料两端向中央生长；常规切片HE染色及硬组织磨片Stevenel\'s blue/Van Geison\'s picro-fuchsin联合染色均可见实验组骨缺损区长势优于对照组，至术后24周，实验组骨髓腔与材料已呈相交通状；硬组织磨片荧光显微镜下观察，两组材料在术后8周处于骨生长最快速时期，16周时速度开始减慢，术后4、8、16周时实验组的新骨生长速度均较对照组的快

Allah, I ask you for constancy along the way and for resolution in walking the right path and thank you for your goodness and that I worship you in the best sense and I ask of you to give me good from everything you know and keep me from every evil you know and I ask you to forgive all my sins that you know for you are knowledgeable of all things and I ask of you security for me, my family, and all my companions and I seek refuge with you from every despot, from every deceiver and tyrant, from every wizard and every unjust person, from every envier and every traitor, from every conspirator and every enemy, from every one who rants and raves, from every trickster and every gloater and from everyone who conceals enmity from me.

真主啊，我求你一路坚定我的脚步，让我有决心走正路。感谢你的仁慈，我要确确实实的敬拜你，从一切你所知的事中求要好处，求你让我避开你所知的邪恶，宽恕你所知道的我所有的罪，因你是知晓一切的。我求你赐我，我得家人和一切的伙伴安全，向你求庇护，免受一切恶霸，欺诈者，暴虐之人，术士，不义之人，嫉妒者，叛徒，阴谋者，敌人，狂吼乱叫者，**，幸灾乐祸者和暗藏敌意者的伤害。

On it everyone you love, everyone you know, everyone you ever heard of, every human being who ever was, lived out their lives. The aggregate of our joy and suffering, thousands of confident religions, ideologies, and economic doctrines, every hunter and forager, every hero and coward, every creator and destroyer of civilization, every king and peasant, every young couple in love, every mother and father, hopeful child, inventor and explorer, every teacher of morals, every corrupt politician, every "superstar," every "supreme leader," every saint and sinner in the history of our species lived there -- on a mote of dust suspended in a sunbeam....

在地球上，有你所爱的每一个人、有你所知道的每一个人、有你所听说的每一个人，历史上每一个人都在此度过一生；我们所有的欢乐和痛苦、无数坚定的宗教信条、意识形态和经济理论；每一个猎手和强盗、每一个英雄和懦夫、每一个文明的创建者和毁灭者、每一个国王和农夫、每一个相爱的夫妇、每一对父母、每一个满怀希望的孩子、每一个发明者和探险者、每一个有道德的教师、每一个腐败的政客、每一个'超级明星'、每一个'最高领导人'、每一个圣人和罪人，从人类这个种族存在的第一天起——都生活在这颗悬浮在太阳光中的尘埃上。…。

1St Week: A general introduction to the nature and contents of the course; an investigation of students' acquired knowledge of literature in general; a brief introduction to African-American literature 2nd and 3rd Weeks: Rediscovering an Invisible Culture (Why Black culture had been unknown and unobserved for several decades; how it came to be rediscovered ) 4th to 6th Weeks: Double Consciousness (the marginal perspective in Language, Oral Culture, Folklore and Religion); Reading representative works by three Black writers of racial consciousness: Douglass, Washington and Bu Bois 7th to 9th Weeks: Minstrelsy (Imitation, Parody and Travesty in Black-White interaction rituals 1830--1920); Reading the novel about the Black life: Uncle Tom's Cabin 10th to 12th Weeks: Social Mobility and Cultural Stigma: The case of Chicago Jazz 1920--1930; Reading poems by Hughes and novels by Wright 13th to 15th Weeks: Oral Tradition and the Quest for Literacy: The crisis of Black writers from Philips Wheatley to Ralph Ellison; Reading the masterpiece of Ellison 16th to 18th Weeks: Contemporary Afro-American Culture: the sixties and seventies (efforts on reconstructing the Black identiy and Black history); Reading novels by Morrison

第1周：介绍课程性质、内容，了解学生相关文学背景，简要概括黑人文学历史第2-3周：再现黑人文化（黑人文化长期被掩盖的事实和原因，重新被发现的原因和过程）第4-6周：双重意识（语言、吟唱文学、民俗民谣、宗教的边缘化），阅读黑人种族意识三代伟大启蒙家道格拉斯、华盛顿、杜波伊斯的代表作第7-9周：吟游文学（黑人与白人的文化互动过程中的模仿、戏仿、曲仿），阅读第一部反映黑人生活的小说《汤姆叔叔的小屋》第10-12周：社会动荡与文化耻辱（芝加哥爵士乐的兴起、流行和影响），阅读休斯和赖特的代表作第13-15周：口头文学传统与争取教育权利的斗争（从惠特利到埃里森的黑人作家危机），阅读拉尔夫·埃里森的代表作第16-18周：六、七十年代以来的美国黑人文化（重建身份和重建历史的努力），阅读莫里森的代表作每位参加该课程学习的学生均须严格出勤，按时完成学读任务，每学期主持两次小型（10分钟）学术报告，第一次针对老师推荐的作家作品做一个专题报告，第二次针对自己的学期研究计划做一个选题前瞻性和可行性报告。

The aggregate of our joy and suffering, thousands of confident religions, ideologies, and economic doctrines, every hunter and forager, every hero and coward, every creator and destroyer of civilization, every king and peasant, every young couple in love, every mother and father, hopeful child, inventor and explorer, every teacher of morals, every corrupt politician, every "superstar," every "supreme leader," every saint and sinner in the history of our species lived there--on a mote of dust suspended in a sunbeam.

所有我们的欢乐和痛苦，所有言之凿凿的宗教、意识形态和经济思想，所有猎人和强盗，所有英雄和懦夫，所有文明的创造者和毁灭者，所有的皇帝和农夫，所有热恋中的青年情侣，所有的父母、满怀希望的孩子、发明者和探索者，所有精神导师，所有*的政治家，所有"超级明星"，所有"最高领导人"，所有圣徒和罪人，从人类这个种族存在的第一天起——都发生在这颗悬浮在太阳光中的尘埃上。

The aggregate of our joy and suffering, thousands of confident religions, ideologies, and economic doctrines, every hunter and forager, every hero and coward, every creator and destroyer of civilization, every king and peasant, every young couple in love, every mother and father, hopeful child, inventor and explorer, every teacher of morals, every corrupt politician, every "superstar," every "supreme leader," every saint and sinner in the history of our species lived there--on a mote of dust suspended in a sunbeam.1Fpu

所有我们的欢乐和痛苦，所有言之凿凿的宗教、意识形态和经济思想，所有猎人和强盗，所有英雄和懦夫，所有文明的创造者和毁灭者，所有的皇帝和农夫，所有热恋中的青年情侣，所有的父母、满怀希望的孩子、发明者和探索者，所有精神导师，所有腐败的政治家，所有"超级明星"，所有"最高领导人"，所有圣徒和罪人，从人类这个种族存在的第一天起——都发生在这颗悬浮在太阳光中的尘埃上。

The aggregate of our joy and suffering, thousands of confident religions, ideologies, and economic doctrines, every hunter and forager, every hero and coward, every creator and destroyer of civilization, every king and peasant, every young couple in love, every mother and father, hopeful child, inventor and explorer, every teacher of morals, every corrupt politician, every "superstar," every "supreme leader," every saint and sinner in the history of our species lived there – on a mote of dust suspended in a sunbeam.

集合了一切的欢喜与苦难、上千种被确信的宗教、意识形态以及经济学说，所有猎人和抢劫者、英雄和懦夫、各种文化的创造者与毁灭者、皇帝与侍臣、相恋中的年轻爱侣、有前途的儿童、父母、发明家和探险家、教授道德的老师、贪污的政客、大明星、至高无上的领袖、人类历史上的圣人与罪人，通通都住在这里——―一粒悬浮在阳光下的微尘。

The aggregate of our joy and suffering, thousands of confident religions, ideologies, and economic doctrines, every hunter and forager, every hero and coward, every creator and destroyer of civilization, every king and peasant, every young couple in love, every mother and father, hopeful child, inventor and explorer, every teacher of morals, every corrupt politician, every "superstar," every "supreme leader," every saint and sinner in the history of our species lived there — on a mote of dust suspended in a sunbeam.

我们的欢乐与痛苦聚集在一起，数以千计的自以为是的宗教、意识形态和经济学说，每一个猎人与粮秣征收员，每一个英雄与懦夫，每一个文明的缔造和与毁灭者，每一个国王与农夫，每一对年轻的情侣，每一个母亲和父亲；满怀希望的孩子、发明家和探险家，每一个德高望重的教师，每一个腐败的政客，每一个"超级明星"，每一个"最高领袖"，人类历史上的每一个圣人与罪犯，都在这里——一个悬浮于阳光中的尘埃小点上生存。

The Porsche Owner: But it's my car!

可，这是我的车呀。

LOX_83}{Oh, another bunch of wackos.

{LOX_83}{呃，又一群怪人。