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OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.
目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数,优化给药方案,设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式,CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发,在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物,适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上,结合病人个体特征,以1,2个血药浓度作为反馈,即可拟合估算个体药动学参数,优化给药方案结论经初步应用,CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具
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The study shows, the study on Shao-lin Wushu should be based on the combination of "Zen" and "Wu";"respect the tradition, but not blind worship over it " is the main principle in inheriting the tradition, besides, we should maintain an open mind to heritage and development of the Shao-lin Wushu; The innovation should be based on the contemporary virtue, advance with time and combine with our country's development tactics.
本研究认为:少林武术的研究应立足于"禅"与"武"的融合;"尊重传统、不迷信传统"是少林武术的继承原则,并以开放性心态进行少林武术的继承和发展;创新应从文化的当代价值出发,与时俱进,同我国武术发展战略紧密结合。
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Namely: to emancipate our minds, seek truth from facts, opposed to following the beaten track and make progress; theory with practice, and opposed to copy, bookishness; insist on close ties with the masses, against the situation, and bureaucracy; adhere to the principle of democratic centralism and oppose arbitrary, weak and lax; adhere to the Party's discipline, oppose liberalism; insist on honest and clean, and oppose abuse of power; insist on hard work and opposing hedonism; uphold meritocracy and oppose unhealthy trends in the appointment.
即:坚持解放思想、实事求是,反对因循守旧、不思进取;坚持理论联系实际,反对照抄照搬、本本主义;坚持密切联系群众,反对形势主义、官僚主义;坚持民主集中制原则,反对独断专行、软弱涣散;坚持党的纪律,反对自由主义;坚持清正廉洁,反对以权谋私;坚持艰苦奋斗,反对享乐主义;坚持任人唯贤,反对用人上的不正之风。
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Using Latin square test, the effect of geometrical parameters on the characteristics of non-overload sewage pump was studied, and the effecting principle of geometrical parameters on efficiency, maximum brake horsepower and its location were researched, the major and minor factors affecting these performance were found out by way of variance analysis, the correction of equation on maximum brake horsepower and its location were also tested.
用正交试验法研究了各几何参数对无过载排污泵性能的影响,探索了各几何参数对效率、最大轴功率值及其位置的影响规律,并通过方差分析找到了影响这些性能的主要因素和次要因素,验证了无过载排污泵最大轴功率值及其位置公式的正确性,根据试验结果对模型泵提出了进一步设计方案,本试验结果对无过载排污泵水力设计有一定的参考价值。
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Upon the request of the litigants in patent disputes, the municipal intellectual property right bureau strictly followed the principle of "being strict on procedures, being standardized on law enforcement, being fair in results" together with the norm of "People Foremost" in mind, mediated about 14 patent disputes concerning the candleholder patents infringement, etc, in between 4 cases were put on record, 4 cases were closed. It effectively mediated the patent disputes between the litigants, strengthened patentees' independent innovation confidence, defended the fairly competitive market order.
为充分发挥知识产权保护在整顿和规范市场经济秩序中的作用,2006年9月至12月,我市在商贸流通领域开展了为期三个月的知识产权行政执法专项行动,市知识产权局、工商局和版权局共出动知识产权行政执法人员40人次,对全市30余家商贸流通企业开展执法检查,涉及40余万种商品,536种有专利标记的商品,发现97种商品的专利标记不规范,涉嫌冒充专利,市知识产权局及时向各相关单位发出了整改通知,限期进行处理,并现场对商贸企业增强知识产权意识、建立完善知识产权管理制度等进行了宣传辅导。
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In the paper,the prevention and control of adverse impacts on the environment induced by such factors as dust,exhausted air,noise,polluted water and waste mucks are presented,with the emphasis being placed on the expatiation on the protection plan for the air environment inside tunnels and on the principle and methods of the air measurement system.
介绍了铁路隧道施工中对环境造成影响的各项因素,主要针对隧道的粉尘、废气、噪音、污水、废碴的防治进行了全面阐述,并重点阐述了隧道内空气环境的保护方案以及空气检测系统的原理和方案,可供隧道工程及环保工作人员参考。
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To summarize advance on biological signal acquisition and processing system and its application of TCM,on the basis of working principle and its application for example power Lab system,Chinese medical treatment on dystonia,electrophysiology,blood flow,blood pressure and he...
主要以PowerLab系统为例,在阐述生物信号采集处理系统工作原理及应用的基础上,从观察中药对肌张力变换、电生理及血流、血压及血流动力学等的影响等几个方面,综述了生物信号采集处理系统在中医药研究中的应用概况,并提出了应注意的问题。
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Thermal conductivity A of mass and single pellet is successively measured by an efficient and steady heating system, of which the heat source is infrared ray. The milli-volt instrument and thermocouple is a way to measure temperature and its of higher precision and has fewer errors. Thermal diffusivity a is researched based on the study of C and. In this thesis, the volume convective heat-transfer coefficient, is measured on the thin-bed drying plat in terms of the principle of cooling machine and the Boyce drying theory, focusing on the air velocity v or mass flux G affecting on h.
导热系数λ的测定采用红外线纵向热流法,热源稳定、效率高;温度采用毫伏表加热偶温度传感器测量,精度高,误差小,并对成堆物料和单个颗粒均作了研究;基于C和λ的测量结果,导温系数α采用公式法计算而得;对流换热系数h_y为体积对流换热系数,其测定是模拟颗粒饲料的冷却干燥过程,依照冷却器的工作原理,构建颗粒薄层干燥试验台,并在Boyce干燥理论的指导下,重点测试了冷却风速对对流换热系数的影响。
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In accordance with strata combination of composite beams belongs to combination in key delamination on bolt combined effect, on the basis of principle of deformation coordination uniform, calculation formulas were deduced that of bolt pre-tightening force on bolt support in the roof of mining roadway.
在指出锚杆组合作用下组合梁内的岩层组合属于关键分层之间组合的基础上,进一步依据变形协调一致的原则,推导出了回采巷道顶板锚杆支护中锚杆预紧力计算公式。该研究对回采巷道顶板锚杆支护设计具有一定的指导意义和参考价值。
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The thesis combines the objective reality of Shaanxi chemical fertilizer Co., Ltd. of means of agricultural production closely, On the basis of encourage theory survey to the salarying , at first to influence factor that salary assign , staff of enterprise , carry on network analysis thesis, have carried on research to the salary system current situation of staff of chemical fertilizer Co., Ltd. of means of agricultural production of Shaanxi; Have analysed and got the unequal pay for the equal work, the income can"t reflect actual contribution , lack such questions as thereasonable performance appraisal system ,etc.; Regard theory as guidelines, combine the actual conditions of chemical fertilizer Co., Ltd. of means of agricultural production of Shaanxi, the thesis is from the system goal of the salary mainly, setting-up of the principle and tactics, post appraise, post belong to grade , design , salary of scheme respect to structure administrative staff and key post salary system of staff , enterprise of different levels carry on research; Probed into the supplementary measure that company"s salary scheme is implemented finally in thesis.
论文紧密结合陕西农资化肥有限公司的客观实际,在对薪酬和激励理论综述的基础上,首先对影响企业员工薪酬分配的因素进行了系统分析,对陕西农资化肥有限公司员工薪酬体系现状进行了研究;分析了同工不同酬、收入不能体现实际贡献、缺乏合理的绩效考核体系等问题;以理论为指导,结合陕西农资化肥有限公司实际情况,论文主要从薪酬体系目标、原则及策略的建立、岗位评价、岗位归级、薪酬方案的设计等方面对构建企业不同层次的管理人员和关键岗位员工的薪酬体系进行了研究;论文最后探讨了公司薪酬方案实施的配套措施。
- 推荐网络例句
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This one mode pays close attention to network credence foundation of the businessman very much.
这一模式非常关注商人的网络信用基础。
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Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.
扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。
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There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.
双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。