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The dose-dependent experiment revealed that Id1 antagonised E47 and Ets1 mediated transcriptional activation in a dose-dependent manner. With pGL3-870 as a template, site-directed mutagenesis of E-box and / or ETS-binding site was introduced into p16 promoter. E47 could not activate the transcription of p16 promoter with E-boxes mutated, and Ets1 could not activate the transcription of p16 promoter with EBS mutated. The synergy effect between E47 and Ets1 would occur only if the E-boxes and EBS were present. These facts demonstrated that E47 and Ets1 proteins were not recruited to the promoter by binding to other cis-elements or through interaction with other protein factors, however, they bound to DNA directly through respective consensus sequences in p16 promoter.

以pGL3-870为模板，构建了E-box或/和EBS点突变的p16启动子报告基因载体，将野生型和突变型的报告载体分别与pI-E47、pI-Etsl以及pI-E47+pI-Ets1共转染，发现E47和Ets1所诱导的转录激活作用依赖于启动子DNA上存在的各自的特异结合序列，二者的协同作用也只有当两个结合位点都存在时才会发生，说明E47和Ets1不是与其它作用元件或其它蛋白质因子相作用而被招募到该启动子的，它们是通过启动子上各自的特异结合位点与DNA直接结合的。

The result showed that the strong storm followed by mesoscale squall line was primary cause of strong sandstorm producing, steps and ladders short wave trough of 500 hPa was great criterion triggering system for the mesoscale squall line producing, the essential dynamic condition was provided by distortion field and the mesoscale low pressure of 700 hPa for the strong sandstorm forming and maintaining in mid-west of Hexi Corridor, the deep vertical circulation development condition was basic power that urged squall line to occur and sand dust to curl up, which was provided for the deep convection development by superimposition of lifting movement before ground cold front and ascendant current of secondary circulation in upper air jet entrance region, temperature and the barometric gradient around the cold front was enlarged by enhancement of ground thermal low and temperature diurnalvariation of afternoon, by which essential thermal energy unstable condition was provided for the gale and strong sandstorm eruption, the strong sandstorm appeared in downstream of -200 m^2s^(-2) center of vertical helicity, the vertical helicity had good instruction significance for development of squall line and landing region of sandstorm, the mesoscale squall line occurred in unstable stratification, basic condition of potential energy transforming as kinetic energy was provided by strong unstable stratification for the strong sandstorm forming and developing.

结果表明：中尺度飑线所伴随的强风暴是产生强沙尘暴的主要原因；500 hPa阶梯短波槽是中尺度飑线产生的大尺度触发系统，河西走廊中西部700 hp变形场、中尺度低压为强沙尘暴形成和维持提供了必要的动力条件；地面冷锋前上升运动与高空急流入口区次级环流的上升气流的叠加，为深对流发展提供了深厚的垂直环流发展条件，是促使飑线发生和沙尘卷起的基本动力；地面热低压的加强和午后气温的日变化加大了冷锋前后的温度和气压梯度，为大风、强沙尘暴爆发提供了必要的热力不稳定条件；强沙尘暴出现在垂直螺旋度为－200平方公尺/s^2中心的下游，垂直螺旋度对飑线的发展和沙尘暴的落区具有较好的指示意义；中尺度飑线发生在不稳定层结内，较强的不稳定层结为强沙尘暴形成、发展提供了位能转化为动能的基本条件。

The increase in the diffusional deposition was found to occur mainly in the chamber after the vane section when the gas expands and slows down. Therefore, particles have longer residence time to be collected in the chamber by diffusion.

此外发现微粒的扩散损失主要发生於导翼片之后的微粒收集腔体中，因为气流出了导翼片之后速度大幅降低，微粒因而有较长的停留时间由於扩散作用而被收集。

They have to create enough value to cover for the inevitable human infractions that occur in any partnership.

合作需要建立在以诚相待和价值创造的基础上，否则这种关系是无法持久的。

They have to create enough value to cover for the inevitable human infractions that occur in any partnership.

而且，合作也一定要创造尽可能多的价值，来超越人性固有的对不均等的愤恨。

Numerical simulations and analytical results show: in longitudinal and oblique seas, ship may be subjected to primary parametric resonance with large roll amplitude and even capsizing, when encounter frequency is near the twice of roll natural frequency, wave length and ship length are of the same order and the wave height is larger than a certain value; in oblique seas, ship roll motion is a forcedly-parametrically excited oscillation, primary resonance occur as the encounter frequency is near the roll natural frequency, which may lead to large rolling and capsizing too.

数值仿真和解析分析结果表明：在纵浪和斜浪中，当遭遇频率接近船舶横摇固有频率的两倍，波长和船长接近，波高超过某一阈值的时候，船舶会发生主参数共振，产生大幅横摇甚至倾覆；在斜浪中，船舶发生的是参强激励横摇运动，遭遇频率接近横摇固有频率时，还会激起横摇主共振，同样会产生大幅横摇甚至倾覆。

Astrologers at all times and in all land account a harbinger that civilization is about to occur of great change the universe is about to launch a major disaster warning to the planet and humanity.

古今中外的占星家都认为日全食是文明即将发生巨大转变的的预兆，宇宙即将对地球和人类发动大灾难的警告。从历史上看，19 。。。

Person's blood pressure because of these fluctuations occur, mainly due to heart, blood vessels and motor nerve in the blood levels of noradrenaline to regulate blood pressure results, in order to reach a new balance between supply and demand.

人的血压之所以会发生这些波动，主要是由于心脏、血管运动神经及血液中的去甲肾上腺素水平对血压进行调节的结果，从而达到新的供需平衡。

Partitioning problems belong to a kind of NP- complete optimization problems, which occur frequently in the real world. This paper intr oduces a solution to partitioning problems with satisfactory results by using extende d Hopfield neural network.

摘 要 划分问题是一类常见的NP完备的优化问题，本文利用推广的Hopfield神经网络模型解决了划分问题，并取得了较好的效果，为这个问题的解决提供了一条新的途径。

In fact, throughout his entire exposition, the author of the Epistle to the Ephesians is constantly repeating ideas and even particular expressions that occur in the letter to the Colossians, and yet neither a servile imitation nor any one of the well-known offences to which plagiarists are liable, can be proved against him.

事实上，在他整个博览会的作者书信的以弗所是不断重复的想法和具体表现，甚至发生在信歌罗西书，但既不是奴隶，也没有模仿任何一个众所周知的罪行，其中plagiarists者，可以证明对他的。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。