查询词典 notch

Pharmacologic inhibition of the Notch pathway is a potential experimental approach to lung cancer treatment.

通过药物抑制Notch信号途径可能是肺癌治疗的途径之一。

It has recently been shown that the intracellular region of the Notch receptor is proteolytically cleaved by interaction with the ligand and is translocated into the nucleus.

当Notch受体受到配体的刺激而激活时，它的胞内区在蛋白酶作用下从近膜处裂解，释放出胞内区。

This made Notch ligand Delta a potential ideal candidates for the self-renewal and expansion of stem cells. The tentative plan was firstly applied in hematopoietic stem cells, and obtained encouraging results.

最近有人提出利用Notch信号的这种&分化抑制作用&，对干细胞的增殖和分化进行调控的设想，并在造血干细胞研究方面取得了一些令人鼓舞的结果。

"This can be done by using a noel drug to block the Notch pathway while simultaneously controlling estrogen signaling through the estrogen receptor," said Albain, director, thoracic oncology clinical research program; director, breast clinical research program; and co-director, multidisciplinary breast oncology center; Loyola Uniersity Health System, Maywood, Ill.

&这种现象可以通过使用一种新的药物阻断Notch途径同时通过雌激素受体控制雌激素的信号转导来解决，&Albain说，他还是伊利诺州Maywood，Loyola大学健康系统的多学科乳腺肿瘤中心的主任，乳腺临床研究计划的主任，胸部肿瘤临床计划的主任。

The results showed that over 500.0 μg/L of Jagged-1/Fc led to the obvious enhancement of the proportion of CD4+CD25+ T cells within the day 4 to 6 of induction, which was abrogated with an anti-Jagged-1/Fc monoclonal antibody. This induction action of Jagged-1/Fc on CD4+CD25+ T cells was also inhibited by the block of a Notch signal pathway with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester. The level of IL-4 and IL-10 in the supernatant of T cell culture and their intracellular level were elevated by the induction of Jagged-1/Fc,and the level of TGF-β1 in the supernatant was not altered.

结果显示，超过500.0 μg/L剂量的Jagged-1/Fc使CD4+CD25+ T细胞百分比明显增高，诱导时间需要4～6天，抗Jagged-1单抗能抵消Jagged-1/Fc的诱导作用，用DAPT阻断Notch信号通路的活化也能抑制Jagged-1/Fc的诱导作用，Jagged-1/Fc诱导分化的T细胞培养上清中IL-4和IL-10的水平明显增高，TGF-β1无明显变化，胞内IL-4，IL-10，IL-2和TNF-α的水平也呈增高趋势。

In mammals, the Notch signaling pathway is critical for embryonic development, as targeted disruption of Notch1 or its downstream transcription factor RBP-J in mice resulted in disorganization of somites and delayed closure of neurotube, which finally leads to early embryonic lethality.

Notch信号途径在哺乳动物的胚胎发育中起着关键的作用。

Notch is a large, single-pass transmembrane receptor that has been conserved throughout evolution.

Notch受体为细胞表面穿越细胞膜一次的受体蛋白，在演化上被高度的保存。

Hes5 gene, a key downstream mediators of Notch signaling that functions by inhibiting the expression or activity of positively acting bHLH factors, is a member of bHLH transcription factor family which acts as a positive-negative transcriptional regulators which is expressed transiently in different stages in cells growth and differentiation and orchestrate those precisely timed and progressive maturational events underlying cell fate decisions according to orders of time and spatial and coordinated the function of majority of signaling transduction on target genes to influence the proliferation and differentiation.

Hes5是Notch通路转导途径的一个关键的下游信号分子，通过抑制正调控bHLH因子的表达和活性来发挥作用，隶属于碱性螺旋-环区-螺旋转录因子家族。该家族形成一个正负转录调节器，按时空顺序短暂表达于细胞发育分化的不同阶段，介导和协调多种信号系统对大量靶基因的作用，影响细胞增殖、分化。

Together, the data unrael preiously unrecognized expression patterns of Notch signaling-related genes in CD34+ CD38+ cells as they deelop in Jagged1- or Delta1-stromal cell enironments, which appear to reflect sequential maturational stages of CD34+ cells into distinct cell lineages.

以上数据阐明了先前未知的Notch信号相关基因在CD34+、CD38+细胞以及Jagged1-或 Delta1-间充质细胞环境中的表达模式，这会影响CD34+细胞向独特细胞谱系分化的连续成熟期。翻译不当之处请站友不吝赐教！

However, surprisingly little is known about the role of Notch in the development and pathology of Schwann cells and peripheral nerves.

但，关于Notch在雪旺氏细胞和外周神经的发育及病理学中的作用，我们了解的却非常少。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了