查询词典 not in the least

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

"Some research suggests that the positive effects of alcoholic beverages on cardiovascular disorders is not due to alcohol alone but also, at least in part, to other so-called confounding factors such as resveratrol, a compound present in red wine," lead author Steffen Bassus, from the Deutsche Klinik fuer Diagnostik in Wiesbaden, Germany, says in a news release.

该报导作者，同时也是德国Wiesbaden的研究员Steffen Bassus指出，酒精饮料对心血管疾病的帮助并不是凭藉酒精单一成分，另外还需要一些所谓的干扰因素，如红酒中所含的白藜芦醇Resveratrol按此成分在白老鼠身上可降低胆固醇，判断对人体应有相同的效果。

"Some research suggests that the positive effects of alcoholic beverages on cardiovascular disorders is not due to alcohol alone but also, at least in part, to other so-called confounding factors such as resveratrol, a compound present in red wine," lead author Steffen Bassus, from the Deutsche Klinik fuer Diagnostik in Wiesbaden, Germany, says in a news release.

该报导作者，同时也是德国Wiesbaden的研究员Steffen Bassus指出，酒精饮料对心血管疾病的帮助并不是凭借酒精单一成分，另外还需要一些所谓的干扰因素，如红酒中所含的白藜芦醇Resveratrol按此成分在白老鼠身上可降低胆固醇，判断对人体应有相同的效果。

Messina were plenty busy this summer signing players from across the world. Their new additions include players from Italy like Nicolas Cordova, Daniele De Vezze, Massimo Minetti, Antonio Ghomsi, Rok Straus, Edgar Alvarez and Angelo Rea. In addition to French player Lavecchia, Mark Iuliano (who was capped for Italy national football team in Euro 2000 and FIFA World Cup 2002) and last but not least Japanese player Mitsuo Ogasarawa from Kashima Antlers.

梅西纳这个夏天非常忙碌的满世界大肆挖人，他们新签球员包括科尔多瓦、德微泽、米内蒂、贡西、斯特劳斯、阿尔瓦雷斯和雷亚，除此之外还签入了法国球员拉维奇亚、尤里亚诺（参加过2000年欧锦赛和2002年世界杯的意大利国脚）还有从鹿岛鹿角加盟的前日本国脚小笠原满男。

At this point, in spite of some conclusion are direct at a certain industry,not suitable for explain general problems consist in multi- industry , But the conclusion has plenitudinous gists at least and is difficult to be false by approved.

就此而言，尽管有些结论是针对某个产业的，并不适合解释存在于多个产业中的普遍性问题，但这一结论至少是有充分依据而且很难证伪的。

At least half of patients with X-ALD are adults with somewhat milder manifestations, and women who are carriers may become symptomatic. X-ALD is often misdiagnosed as attention-deficit/hyperactivity disorder in boys and as multiple sclerosis in men and women, and is not an uncommon cause of Addison disease;(2) the incidence of X-ALD, estimated to be 1:17 000 in all ethnic groups, approximates that of phenylketonuria;(3) noninvasive and presymptomatic diagnosis and prenatal diagnosis are available; family screening and genetic counseling are key to disease prevention; and (4) new therapies, applied early, show promise.

至少1半的X-ALD为成年病人，表现较轻，而作为携带者的女性也可发病。X-ALD在男孩常误诊为注意缺陷/多动综合征，男女可误诊为多发性硬化，并且也是Addison病的病因；(2)据估计X-ALD发病率为1：17 000，类似于苯丙酮尿症；(3)可进行无创性、症状前诊断和产前诊断；家系筛查和遗传咨询是疾病预防的关键；(4)早期采用新的治疗方法非常具有前景。

At least half of patients with X-ALD are adults with somewhat milder manifestations, and women who are carriers may become symptomatic. X-ALD is often misdiagnosed as attention-deficit/hyperactiity disorder in boys and as multiple sclerosis in men and women, and is not an uncommon cause of Addison disease;(2) the incidence of X-ALD, estimated to be 1:17 000 in all ethnic groups, approximates that of phenylketonuria;(3) noninasie and presymptomatic diagnosis and prenatal diagnosis are aailable; family screening and genetic counseling are key to disease preention; and (4) new therapies, applied early, show promise.

至少1半的X-ALD为成年病人，表现较轻，而作为携带者的女性也可发病。X-ALD在男孩常误诊为注意缺陷/多动综合征，男女可误诊为多发性硬化，并且也是Addison病的病因；(2)据估计X-ALD发病率为1：17 000，类似于苯丙酮尿症；(3)可进行无创性、症状前诊断和产前诊断；家系筛查和遗传咨询是疾病预防的关键；(4)早期采用新的治疗方法非常具有前景。

Teaching contents in this stage include: one is to master scientific piano techniques .in This part, sight-reading, gesture for both hands , the three basic playing methods and the way to practice piano are included; the other is to cultivate students' interests in piano studying, connecting both interests and practice techniques organically ,in this part, teaching material s selection ,various form and contents in class are included ; last but not least to be a popular teacher with students, in this way , the solide basic special skill of teachers own, immidiate respondence to the questions for common knowledge,cordial attitude towards students and to convince them with truth.

然而，在实际的钢琴教学中，存在许多不重视基础训练而盲目拔高演奏程度的现象，从而提出基础教学在钢琴演奏中的重要地位。文章从学生以及老师两个角度进了思考和分析：对于学生来说，首先要认真读谱，其次要掌握钢琴的弹奏技术，再次要在钢琴演奏中有良好的乐感，把音乐弹得赋予表现力和生命力。对于老师来说，首先要培养学生的学习兴趣，使学生能够通过兴趣持久地学习钢琴，其次对待个性不同的学生要因材施教，进行启发式教学，充分发挥学生的主观能动性，最后要为人师表，做一个受学生欢迎的老师。

Teaching contents in this stage include: one is to master scientific piano techniques .in This part, sight-reading, gesture for both hands , the three basic playing methods and the way to practice piano are included; the other is to cultivate students' interests in piano studying, connecting both interests and practice techniques organically ,in this part, teaching material s selection ,various form and contents in class are included ; last but not least to be a popular teacher with students, in this way , the solide basic special skill of teachers own, immidiate respondence to the questions for common knowledge,cordial attitude towards students and to convince them with truth.

然而，在实际的钢琴教学中，存在许多不重视基础训练而盲目拔高演奏程度的现象，从而提出基础教学在钢琴演奏中的重要地位。文章从学生以及老师两个角度进了思考和分析：对于学生来说，首先要认真读谱，其次要掌握钢琴的弹奏技术，再次要在钢琴演奏中有良好的乐感，把音乐弹得赋予表现力和生命力。对于老师来说，首先要培养学生的学习兴趣，使学生能够通过兴趣持久地学习钢琴，其次对待个性不同的学生要因材施教，进行启发式教学，充分发挥学生的主观能动性，最后要为人师表，做1个受学生欢迎的老师。

Finally, this paper points out that description about death is a means of building text clue in text lay. It is also means of manifesting text thought in thought lay. The last but not least, it is also a means of subliming taste lay.

最终明确，在文本层面：死亡描写是文本线索构筑的手段；思想层面：死亡描写是文本思想表现的手段；审美内涵层面：死亡描写是文本达到审美升华的手段。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。