查询词典 not in the least

GSK-3βis now recognized as not only a key rate-limiting enzyme of glycogen metabolic process, which phosphorylats hepatic glycogen synthase and makes it devitalize by insuline regulation, but also plays an important role in at least three signal transductory systems, namely, the Wnt/wingless, PI3'-kinase and Hedgehog pathways,which influence cellular processes, such as protein synthesis, cell proliferation, cell differentiation, cell motility and apoptosis.

GSK-3β是糖原代谢过程中的重要限速酶，除了可以在胰岛素调控下磷酸化肝糖原合成酶并使之失活外，GSK-3β还在多个重要信号通路中扮演了关键角色，例如Wnt/β-catenin pathway，PI3K/AKT pathway，Hedgehog pathway，在蛋白合成、细胞增殖、细胞分化、细胞运动、细胞凋亡以及肿瘤发生等方面都扮演了重要角色。

But I was not content with this Discovery; but having now more Courage, and consequently more Curiosity, I takes my Man Friday with me, giving him the Sword in his Hand, with the Bow and Arrows at his Back, which I found he could use very dextrously, making him carry one Gun for me, and I two for my self, and away we march'd to the Place, where these Creatures had been; for I had a Mind now to get some fuller Intelligence of them: When I came to the Place, my very Blood ran chill in my Veins, and my Heart sunk within me, at the Horror of the Spectacle: indeed it was a dreadful Sight, at least it was so to me; though Friday made nothing of it: The Place was cover'd with humane Bones, the Ground dy'd with their Blood, great Pieces of Flesh left here and there, half eaten, mangl'd and scorch'd; and in short, all the Tokens of the triumphant Feast they had been making there, after a Victory over their Enemies; I saw three Skulls, five Hands, and the Bones of three or four Legs and Feet, and abundance of other Parts of the Bodies; and Friday, by his Signs, made me under stand, that they brought over four Prisoners to feast upon; that three of them were eaten up, and that he, pointing to himself, was the fourth: That there had been a great Battle between them, and their next King, whose Subjects it seems he had been one of; and that they had taken a great Number of Prisoners, all which were carry'd to several Places by those that had taken them in the Fight, in order to feast upon them, as was done here by these Wretches upon those they brought hither.

我做出一想到这种罪恶勾当就要呕吐的样子。然后，我向他招手，叫他马上走开。他立即十分驯服地跟着我走了。我把他带到那小山顶上，看看他的敌人有没有走。我拿出望远镜，一眼就看到了他们昨天聚集的地方。但那些野人和独木舟都不见了。显然他们上船走了，并且把他们的两个同伴丢在岛上，连找都没有找他们。我对这一发现并不感到满足。现在，我勇气倍增，好奇心也随之增大。因此，我带了我的奴隶星期五，准备到那边看个究竟。我给了他一把刀，让他拿在手里，他自己又把弓箭背在背上--我已经了解到，他是一个出色的弓箭手。另外，我还叫他给我背一支枪，而我自己则背了两支枪。这样武装好之后，我们就向那些野人昨天聚集过的地方出发了，因为我很想获得有关那些野人充分的情报。一到那里，呈现在我面前的是一起惨绝人寰的景象，我血管里的血不由得都冰冷了，连心脏也停止了跳动。那真是一幅可怕的景象，至少对我而言实在惨不忍睹，可是对星期五来说，根本不当一回事。那儿遍地都是死人骨头和人肉，鲜血染红了土地；那大片大片的人肉，有的吃了一半，有的砍烂了，有的烧焦了，东一块西一块的，一片狼藉。总之，到处都是他们战胜敌人之后举行人肉宴的痕迹。我看到一共有三个骷髅，五只人手，三四根腿骨和脚骨，还有不少人体的其他部分。

But I was not content with this Discovery; but having now more Courage, and consequently more Curiosity, I takes my Man Friday with me, giving him the Sword in his Hand, with the Bow and Arrows at his Back, which I found he could use very dextrously, making him carry one Gun for me, and I two for my self, and away we march'd to the Place, where these Creatures had been; for I had a Mind now to get some fuller Intelligence of them: When I came to the Place, my very Blood ran chill in my Veins, and my Heart sunk within me, at the Horror of the Spectacle: indeed it was a dreadful Sight, at least it was so to me; though Friday made nothing of it: The Place was cover'd with humane Bones, the Ground dy'd with their Blood, great Pieces of Flesh left here and there, half eaten, mangl'd and scorch'd; and in short, all the Tokens of the triumphant Feast they had been making there, after a Victory over their Enemies; I saw three Skulls, five Hands, and the Bones of three or four Legs and Feet, and abundance of other Parts of the Bodies; and Friday, by his Signs, made me under stand, that they brought over four Prisoners to feast upon; that three of them were eaten up, and that he, pointing to himself, was the fourth: That there had been a great Battle between them, and their next King, whose Subjects it seems he had been one of; and that they had taken a great Number of Prisoners, all which were carry'd to several Places by those that had taken them in the Fight, in order to feast upon them, as was done here by these Wretches upon those they brought hither.

到了洞里，我给他吃了些面包和一串葡萄干，又给了他点水喝。因为我见他跑了半天，已经饥渴不堪了。他吃喝完毕后，我又指了指一个地方，做着手势叫他躺下来睡一觉。那儿铺了一堆干草，上面还有一条毯子，我自己有时也在上面睡觉。于是这个可怜的家伙一倒下去就呼呼睡着了。

These session bitters are not as strong and hoppy as an India Pale Ale would be in the USA although IPAs with modest gravities (below 1040o) have been brewed in Britain since at least the 1920s.

这些普通苦啤酒不像美国的印第安淡色啤酒有浓郁的酒花芳香，尽管在适度比重（1040o以下）便自20世纪20年代在英国酿造。

In the 2-year field experiments, host plant preference and dispersal of the rice water weevil adults of the 1st generation emerged from the 1st cropping season rice were measured on newly transplanted plants of different species and/or growth stage. The weevil preferred significantly to barnyardgrass over Leersia herxandr and Cyperus difformis L with rice at the least, while the age of the plant did not affect such preference. But mean size of feeding scar in on younger plants were larger than in older plants.

在田间自由选择条件下，一代稻水象甲成虫对稗草的选择性显著高于对水稻的选择；稻水象甲对不同生育期的稗草、水稻的选择没有显著影响；对李氏禾和莎草的选择高于水稻，低于稗草；较幼嫩的植物上的取食斑总长度、取食斑平均长度比较老的植物的要长。

The experimental results indicate that the maximum slope angle measured by LSCM reaches at least 50°, and the clear three dimensional profile is obtained in the profile analysis of cantilever. Meanwhile, the deformation accurately measured by two dimensional quantitative analysis is 3.145μm, and the field area is 384μm×288μm in mosaic function equipped with LSCM in 100×objective, which can solve the problem that the watched object's total shape in single frame micrographic image can not be obtained under high microscopic enlargement times.

实验结果表明：运用LSCM测量的斜面最大角度至少可以达到50°；在悬臂梁的形貌分析中，可获得清晰的三维形貌，同时通过二维定量分析精确测得其形变为3.145μm：在100×物镜下，运用拼接功能获得384μm×288μm的视场面积，解决了高放大倍数下，在单帧显微图像中无法获取所观测对象全貌的问题。

The frequency of particular amino acids in signal peptides by statistical approach was 48.54% for hydrophobic, 18.67% for uncharged, 24.54% for negative and 8.00% for positive amino acids. The most frequent amino acid was alanine, and the least was isoleucine. Three classes of signal peptides were found in the genome of P. syringae pv. tomato, 501 ORFs belong to secretary signal peptides, 36 ORFs belong to twin-arginine signal peptides, and 15 ORFs belong to lipoprotein signal peptides. Type IV pilin signal peptide and bacteriocins and pheronones signal peptide was not found in the genome.

同时，对组成信号肽的氨基酸种类作了系统的分析，发现组成信号肽的氨基酸中非极性氨基酸占48.54%，极性氨基酸占18.67%，带负电荷氨基酸占24.54%，带正电荷氨基酸仅占8.00%，出现最多的3种氨基酸依次为亮氨酸、丙氨酸和丝氨酸，最少的氨基酸是异亮氨酸，在切割位点－1端的氨基酸中83.21%均为丙氨酸，在切割位点后3位的氨基酸中最多的氨基酸也是丙氨酸。

As Dr Davies reports in the Public Library of Science ,however, that is not what seems to have happened with at least one piscine antifreeze gene.

不过，正如戴维斯博士在《公共科学图书馆》期刊所报告的那样，进化并不只是发生在至少一种鱼类抗冻基因上。

Western Tibet, which remained to a large extent politically and culturally independent from Central Tibet until the 15th century, preserves an independent– though not homogeneous in itself–tradition of textual transmission, which is–at least partly–represented in the manuscript Kanjurs of Stog, Shelkar and Phudrag.

西藏西部直到十五世纪的时候，在政治和文化上都在很大程度上与藏中保持着相对独立性，保存着独立的佛经传承，这至少部分地在朵、谢噶尔和普扎等地的《甘珠尔》中有所表现。

It is found that zero-displacement mothod can not be used in concrete-filled streel pipe arch bridge. When bend rigidness of tie-bar and bend rigidness of arch is almost same, rigid-support continuous beam mothod and the least-energy mothod without restriction formula is satisfactory.

对于吊杆初始张拉力的确定，将零位移法、刚性支承连续梁法和最小能量法用于南河特大桥吊杆初始张拉力研究，发现零位移法不宜用来确定刚性系杆刚性拱结构的吊杆张拉力，因为该法求解的索力不合理。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。