查询词典 normal matrix

Expression of osteopontin and matrix metalloproteinase-2 were detected in 40 normal placentas ,15 cases with hydatidiform moles by immunohistochemistry technique.

应用免疫组化方法分别检测正常早孕妇女绒毛40例(6周、7周、8周、9-12周各10例)、葡萄胎20例(完全性葡萄胎15例、部分性葡萄胎5例，均12周)组织中骨桥蛋白和MMP-2的表达情况，并采用病理图象分析技术进行半定量分析。

To profile the relativity of osteopontin and matrix metalloproteinase-2 expression in normal placentas and hydatidiform moles.

分析骨桥蛋白和MMP-2在人正常早孕绒毛及葡萄胎中二者的相关性。

This relationship keep the fetus inexclusive from the matrix which is very important to maintain the normal growth of the fetus.

这种关系使作为异物的胎儿不被排斥，对维持胎儿的正常发育有着极其重要的作用。

Results: The renal perfusion was increased in diabetes group after the injection of alloxan. The PSI, AUC and ascending slope rate of the curve of the time-intensity curve were increased in 1w and 2w with decreased of HPT; the pathological examination exhibited glomeruli hypertrophy and no thickening of basal lamina. The PSI and AUC in 4w and 6w were more than that of control group; the PIT and ascending slope rate of the curve got closed to normal in 4w and 6w; the intercapillary cells increased. The speed of ascending slope rate of the curve in 8w, 10w and 12w was slower, shown as PIT and HPT delayed; the pathological examination showned increasing of mesangial cell, hyperplasia of mesangial matrix and thickening of basal lamina, followed with obliteration of partial micrangium, glomerular sclerosis and reduce of PSI in 12w.

结果：糖尿病组兔注射四氧嘧啶后肾皮质血流灌注增大，1周、2周表现为时间-强度曲线参数中峰值强度升高、曲线下面积增大、达峰时间缩短、曲线上升斜率升高，此时病理可见肾小球肥大，系膜基质正常，基底膜无增厚；4周、6周，峰值强度、曲线下面积高于对照组，达峰时间、曲线上升斜率接近正常，系膜细胞增多。8周、10周、12周，达峰时间延长、曲线上升斜率减慢、峰值强度减半时间延长，病理出现肾小球系膜细胞明显增多，系膜基质增生，基底膜增厚，至12周病理出现部分毛细血管管腔闭塞，肾小球节段性硬化，峰值强度测值减低。

This pattern is characterized by the combination of pro-MMP-2 and membrane type 1 (MT1)-MMP expression, which drie pericellular generation of actie MMP-2 and local degradation of normal lier matrix. In addition there is a marked increase in expression of TIMP-1 leading to a more global inhibition of degradation of fibrillar lier collagens by interstitial collagenases (MMP-1/MMP-13). These pathways play a significant role in the progression of lier fibrosis.

其降解肝正常基质，同时抑制引起肝纤维化的纤维胶原降解，这种情况的特点是前明胶酶A合成和膜型1－MMP表达，使得小叶内细胞激活MMP-2和降解当处的正常肝基质，此外血浆1型组织基质金属蛋白酶抑制剂（TIMP-1）明显升高引起广泛的抑制间隙胶原酶(MMP-1/MMP-13)对纤维肝脏胶原的降解。

Objectives:Through the detection of the expression level of interleukins-1β(IL-1β), matrix metalloproteinase 9(MMP-9) and nuclear factor kappa B in Synovium and the detection of the concentration of IL-6 and TNF-αin serum of collagen induced arthritis Wister rat, to investigate the relationship between IL-1β、MMP-9、NF-κB and arthritis index in the development of arthritis,and to understand the pathology of synoviocyte.This may provide an experimented proof for the diagnosis of clinical rheumatical arthritis. Methods: Thirty male Wistar rats were randomly divided into two groups,namely the model controlled group and the normal controlled group,three subgroups were randomly divided in model group and controlled group separately.

目的：通过对白细胞介素1β，基质金属蛋白酶-9，转录因子核因子κB在胶原性关节炎大鼠滑膜细胞表达水平的观察，同时监测同期血清细胞因子IL-6和TNF-α的浓度，旨在探讨白细胞介素1β，基质金属蛋白酶-9，转录因子核因子κB与RA发生发展及其与关节指数之间的相关性，了解炎性病变关节滑膜细胞的病理生理状态，进一步为类风湿关节炎的临床治疗提供实验依据。

Objective: To explore the mechanisms resulting in the recurrence of urethral scar which make urethral strictures difficult to be cured, a series experiments were conducted to find potential effective factors involved in urethral scar formation and degradation, including the studies of extracellular matrix component of urethral stricture scar, the characteristics of urethral scar fibroblast, and the effects of urine on urethral fibroblast in vitro, as well as the studies to compare the difference of collagenase activity, type Ⅰ collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the tissues and cultured fibroblasts from normal urethra and strictured urethra respectively, and the studies to investigate the effect of antisense TIMP-1 oligodeoxyonucleotide on cell proliferation and collagenase activity of urethral scar fibroblast.

中文题名尿道瘢痕基础研究副题名胶原酶活性，TIMP-1的表达及其反义基因治疗外文题名 Experimental study on urethral scar-activity of collagenase，expression of TIMP-1，and antisense TIMP-1 gene transfection of urethral scar fibroblast 论文作者黄翔导师杨宇如教授学科专业外科学研究领域\研究方向学位级别博士学位授予单位四川大学学位授予日期2002 论文页码总数104页关键词尿道手术瘢痕胶原酶成纤维细胞尿道瘢痕馆藏号BSLW /2003 /R699 /12 目的：研究尿道瘢痕的细胞外基质的组成，尿道瘢痕成纤维细胞的生物学特性以及尿液对其生长的影响；比较胶原酶活性，金属蛋白酶组织抑制因子-1（TIMP-1）以及Ⅰ型胶原含量在尿道瘢痕和正常尿道组织及体外培养的成纤维细胞中的差异；研究反义TIMP-1寡核苷酸对尿道瘢痕成纤维细胞增殖以及胶原酶活性的影响。

All these results suppose that COCH gene may play an architectural function in inner ear mesenchymic extracellular matrix, and this architectural stability is critical for the potassium recycling in cochleae and the normal level of endocochlear potential.

COCH基因功能的初步推论，COCH基因可能编码内耳间质组织中一种分泌型糖蛋白，通过与间质组织中其它细胞外基质成分的结合，共同形成稳定的细胞外基质结构框架。

In the normal distraction rate, decalcified bone matrix could promote bone consolidation during distraction osteogenesis compared with blank group.

在正常的牵拉速度下，脱钙骨基质可以促进牵张成骨矿化过程。

Based on the scatted data , a suitable method has been proposed in this paper , in which the least eigenvector of covariance matrix for the local data points is used as the normal vector of the data .

这里针对散乱测量数据点云，以局部数据点协方差矩的最小特征向量作为数据点的方向矢量，并根据实际测量情况，对基于二次曲面拟合的数据点曲率估算算法进行了改进。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。