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The method involves exposing the cells to a compound having the formula I in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a spacer having a chain length equivalent to 1-30 carbon-carbon single covalent bonds or is absent R4 is H or halogen or CH2O-R3; and R1, R2 and R3 are the same or different and are either hydrogen, methyl, ethyl, alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl groups or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl groups optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that at least one of R1, R2 or R3 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated, or to a compound having the formula II in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a space having a chain length equivalent to 1-30 carbon-carbon single covalent bonds or is absent, R5 is alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl group or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl group optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that R5 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated.

该方法包括使细胞暴露于具有式的化合物，在式中：w是核酸，x是非氨基酸或者非肽核酸结合基团，y是具有等于1―30个碳―碳单共价键的链长的间隔基或者不存在，R4是H或者卤素或者CH2O－R3；R1、R2和R3是相同的或者不同的并且是氢、甲基、乙基、烷基、链烯基、羟基化烷基、羟基化链烯基或者包含烷基、链烯基、羟基化烷基或羟基化链烯基的醚，任选地是来源于具有等于3―24个碳原子的碳链长的饱和或不饱和脂肪酸的酰基，其条件是R1、R2或者R3的至少一个包括具有3―24个碳原子的饱和或不饱和碳链的基团，或者使细胞暴露于具有式的化合物，在式中：w是核酸，x是非氨基酸或者非肽核酸结合基团，y是具有等于1―30个碳―碳单共价键的链长的间隔基或者不存在，R5是烷基、链烯基、羟基化烷基、羟基化链烯基或者包含烷基、链烯基、羟基化烷基或羟基化链烯基的醚，任选地是具有等于3―24个碳原子的饱和或不饱和碳链的链长的酰基，其条件是R5包括具有3―24个碳原子的饱和或不饱和碳链的基团。

The design pattern is used to bewrite the decomposite of non-function requires,the relation between non-function requires and SA is set up with structure workflows.The non-function attributes of software architectures are evaluated synthetically based on structure workflows and component combinational operations. According to the evaluation result, a model on software architecture evolution based-on non-function requirements is given.

在软件体系结构描述的基础上，本文使用设计模式描述了非功能需求的分解，使用结构工作链建立了非功能需求与软件体系结构之间的关联，使用结构工作链和组合运算对软件体系结构的非功能属性进行评估，并利用评估结果，提出了一种基于非功能需求的软件体系结构演化方法。

Compared with the initial value problems of scalar conservation laws with smooth flux function, the global weak entropy solutions for the initial-boundary value problems of scalar conservation laws with weak discontinuous flux function include the following new interaction types: a rarefaction wave collides with the boundary and is absorbed compltetely or partially by the boundary; a rarefaction wave collides with the boundary and the boundary will reflect a contact or non-contact shock wave; a contact or non-contact shock wave collides with the boundary and is absorbed by the boundary; a contact or non-contact shock wave collides with the boundary and a new non-contact shock will rebound from the boundary simultaneously or later.

与具有光滑流函数的单个守恒律的初始值问题相比，具有弱间断流函数的单个守恒律初边值问题的整体弱熵解中包括下列新的相互作用类型：稀疏波碰到边界并被边界部分或全部吸收；稀疏波与边界相撞，边界反射出一个接触或非接触激波；接触或非接触激波碰到边界并被边界吸收；接触或非接触激波与边界相撞，边界同时或稍后反射出一个新的非接触激波。

In order to solve the non-tradable share problems of turning non-floating stock into floating stock, it would happen that non-floating stock holders must pay consideration to floating stock holders for gaining circulation rights. From this perspective, the consideration is the core of the non-tradable share reform.

解决股权分置问题，让非流通股股东获得流通权，会在不同程度上损害流通股股东的利益，因此非流通股股东必须为获取流通权向流通股股东支付对价，从这个角度来说，对价是股权分置改革的核心。

objective to investigate the reasons of misdiagnosis on the young patients with non-typical lung cancer,to enhancing the cognition of the disease.methods the data of incidence,clinical manifestation,imageology,bronchoscope,surgical pathologic examination of 32 cases with non-typical lung cancer were analyzed.results 8 cases of 32 patients were misdiagnosed as tuberculosis,7 cases were misdiagnosed as pneumonia,6 cases were misdiagnosed as tuberculosis pleurisy,3 cases were misdiagnosed as omarthritis,2 cases were misdiagnosed as arthritis,2 cases were misdiagnosed as transient ischemic attack,2 cases were misdiagnosed as hemicrania,2 cases were misdiagnosed as intervertebral disk hernia.conclusion the clinical symptom of young patients with non-typical lung cancer was non-typical,and the misdiagnosis rate was high.

目的 探讨不典型青年肺癌误诊的原因，以期提高对本病的认识。方法对32例误诊的青年肺癌(5岁)患者的发病情况、临床表现、影像学检查、支气管镜及手术病理检查进行分析。结果 32例患者中，误诊为肺结核8例，肺炎7例，结核性胸膜炎6例，肩周炎3例，关节炎2例，短暂性脑缺血发作2例，偏头痛2例，椎间盘突出2例。结论青年肺癌临床症状不典型，误诊率较高。

Survey shows that the real estate industry is a major means of tax evasion: individual real estate enterprises to take advantage of off-the-books, accounting, false invoices for the apparent increase of tax evasion; part of the real estate business to avoid tax regulation, does not accurately pre - pay corporate income taxes; own Jian'an inflated costs, the cost ratio does not follow the principle of carry-over, corporate profits as the year in advance the size of carry-over costs, man-made regulation of profits, corporate income tax evasion; together to build the party issuing false invoices, the expansion of another party development costs, the transfer of profits, corporate income tax evasion; advance purchase transactions shall be pegged not to declare their taxable accounts, low-priced sale of product development, drilling policies do not take advantage of value-added tax timely clearing of land; sales garage, storage room through the non-Non-invoiced transfer income, tax evasion related taxes; way to reduce the recording of non-existent staff made售房sales royalty income, personal income tax evasion; with branches or associated enterprises business is not a normal transaction between independent enterprises, and through cross-cutting shared billing or concealed operating items, operating income to conceal tax evasion; bank into the personal housing mortgage loans credited to the "short-term borrowing" subjects, the transfer of income, tax evasion business tax, land value-added tax and enterprise income tax; will develop products for their own use, foreign donations, to cover the debt in exchange for non-monetary assets are not regarded as sales in accordance with the regulations and carry-over income, tax evasion related taxes.

调查显示，房地产业是一个重要的手段逃税：个别房地产企业利用账外账，会计，假发票的情况明显增加逃税；部分房地产业务，以避免税收调节，并没有准确地预先-支付公司所得税；夸大自己的建安成本，费用率并不遵循结转，企业利润为提前一年规模结转成本，人为调节利润，逃避企业所得税；共同建设党的虚开发票，扩大另一方开发成本，转移利润，逃避企业所得税；预购交易应盯住不申报应纳税帐户，低价销售的产品开发，钻政策不利用增值税及时交换土地；销售车库，储藏室通过非非发票转让收入，偷税漏税有关的税收；方式，以减少该记录不存在的工作人员取得售房销售版税收入，逃避个人所得税；与分支机构或关联企业的业务不是一个正常的独立企业之间的交易，并通过交叉共享帐单或隐瞒经营项目，隐瞒经营收入逃税；银行的个人住房按揭贷款记入"短期借款"科目，转移收入，偷税漏税营业税，土地增值税和企业所得税；将开发的产品供自己使用，外国捐款，用于支付债务，以换取非货币性资产不视为销售依照条例和结转收入，偷税漏税有关的税收。房价上涨后，股市下跌

Solid acid catalysts have been found to be useful catalyst in a variety of organic reactions. They have many advantages, such as non-toxic, inodorous, non-volatile; non-corrosive, non-pollution, mild reaction conditions, high yields and reactivity, excellent stability and simple work-up procedure, and these are what liquid catalysts cant replace.

固体酸催化剂在有机合成反应中应用广泛，这类催化剂无毒无味，不挥发，不污染环境，不腐蚀设备，容易回收，可重复使用，所催化的反应条件温和，产率和选择性高，后处理简便，且具有独特的催化性能，这些是液体催化剂所不能代替的。

Using the SEM, polarized light microscope and X-ray analytical method, granule morphology, granulitization and Non-crystalline of starch with non-crystallized granule state were investigated. Corn, tapioca and potato of non-crystalline had blowing out pole. Some poles of non-crystallized corn were big and deep, and the other little and low. Pole of tapioca of non-crystalline was low, and pole of potato was a big, deep stripe.

采用扫描电镜、偏光显微镜、X-射线等分析测试手段，对非晶颗粒态淀粉颗粒形貌以及颗粒性、非晶性进行了研究，发现非晶玉米、木薯、马铃薯淀粉均具有爆裂孔，其中非晶玉米淀粉颗粒的孔有的大而深，有的小而浅；而非晶木薯淀粉颗粒的爆裂孔较浅，而非晶马铃薯淀粉则形成一大而深的长条形的爆裂孔。

The association of microsatellites in rice orphan and non-orphan genes was computed and censused. The result showed: rice has 28532 orphan genes, which accounts for 50.9％, and 27524 non-orphan genes, which accounts for 49. 1％; the microsatellite content in orphan genes is significantly higher than in non-orphan genes; in constitution, tri-nucleotide microsatellite content in ether orphan genes or non-orphan genes exceeds 50％, while the total tri-nucleotide microsatellite content in orphan genes accounts for 68％ and that in non-orphan genes accounts for 58％, of total microsatellites.

对微卫星在水稻孤儿基因与非孤儿基因之间的关系进行了计算和统计分析，结果表明：水稻孤儿基因总数为28532条序列，占50.9％，而非孤儿基因为27524条，占49.1％；孤儿基因中微卫星含量明显高于非孤儿基因；在组成上，不论在孤儿基因还是在非孤儿基因中，三核苷酸微卫星的含量都超过了50％，孤儿基因中的含量为68％，明显高于非孤儿基因的58％。

The numerical model of non-linear wave in harbor, including the non-coupled and non-linear wave numerical model, the numerical model combined Boussinesq equations with Laplace equation and the coupled numerical model combined Boussinesq equations with Euler's equations, are studied.The studies on non-coupled and non-linear wave numerical model are following.

本文分别以Boussinesq方程，二维和三维Laplace方程，欧拉方程和牛顿第二定律作为基本控制方程，分别从非耦合非线性波浪计算模型(指单独采用一个计算模型：本文指Boussinesq方程，或边界元法解Laplace方程，或有限元法解Laplace方程)、Boussinesq方程与Laplace方程耦合计算模型、Boussinesq方程与欧拉方程耦合计算模型三个方面对港口非线性波浪计算模型展开了研究。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！