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LTA-induced delayed PC can prevent brain damage caused by peroxidate reaction and reduce the destruction of ultrastructure of the neuron. The neuroprotective mechanisms of LTA pretreatment may be associated with anti-free radical effect and decreased the cytotoxic effect of NO.

结论LTA诱导的延迟预适应能显著减少大鼠脑组织再灌注损伤,减少脑组织坏死,其作用机制与减少脑I/R后自由基和NO毒性作用有关。

Methods The influence of marine algal polysaccharide on immune function of macrophages inγ-ray irradiat-ed mice was inspected through examining phagocytize activity,IL-1and NO levels of macrophages.

通过测定小鼠腹腔巨噬细胞吞噬功能、产生IL-1和NO能力,考察海藻多糖对γ射线照射小鼠巨噬细胞免疫功能的影响。

Results Phagocytize ac-tivity and the production ability of IL-1and NO in the mice treated with marine algal polysaccharide were increased obvi-ously than that in non-medication group.

结果 海藻多糖处理组小鼠腹腔巨噬细胞吞噬功能、产生IL-1和NO能力较未给药照射组明显增强(P均。05)。

ResultsOnly five species of Pholidota genus were studied and 41 compounds were isolated and characterized including 9,10dihydrophenanthrenes, phenanthraquinone, bibenzyls, stilbenes, triterpenoids, phenyl propanoids, lignans, sterols and aliphatic compounds, and some plants and compounds exhibited analgesic, antioxidant, anticancer and NO production inhibitory activities.

结果目前石仙桃属植物研究所涉及的种类仅5种,从该属植物中分离出化学成分41种,包括9, 10二氢菲、菲醌、联苄、二苯乙烯、三萜、苯丙素、木脂素、甾体和脂肪族等结构类型。一些种类所含成分在镇痛、抗氧化、抗癌、抑制NO生成等方面显示了较好的活性。

The bacterial strain CCTCC No:M208015 provided by the invention is the bacterial strain which is firstly discovered in the phomopsis and can produce gallic acid through fermentation method, the product of the phomopsis bacteria is gallic acid which is the raw material of various medicinal substances.

本发明的菌株CCTCC No:M208015是第一次在拟茎点霉属中发现的能通过发酵法产没食子酸的菌株,其产物为现今多种药物原材料――没食子酸。

After ischemia for 60± 10min the pial microarteries relaxed to maximum and meanwhile the NO increased to maximum too.

缺血(60±10)min时,细动脉扩张至最大值,此时,NO合成也增加至最大值。

Methods The changes of the diameters and the NO on gerbils' pial diameter microvessels were measured by using Laser Doppler and electrical chemistry. The ultrastructure of gerbils'cortex microvessels was observed.

方法采用激光多普勒、电化学和超微病理方法分别测量和观察沙土鼠软脑膜微血管管径、NO含量和脑皮层微血管超微结构的变化。

The changes of plasmatic and hepatic ET-1 and NO were measured at 3rd, 6th, 9th, 12th, 24th hours after endotoxin administration.

观察伤后3,6,9,12,24 h血浆和肝组织ET-1、NO 浓度的变化。

The level of plasmic NO and ET is related to the degree of heart failure.

NO、ET可作为判断风心二狭病情和PBMV疗效及心功能的良好指标。

Both Fas and NO can lead chondrocyte apoptosis respectively and cause articular cartilage destruction. IGF-Ⅰ, TGF-β, bFGF, BMP and other growth factors are polypeptide agents that can influence cell activity by signal convection. They can accelerate chondrocyte proliferation and proteoglycan synthesis, play the local regulation action on formation and plerosis of bone and cartilage tissue by autocrine or paracrine. They have the ability to induce cartilage formation. Some investigations showed that growth factors can influence chondrocyte metabolism, synthesis of specific Ⅱ type collagen and proteoglycan by co-operation and inhibition. 1. 3 Situation of OA therapeutics The therapeutic methods of OA mainly comprised non-drug treatment, drug treatment, operation treatment, tissue and genetic engineering, et al. Drug treatment is the chief method among them.

若其活性发生改变,则将导致关节软骨基质成分的丢失和进行性破坏;软骨细胞凋亡与OA的发病密切相关,Fas与NO可各自独立介导软骨细胞凋亡,造成关节软骨破坏;IGF-Ⅰ、TGF-β、bFGF、BMP等生长因子是一组通过细胞间信号传递影响细胞活动的多肽因子,具有促进细胞生长、增殖与合成等作用,可通过自分泌或旁分泌方式对骨和软骨的形成和修复起局部调节作用,可促进软骨细胞增殖、分化与蛋白多糖的合成,具有较强的诱导软骨形成的能力,研究表明多种生长因子相互促进、相互抑制,以协同或拮抗方式影响软骨细胞代谢,影响软骨细胞特异性Ⅱ型胶原和蛋白多糖的合成分泌。

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