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Abstract] Objective: To explore the inhibitory effect of curcumin on the production of NO and iNOS expression in microglia cell activated by LPS.

目的:观察姜黄素对脂多糖激活的小胶质细胞NO的产生及iNOS表达的影响。

Curcumin could decrease the iNOS expression and suppress the production of NO in activated microglia cells.

姜黄素能够有效抑制脂多糖激活的小胶质细胞iNOS蛋白的表达以及NO的产生。

Investment project of municipal government of Tongliao Trade: construction market Zone and the basic equipment No: 039 Project name Construction of the market of the products flow of coal Cooperation Mode Joint-venture cooperation individual Sum- mary Products Scheme Scale of Operation Forecasting Scales Zhalute County has the abundant resource of coal, the main distribution of the reserve is in Zhahanaoer minery, the reserve of the coal is 9.7 billion tons in the area of Lianhetun Town, Huanghuashan County, Jiurihe County, the soft coal is over 5000 tons, the non smoke coal is over 9000 tons, the annual output is over 280 tons, the competent of the producing will be 17700 thousand tons in 2010, the coal from Huolinguole City and Xilingele League must be carried out through Zhalute County, the Zhalute County is the important coal distribution center in the eastern part of inner Mongolia stepwise.

通辽市人民政府招商引资项目行业:市场、园区及基础设施建设 No:039 项目名称煤炭物流市场建设合作方式合资、合作、独资均可项目概述产品方案经营规模销售预测扎鲁特旗煤炭资源十分丰富,主要分布在扎哈淖尔矿区,联合屯镇、黄花山镇、巨日河镇等地,褐煤储量97亿吨,烟煤储量5000万吨以上,无烟煤量9000万吨以上,现有生产能力年产280吨以上,到2010年生产能力可达1770万吨以上,再加上霍林郭勒市和锡林郭勒盟的煤炭大多通过扎鲁特旗外运,因此扎鲁特镇正逐渐成为内蒙古东部重要的煤炭集散地。

The role of DDAH is to break down modified amino acids Asymmetric dimethylarginine (ADMA and monomethyl arginine that are produced by the body and have been shown to inhibit NO synthase.

DDAH的作用是破坏由体内产生的被修饰的氨基酸(不对称的二甲基精氨酸和一甲基精氨酸)并已证实它可以抑制NO的合成。

As to MNa-ZSM-5, the order is CuNa-ZSM-5〓AgNa-ZSM-5>CeNa-ZSM-5> CoNa-ZSM-5〓FeNa-ZSM-5>Na-ZSM-5. Among the samples tested, CoHZSM-5 shows the highest activity, the conversion of NO is about 60%, and the activity is higher than that of CoNa-ZSM-5 with the same exchanged level. Suggests that the exist of some Bronsted acidity is benefited for this reaction. For Fe-ZSM-5, the activity are changed obviously with the various of preparation condition. It was also found that mordenite zeolite is a good support for this reaction.

其中,Co-HZSM-5表现出最佳的反应活性,NO的最高转化率达60%以上,并且活性明显高于具有相同交换度的CoNa-ZSM-5,表明适量的酸中心存在有利于该反应的进行;对于Fe-ZSM-5,制备条件不同Fe-ZSM-5的反应活性影响很大,反应的活性中心应是处在交换位上的铁离子;另外,通过考察不同载体对铁离子交换分子筛催化剂反应性能的影响,发现丝光分子筛也是较好的催化剂载体。

These two oxadiazole-based multibranched chromophores show the molecular architecture of "D-A-A'-A-D" for BO-G2 and"D'-A-D-A-D'"for NO-G2, which have the different ability of intramolecular charge transfer .

吸收光谱和荧光光谱证实,NO-G2具有较大的激发态和基态偶极矩差值,存在着明显的分子内电荷转移和非线性吸收。

The effect of hesperetin and naringenin on the release of NO in human umbilical vein endothelial cells was investigated next.

采用DAN荧光法测定培养液中亚硝酸盐的含量,间接反映内皮细胞分泌NO的水平。

Hesperetin, but not naringenin can promote the release of NO from HUVEC at relative low level of endogenous estrogen, and this effect is related with regulation of gene expression of eNOS.

其中,只有橙皮素能在雌激素水平不足的情况下促进内皮细胞分泌NO,此效应涉及eNOS的基因表达调节。

Based on the cloning of Spidroin2 cDNA of Nephila clavipes (Genbank Accession No. AF441245), we constructed a prokaryotic expression vector pET-28b-Sp by double digestion.

本研究在获得生长于中国的Nephila clavipes蜘蛛牵引丝蛋白Spidroin2 cDNA(Genbank Accession No。

Although there was no significant difference in the levels of SOD, MDA, and the parameters of the renal function between the L-NAME group and control group,those indexes in the L-NAME group tended to be aggravated. Moreover, the damage in the nephric tissue of the L-NAME group was not alleviated.

给予L-NAME组大鼠与对照组相比,肾组织NO含量明显降低(P.05);两者SOD活性、MDA水平、肾功能指标虽无统计学差异,但有损害加重趋势,肾脏组织损伤未见减轻。

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