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By using 4-chloro-5-nitro phthalimide as raw material and through aminoysis, reduction, cyclization and hydrolysis, end-produce benzimidazole-5,6-diformic acid is prepared.

本发明公开了一种苯并咪唑-5,6-二甲酸的制备方法。该方法是以4-氯-5-硝基邻苯二甲酰亚胺为原料,依次经过氨解、还原、环合、水解反应过程,制得最终产品苯并咪唑-5,6-二甲酸。

Then, N-(5-nitro-6-chloro-3-pyridinemethyl) phthalimide is obtained after the nitrating reaction of N-(6-chloro-3-pyridine methyl) phthalimide. The yield of the obtained product is 90.5%, and its melting point is 143.1~143.8℃.

缩合产物再经过硝化,合成N-(5-硝基-6-氯-3-吡啶甲基)邻苯二甲酰亚胺,其熔点为143.1~143.8℃,收率为90.5%。

A new unsymmetrical metal porphyrin- 5-{4-[3-(2-nitro-phenoxyl) propoxy]phenyl }-10, 15, 20-tri-(4-methoxy phenyl )porphyrin copper (compound Ⅱ)was synthesized,and its UV-Vis spectra were measured and compared with other three symmetrical metalporphyrins.

本文合成了一个新的非对称卟啉铜化合物,测量了其紫外-可见光谱,并将此光谱结果与其他三种对称金属卟啉的光谱进行了比较。

Two colorimetric anions sensors based pyrrolic amide and nitro phenyl have been synthesized in the third part.

在第三部分中,我们设计合成了两种基于吡咯酰胺和硝基苯单元的比色阴离子识别主体。

The preliminary bioassays indicated that, at 500 g/mL, 1-(o-tolyl-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonyl)semicarbazide (4g) and 1-(2,4-dimethyl- phenyl)-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonyl)semicarbazide (4k) showed inhibitory activities 90% and 80% against Blumeria graminis, respectively; and at 25 g/mL, 4-phenyl-4-(4-chloro-3-ethyl-1- methylpyrazol-5-ylcarbonylsemicarbazide (4c) showed inhibitory activity 70.1% against Botrytis cinerea and 1-2-nitro-phenyl-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonylsemicarbazide (4d) showed inhibi-tory activitiy 51.3% against Pyricularia oryzae.

初步生物活性实验结果表明,在500 mg/mL浓度下,化合物1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-(2-甲基苯基)氨基脲(4g), 1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-(2,4-二甲基苯基)氨基脲(4k)对小麦白粉病菌的抑制率分别达到90%和80%;在25 mg/mL浓度下,化合物1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-苯基氨基脲(4c)对黄瓜灰霉病菌的抑制率达到70.1%;化合物1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-苯基氨基脲(4c)和1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-(2-硝基苯基)氨基脲(4d)对稻瘟病菌的抑制率均达到51.3%。

A novel method has been developed for the fluorimetric determination of glucose using tetrasubstituted nitro aluminum phthalocyanine as the fluorescence probe.

建立以四硝基铝酞菁为荧光探针刚定葡萄糖的荧光分析新方法。

In compound 1, Co is in a distorted octahedron environment with four nitro-gen atoms from the tripodal ligand and two oxygen atoms from the bridged oxalate, and the molecule is a dimmer-ic structure consisting of two LCo unites linked by bridging oxalate.

在配合物1中,Co与来自三脚架配体的4个氮和草酸根桥联配体的2个氧原子配位,处于扭曲八面体配位环境。由草酸根桥联两套LCo,构成了一个双核结构。

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后,血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少,Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少,血小板聚集程度及红细胞聚集指数显著上升,病理切片显示胸主动脉内皮细胞破坏明显,脑心肾组织内的血管进一步增厚甚至几乎阻塞,导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR,脑体重比显著升高;心肌内出现明显的缺血梗塞疤痕灶,心体重比显著升高;肾小球明显萎缩、玻璃样变性,肾小管也变性甚至坏死,使肾硬化程度显著增加呈颗粒性固缩肾,肾体重比也显著减少。

Provided unassembled with clear, concise instructions, the Nitro RS4 3 18SS + is a joy to assemble and run!

提供unassembled与清晰,简明的指示,硝基rs4 3 18ss +是一种喜悦,组装和运行!

Objective To study the effect of nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester on extinction of cued fear.

目的 探讨一氧化氮合酶抑制剂N-硝基-L-精氨酸甲酯对大鼠线索性恐惧消退的影响。

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I can not make it blossom and suits me

我不能让树为我开花

When temperatures are above approximately 80 °C discolouration of the raceways or rolling elements is a frequent feature.

当温度高于 80 °C 左右时,滚道或滚动元件褪色是很常见的特征。

The lawyer's case blew up because he had no proof.

律师的辩护失败,因为他没有证据。