查询词典 neurotrophic

AIM: To observe the changes of tyrosine hydroxylase protein levels and the density of dopaminergic amacrine cells before and after the administering brain derived neurotrophic factor protein into the vitreous cavities of streptozotocin reduced Wistar diabetic rats.

目的：观察玻璃体腔内注射脑源性神经营养因子（Brain derived neurotrophic factor，BDNF）前后STZ糖尿病大鼠视网膜中酪氨酸羟化酶（tyrosine hydroxylase，TH）的水平及多巴胺能无长突细胞数目的变化。

Objective To establish human brain-derived neurotrophic factor genetical modified marrow stromal cells and to evaluate the influence on the viability of the cultured spiral ganglion cells from Kunming mice.

目的 探讨人脑源性神经营养因子(brain-derived neurotrophic factor， BDNF)基因工程细胞的建立及其对体外培养的小鼠螺旋神经元生长活性的影响。

The former, intracranially complements patients some factors, most frequently with TH gene to compensate scanty of intrastriatal DA and improve the symptoms of the patients, while have little resistance to the progressive degeneration of dopaminergic neurons; The latter provide variety of neurotrophic factors, most specific being the glial cell-line derived neurotrophic factor , to protect the residual DA neurons in the nigrostriatal system from further pathogenic injuries, while have little benefit to those DA neurons with irreversible damage, and them cannot offset the already-existing symptoms.

前者是给宿主脑内补充某些因子，主要是DA合成过程中的限速酶TH基因，以补充纹状体内DA含量的不足，减轻患者的症状，但对DA能神经元的进行性退变没有治疗效果；后者则是提供各种神经营养因子其中最具特异性的为GDNF，以保护黑质一纹状体系统内剩余的DA能经元免受病因的继续损害但对已发生不可逆性损害的DA能神经元并无拯救作用，无法消除已出现的症状。

Brain-derived neurotrophic factor is the most abundant neurotrophin in many parts of brain, such as pallium, hippocampus and so on.

脑源性神经营养因子(brain-derived neurotrophic factor，BDNF)作为脑组织中含量最丰富的神经营养因子，在中枢神经系统内合成并广泛存在于脑组织，包括大脑皮层、海马、基底前脑、纹状体、下丘脑和小脑，其中以海马和皮层中含量最高。

Objective To study the levels of brain-derived neurotrophic factor protein in experimental dogs using multiple cauda equina constrictions throughout the entire lumbar, sacral and coccygeal spinal cord and their central processes of the dorsal root ganglia neurons resulting in the acute and severe cauda equina syndrome.

目的研究实验性犬急性重度马尾神经压迫48h的相关脊髓和背根神经节（dorsal root ganglion，DRG）内脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）蛋白表达水平。

Research of microenvironment werefocused on the neurotrophic factors. Many studies have been done to use nerve conduits filled with exogenetic NTFs with the intention of promote axonal regeneration to the greatest extent efficiently. However concentration of exogenetic NTFs and the means of releasing NTFs still need to be studied.

对于后者，研究主要集中在神经营养因子(neurotrophic factors，NTFs)，众多学者尝试将外源性NTFs引入神经导管，以期尽可能有效地促进轴突再生，但外源性NTFs导入的浓度和释放的途径仍需进一步研究，同时最有益于神经再生所必须的营养因子的数量和种类也待进一步明确。

Many studies reported suggest both neuronal precursor cells before innervation of target fields and the neurons of adult animal coexpress neurotrophic factors and their receptors, implying that autocrine and paracrine modes of NTFs exit. It has been observed that a number of neurotrophic factors and their receptors were expressed in cultured hippocampal cells and dorsal root ganglionic cells.

研究表明，无论是靶组织联系建立以前的神经元前体细胞，还是成年后的神经元，均有神经营养因子与其受体的共同表达，提示有神经营养因子自分泌和旁分泌存在的可能性。

The experimental study is to explore the effect about rhEPO on neuromotor function, secondary pathology change and expression of NTF and the apoptosis of neural cell, which administered at different time after traumatic spinal cord injury. The experimental study is devided into three parts: The first part The effect of rhEPO on NT-3 and NGF expression after traumatic spinalcord injury Objective Nerve growth factor and neurotrophic factor–3(NT-3) are chief members in neurotrophic factors family, which can promote nerve cell survival、growth and differentiation.

本研究拟在脊髓损伤后不同时间应用促红细胞生成素干预，探讨其对神经运动功能和继发性病理改变的保护作用及对神经营养因子表达和神经细胞凋亡的影响，共分为以下三个部分：第一部分脊髓损伤后促红细胞生成素对NGF、NT-3表达的影响目的：神经生长因子和神经营养因子-3(NT-3)是神经营养因子家族的主要成员，是机体产生的能够促进神经细胞存活、生长、分化的一类多肽或蛋白质因子。

It is proved that MSCs in vitro secret brain - derived neurotrophic factor , and other neurotrophic factors continuously.

因此，有必要弄清移植到脑内的MSCs是否通过产生BDNF等神经营养因子，从而发挥对缺血神经元的保护作用。

Following the deep researches of glaucoma pathological mechanism, the protective effects of neurotrophic were more and more important for therapy of glaucoma.ciliary neurotrophic factor can induce differentiation of nerve cells, decrease apoptosis of nerve cells and accelerator regeneration of cells.

随着对青光眼病理机制研究的深入，其治疗也由单一的降低眼内压的同时加强神经功能的保护，睫状神经营养因子可诱导多种神经细胞分化，减少神经细胞凋亡和促进细胞再生。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。