查询词典 neurotoxic

The existing nonclinical data implicate not only NMDA-receptor antagonists, but also drugs that potentiate -aminobutyric acid signal transduction, as potentially neurotoxic to the developing brain.

现有的非临数据提示不仅 NMDA 受体拮剂还有其他强γ-氨基酸信号转换的药物对发育的大脑有潜在的神经毒性。

The potential for the combination of drugs that have activity at both receptor systems or that can induce more or less neurotoxicity is not clear; however, recent nonclinical data suggest that some combinations may be more neurotoxic than the individual components.

联合用药的潜在风险激活受体系统或强减轻神经毒性还未知。然而现有的非临数据显示一些联合用药的毒性大于任何的单独应用。

IDO inhibits the proliferation of eukaryotic intracellular pathogens or tumor cells by depriving them of tryptophan. IDO has been targeted for neurological disorders: it causes decrease of serotonin level in the brain resulting depression, and it causes the accumulation of neurotoxic quinolinic acid. IDO plays a key role in the suppression of T cell response and antitumor immune, it induces immune tolerance to embryo and explant.

IDO可通过降低微环境中色氨酸的浓度而达到抑制病原微生物增殖的作用； IDO与神经系统疾病也密切相关，它能降低5-羟色胺的水平而导致抑郁，也可造成脑中喹啉酸等具有神经毒性的代谢产物的累积； IDO在抑制T细胞免疫和抗肿瘤免疫、诱导母胎免疫耐受和移植物免疫耐受中均发挥重要的代谢性免疫调节作用。

Changes of the NOS activity and the expression of NOS protein in central nervous systems of rats,which were subacutely intoxicated with oral exposure to lead acetate for 30 days,were observed with improved NADPH techniques and immunohistochemistry to study neurotoxic mechanism of lead.

本文采用SD成年大白鼠饮用醋酸铅水染毒30天，然后用改进的NADPH测定法及免疫组化SP法观察脑组织中NOS酶活性及NOS酶蛋白亚型的变化。

The machanism may be that 7-NI inhibits activation of nNOS and decreases the number of overproducing neuronal NO in hippocampal during anoxia,so the ability of hippicampal slices against anoxic injury is increased and neurotoxic role of neuronal NO during anoxia is definite.

作用机理可能是7-NI抑制nNOS活性降低缺氧后海马神经原性NO的过多形成，从而提高海马脑片抗缺氧损伤的能力，更加明确了缺氧早期神经原性NO的神经毒性作用。

"Dental amalgams contain mercury, which may have neurotoxic effects on the nervous systems of developing children and fetuses," reads a statement that has been added to the agency's Web site.

&银汞合金含有汞，对于成长中的儿童和胎儿的神经系统具有神经毒性作用，&这一段陈述已被加入到该机构的网站中。

"Dental amalgams contain mercury,which may have neurotoxic effects on the nervous systems of developing children and fetuses,"reads astatement that has been added to the agency\'s Web site.

&银汞合金含有汞，对于成长中的儿童和胎儿的神经系统具有神经毒性作用，&这一段陈述已被加入到该机构的网站中

If these findings are confirmed,"iron chelators or free radical trapping agents should be used to reduce the neurotoxic effects of iron in patients with acute ischemic stroke who are treated with intraenous t-PA," the team concludes.

&如果这些发现被证实了，那么在对急性缺血性脑卒中的患者给予静脉t-PA治疗时，应该同时使用铁螯合剂或是自由基捕获剂，从而来减少铁所造成的神经毒性作用&，研究小组这样总结道。

To test whether ethylene oxide retained in the dialyzers might be neurotoxic, tissue culture medium was incubated in the blood compartment of dialyzers.

如果组织培养基在透析器内孵育，然后将鼠的背根神经节（DRG培养物暴露于此培养基中，则DRG的特异性变化会发生。

In order to study the neurotoxic effects of xylene on the nervous system in rats,the concentrations of amino acid neurotransmitter and enkephalin were analyzed using HPLC and RIA.

目的 探讨二甲苯对大鼠神经系统的影响。方法应用高效液相色谱法和放射免疫测定法，分别对大鼠脑组织中氨基酸类递质和脑啡肽含量进行了分析。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。